Assessment of Synthesis Machinery of Two Antimicrobial Peptides from Paenibacillus alvei NP75

Jagadeesan, Yogeswaran; Selvamanikandan, Athinarayanan; Ayub, Sabeena Begum Mohamed; Balaiah, Anandaraj

doi:10.1007/s12602-019-09541-w

Cited by 5 publications

(2 citation statements)

References 42 publications

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“…Antibiogram assay was performed by modifying the agar disc diffusion assay described by Jagadeesan et al 36 The strain P. aeruginosa AR01 was swabbed on sterile Mueller-Hinton agar plates. Commercial antibiotic discs, each 30 mg (neomycin, erythromycin, colistin, chloramphenicol, ciprooxacin, bacitracin, tetracycline, ampicillin, penicillin, streptomycin and vancomycin), were then placed on the agar surface.…”

Section: Antibiogram Assaymentioning

confidence: 99%

Combinatorial approach for screening and assessment of multiple therapeutic enzymes from marine isolatePseudomonas aeruginosaAR01

Jagadeesan¹,

Meenakshisundaram²,

Boopathy

et al. 2019

RSC Adv.

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Section: Antibiogram Assaymentioning

confidence: 99%

Combinatorial approach for screening and assessment of multiple therapeutic enzymes from marine isolatePseudomonas aeruginosaAR01

Jagadeesan¹,

Meenakshisundaram²,

Boopathy

et al. 2019

RSC Adv.

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“…Two different antimicrobial peptides characterized as Paenibacillin N and P with potent 222 antimicrobial activity against many clinical pathogens were produced by P. alvei NP75[29].223Interestingly, compounds were differentially synthesized -Paenibacillin N was non-ribosomally 224 synthesized whereas Paenibacillin P was synthesized ribosomally. Moreover, the aforementioned 225 strain produced an extracellular protease defending itself from Paenibacillin P.…”

mentioning

confidence: 99%

Paenibacillus alvei MP1 as a Producer of the Proteinaceous Compound with Activity against Important Human Pathogens, Including Staphylococcus aureus and Listeria monocytogenes

et al. 2020

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An emerging need for new classes of antibiotics is, on the one hand, evident as antimicrobial resistance continues to rise. On the other hand, the awareness of the pros and cons of chemically synthesized compounds’ extensive use leads to a search for new metabolites in already known reservoirs. Previous research showed that Paenibacillus strain (P. alvei MP1) recovered from a buckwheat honey sample presented a wide spectrum of antimicrobial activity against both Gram-positive and Gram-negative pathogens. Recent investigation has confirmed that P. alvei MP1 (deposited at DDBJ/ENA/GenBank under the accession WSQB00000000) produces a proteinaceous, heat-stable compound(s) with the maximum antimicrobial production obtained after 18 h of P. alvei MP1 growth in LB medium at 37 °C with continuous shaking at 200 RPM. The highest activity was found in the 40% ammonium sulfate precipitate, with high activity also remaining in the 50% and 60% ammonium sulfate precipitates. Moderate to high antimicrobial activity that is insensitive to proteases or heat treatment, was confirmed against pathogenic bacteria that included L. monocytogenes FSL – X1-0001 (strain 10403S), S. aureus L1 – 0030 and E. coli O157: H7. Further studies, including de novo sequencing of peptides by mass spectrometry, are in progress.

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Greener and Sustainable Biovalorization of Poultry Waste into Peptone via Bacto-Enzymatic Digestion: A Breakthrough Chemical-Free Bioeconomy Waste Management Approach

Jagadeesan

Meenakshisundaram

Saravanan

et al. 2022

Waste Biomass Valor

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Assessment of Synthesis Machinery of Two Antimicrobial Peptides from Paenibacillus alvei NP75

Cited by 5 publications

References 42 publications

Combinatorial approach for screening and assessment of multiple therapeutic enzymes from marine isolatePseudomonas aeruginosaAR01

Combinatorial approach for screening and assessment of multiple therapeutic enzymes from marine isolatePseudomonas aeruginosaAR01

Paenibacillus alvei MP1 as a Producer of the Proteinaceous Compound with Activity against Important Human Pathogens, Including Staphylococcus aureus and Listeria monocytogenes

Greener and Sustainable Biovalorization of Poultry Waste into Peptone via Bacto-Enzymatic Digestion: A Breakthrough Chemical-Free Bioeconomy Waste Management Approach

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