Assessment of the Activity of a Novel Light-Activated Antimicrobial Coating in a Clinical Environment

Abstract

Cellulose acetate coatings containing the light-activated antimicrobial agents toluidine blue O and rose bengal have previously been shown to be successful in killing a range of microorganisms. Here, we report on the ability of these coatings to achieve reductions in the microbial load on surfaces in a clinical environment.

Biomedical Applications of Photo- and Sono-Activated Rose Bengal: A Review

“…2,42 As discussed by Spagnul et al, 3 RB for antimicrobial PDT can be incorporated into natural polymers, such as in chitosan nanoparticles or on to cellulose acetate surfaces. Manoil et al 43 discussed the use of RB-Acetate against Enterococcus faecalis, resulting in reduced bacterial viability, whereas Decraene et al 44 demonstrated reduced environmental contamination on clinical surfaces by using cellulose RB-Acetate coatings. RB can also be linked to synthetic polymers, such as silica, polystyrene, and polyethylene supports.…”

Effectiveness of an Antimicrobial Polymer to Decrease Contamination of Environmental Surfaces in the Clinical Setting

“…D'Antionio et al ., coated hospital keyboards with an antimicrobial polymer (Biosafe HM 4100) embedded into polyurethane, also in a simulated setting, and observed reduced viability of MRSA, VRE, E. coli and P. aeruginosa (6). The use of light-activated (photosensitizer) antimicrobial agents to reduce bacterial contamination of surfaces has also been studied and demonstrated significantly reduced contamination of objects on a shelving unit in a clinical setting(7-9). These studies suggest that antimicrobial coating of healthcare surfaces is a potential useful strategy in infection prevention efforts aimed at reducing transmission of microorganisms from the environment to patients.…”

Eosin-mediated synthesis of polymer coatings combining photodynamic inactivation and antimicrobial properties

“…31 The same procedure has been used to develop novel light activated antimicrobial coatings from the evaporation of acetone solutions of Toluidine blue O and Rose Bengal incorporated in cellulose acetate. 32,33 A second interesting approach 34 consisted of linking hydroxyl groups of polyol-derived porphyrins and isocyanate to polyurethane (PU) via a thermal polymerization. The resulting formulation has been sprayed via an air brush system onto polymethylmethacrylate substrates to form a 30 mm PU-coating thickness.…”