Effectiveness of an Antimicrobial Polymer to Decrease Contamination of Environmental Surfaces in the Clinical Setting

Thom, Kerri A.; Standiford, Harold C.; Johnson, J. Kristie; Hanna, Nader; Furuno, Jon P.

doi:10.1086/677159

Cited by 6 publications

(3 citation statements)

References 9 publications

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“…The anionic dye, purple in aqueous solution, turns blue when it forms an ion pair complex with a quaternary -onium functionality. 109 As a result, it is an effective qualitative method for quick visualization of phosphoniums tethered to a substrate: the colourless substrate is stained blue upon complexation with the BPB dye (Figure 1.14). 17 In 2007, Murata and coworkers utilized a different anionic dye, fluorescein, to quantify accessible surface charge.…”

Section: Detection Of Phosphonium On Surfacesmentioning

confidence: 99%

Phosphonium Containing UV-Curable Antimicrobials for the Coating and Fabrication of Common Touch Plastics

Bedard¹

2022

Preprint

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<p>The attachment and proliferation of antibiotic resistant, biofilm-forming bacteria to oft- handled material surfaces has emerged as a growing concern, particularly in the biomedical, healthcare and food packaging industries. The development of both biocide-releasing and tethered, immobilized biocide surface coatings has risen to meet this demand. While these surface coatings have demonstrated excellent antimicrobial efficacy, there are few examples of antimicrobial surfaces with long-term durability and efficacy. To that end, UV-curable phosphoniums bearing benzophenone anchors were synthesized with a variety of alkyl, aryl, and fluoroalkyl functional groups at phosphorus to probe their efficacy as thermally stable antimicrobial additives in plastics or as surface coatings. The surface topology and characteristics of these materials were studied to gain insight into the mechanism of antimicrobial activity of these materials. Additionally, general design principals for tailoring phosphoniums to function as both additives during injection molding processes and as UV-curable coatings are described, and evaluation against both Gram-negative and Gram-positive bacteria in both applications were carried out. Crucially, polypropylene (PP) materials containing phosphonium with a perfluoroalkyl substituent maintained the ability to kill biofilm-forming bacteria even after being subject to abrasion processes, demonstrating the potential to serve as a long-term antimicrobial material.</p>

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Section: Detection Of Phosphonium On Surfacesmentioning

confidence: 99%

Phosphonium Containing UV-Curable Antimicrobials for the Coating and Fabrication of Common Touch Plastics

Bedard¹

2022

Preprint

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“…Sodium hypochlorite disinfection, which comprised any disinfection method specified as bleach or sodium hypochlorite, was identified in 19% of studies [20,44,60 For surface interventions, we found that copper surfaces were in 9% of studies [90,132,152,154,[167][168][169][170][171][172][173][174][175][176][177][178][179]. Other non-copper surface applications or coatings comprised 8% of studies [87,102,[180][181][182][183][184][185][186][187][188][189][190][191][192]. Other non-copper surfaces included coatings incorporating metals such as titanium oxide and silver ions as well as other coatings comprised of polymers, isopropyl alcohol and organofunctional silane, organosilane products, silicon nano-coating inorganic metal and organic quaternary ammonium, silicone quaternary amine, quaternary ammonium silyl oxide, and titanyl oxide moieties.…”

Section: Disinfection Typementioning

confidence: 99%

Evidence Map and Systematic Review of Disinfection Efficacy on Environmental Surfaces in Healthcare Facilities

Christenson¹,

Cronk

Atkinson³

et al. 2021

IJERPH

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Healthcare-associated infections (HAIs) contribute to patient morbidity and mortality with an estimated 1.7 million infections and 99,000 deaths costing USD $28–34 billion annually in the United States alone. There is little understanding as to if current environmental surface disinfection practices reduce pathogen load, and subsequently HAIs, in critical care settings. This evidence map includes a systematic review on the efficacy of disinfecting environmental surfaces in healthcare facilities. We screened 17,064 abstracts, 635 full texts, and included 181 articles for data extraction and study quality assessment. We reviewed ten disinfectant types and compared disinfectants with respect to study design, outcome organism, and fourteen indictors of study quality. We found important areas for improvement and gaps in the research related to study design, implementation, and analysis. Implementation of disinfection, a determinant of disinfection outcomes, was not measured in most studies and few studies assessed fungi or viruses. Assessing and comparing disinfection efficacy was impeded by study heterogeneity; however, we catalogued the outcomes and results for each disinfection type. We concluded that guidelines for disinfectant use are primarily based on laboratory data rather than a systematic review of in situ disinfection efficacy. It is critically important for practitioners and researchers to consider system-level efficacy and not just the efficacy of the disinfectant.

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“…Treated surfaces are exposed to a solution of BPB and the surface will visually stain blue to indicate the presence of the compound. 53,54 This technique can confirm the presence of the antimicrobial compound prior to biological testing. Scheme 1.5 Coating visualization by BPB staining.…”

Section: Coating Visualizationmentioning

confidence: 99%

Robust UV-Curable Antimicrobial Polymeric Coatings for Medical Plastics Prepared by Controlled Radical Polymerization

Shum¹

2021

Preprint

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In response to hospital acquired infections stemming from biofilms and the impending antibiotic resistance crisis, the development of non-traditional, non-leachable antimicrobials have gained significant traction. Contact-active antimicrobial coatings physically attached to surfaces with cationic active sites, such as ammonium and phosphonium, are of particular interest in the prevention of pathogenic bacterial transfer. Previously reported antimicrobial coatings are found to be susceptible to abrasion, significantly limiting their potential applications. In this work, a range of robust, antimicrobial polymeric coatings synthesized by control radical polymerization are presented. Polymeric thin film coatings possessing cationic groups with n-alkyl substituents of n ≤ 4 demonstrated antimicrobial properties against gram-positive bacteria, while species containing bulkier substituents were biologically inactive, contradictory of previously reported monomeric coatings. Cationic polymeric brush coatings were found to have a higher antibacterial activity against the gram-positive model compared to its non-brush equivalent, but failed against the gram-negative model. These polymeric thin films demonstrate the complexity of antimicrobial coating designs and facilitates the investigation into the architecture of these coatings.

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Effectiveness of an Antimicrobial Polymer to Decrease Contamination of Environmental Surfaces in the Clinical Setting

Cited by 6 publications

References 9 publications

Phosphonium Containing UV-Curable Antimicrobials for the Coating and Fabrication of Common Touch Plastics

Phosphonium Containing UV-Curable Antimicrobials for the Coating and Fabrication of Common Touch Plastics

Evidence Map and Systematic Review of Disinfection Efficacy on Environmental Surfaces in Healthcare Facilities

Robust UV-Curable Antimicrobial Polymeric Coatings for Medical Plastics Prepared by Controlled Radical Polymerization

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