Antitumor activity of low-dimensional alumina structures

Abstract

Abstract. Nano-dimensional materials have recently attracted much attention with respect to their potential role in medicine. Physical mechanisms of interaction of nanoparticles with tumor cells will help to develop new methods for cancer disease treatment. Based on aluminum oxide phases, positively charged low-dimensional structures have different shape: agglomerates of nanosheets, nameplates, cone-shaped nanoaggregates were synthesized with the help of aluminum nanoparticles. The cytotoxicity effect of these low-dimensional structures on A549, HeLa, MDA, PyMT tumor cells was studied. It was shown that agglomerates of nanosheets were more toxic for investigating cell lines. Agglomerates of nanosheets had a medium toxic effect at a concentration of 10 mg/ml while nameplates and cone-shaped nanoaggregates were nontoxic. The toxic effect of agglomerates of nanosheets correlates with their shape, mainly the presence of multiple edges.

Antibacterial Calcium Phosphate Coatings with Zinc Oxide Nanoparticles

“…The nanoparticles' shape and structure contribute to reducing the attraction forces between particles. As shown in [24,35], AlO(OH) nanoparticles after hydrolysis are characterized by a complex structure with needle branches, which leads to a high binding energy between nanoparticles and high fractions of particles with larger sizes. In contrast, the ZnO nanoparticles have geometric shapes (hexagon, circle, square, rectangle) (Figure 2a), which can reduce particle agglomeration.…”

Two-dimensional Al hydroxide interaction with cancerous cell membrane building units: Complexed free energy and orientation analysis

“…Recently it has been experimentally found that the low-dimensional aluminum oxyhydroxide is prospective nanomaterial (AlOOH-NM), at least, to be adjuvant in anticancer therapy [9,10]. The mechanism of AlOOH-NM antitumor activity may be provided by the oxyhydroxide influence on pH of extracellular media [11,12] or/and by probable violations in the cell membrane structure accompanied by membrane protein dysfunction, as well as by facilitating cellular uptake of the therapeutic agents, or something fourth.…”