Assessment of subclinical atherosclerosis in hidradenitis suppurativa

Pascual, José C.; González, Iris; Corona, D.; Hispán, Patricia; Ramos, José Manuel; Sánchez‐Paya, José; Jemec, Gregor B. E.

doi:10.1111/jdv.14076

Cited by 29 publications

(25 citation statements)

References 30 publications

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“…In a recently population‐based cohort study, HS was associated with a significantly increased risk of major adverse CV events, including myocardial infarction, ischaemic stroke and CV‐associated death . In keeping with these findings, we and others have recently demonstrated an increased prevalence of subclinical atherosclerosis in HS patients . Furthermore, HS has also been associated with a greater prevalence of CV risk factors, such as diabetes mellitus (DM), dyslipidaemia, cigarette smoking, metabolic syndrome (MS) and obesity .…”

Section: Introductionsupporting

confidence: 78%

“…Furthermore, HS has also been associated with a greater prevalence of CV risk factors, such as diabetes mellitus (DM), dyslipidaemia, cigarette smoking, metabolic syndrome (MS) and obesity . However, it should be noted that the premature and accelerated development of atherosclerosis in patients with HS is independent of these CV risk factors . This fact suggests that HS itself may be an independent risk factor for atherosclerotic CV disease, and that other disease‐related factors may be implicated in the premature development of the atherogenic process in HS patients.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Insulin resistance in hidradenitis suppurativa: a case–control study

Vilanova

Hernández

Mata

et al. 2018

Acad Dermatol Venereol

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Section: Introductionsupporting

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Insulin resistance in hidradenitis suppurativa: a case–control study

Vilanova

Hernández

Mata

et al. 2018

Acad Dermatol Venereol

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“…Additional references were identified from reference lists. After application of inclusion and exclusion criteria, 12 studies were included in the systematic review and meta‐analysis (Table ), of which 5 studies had adjusted effect sizes available for extraction. The included study characteristics and demographics of these studies are summarized in Table .…”

Section: Resultsmentioning

confidence: 99%

Hidradenitis suppurativa and diabetes mellitus: updated systematic review and adjusted meta‐analysis

2019

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Summary Background Hidradenitis suppurativa (HS) is a debilitating and distressing chronic inflammatory skin disease. There is also evolving evidence supporting the association between HS and cardiovascular risk factors, including smoking, obesity, hyperlipidaemia and metabolic syndrome. Notably, these are clinical features and risk factors that are closely associated with type 2 diabetes mellitus (DM). Aims We performed a pooled adjusted meta‐analysis of comparative studies to investigate the relationship between HS and DM. Methods A systematic review and meta‐analysis was performed according to recommended Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines. OR was used as the summary effect size. Results From pooled analysis of unadjusted data from 12 studies, we found a significantly higher proportion of DM in HS cases compared with non‐HS healthy controls (16.1% vs. 15.7%; OR = 2.17; 95% CI 1.85–2.55; P < 0.001). Adjusted effect sizes from five studies were also pooled. A significantly higher proportion of DM was found for HS compared with healthy controls, although the effect size was attenuated compared with unadjusted analyses (OR 1.69; 95% CI 1.50–1.91; P < 0.001). Conclusions To our knowledge, our systematic review and meta‐analysis is the first to pool adjusted effect sizes. We found that HS was associated with a 1.69‐fold increased odds of diabetes; however, the absolute risk difference was small (16.1% vs. 15.7%) and is probably not clinically relevant. Treating clinicians should be aware of this association, but there may not be an urgent need to perform screening for impaired glucose tolerance or diabetes.

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“…Pascual et al . performed a prospective case‐control study of HS cases vs. controls, with a primary aim of assessing subclinical atherosclerosis using carotid ultrasound.…”

Section: Resultsmentioning

confidence: 99%

Hidradenitis suppurativa and metabolic syndrome – systematic review and adjusted meta‐analysis

2019

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Background Hidradenitis suppurativa (HS) is a debilitating and distressing chronic systemic inflammatory skin disease. There have been several prior observational studies which reported a possibility link between HS and metabolic syndrome, however the current evidence is not definitive. It is unclear in HS whether this possible relationship is independent or driven by underlying risk factors and comorbidities. Objective To determine whether HS is independently associated with metabolic syndrome via adjusted meta‐analysis of case‐control studies. Methods A systematic review and meta‐analysis was performed according to PRISMA guidelines. Electronic searches were performed using six electronic databases (Ovid Medline, PubMed, CCTR, CDSR, ACP Journal Club, and DARE) from their inception until September 2018. Data were extracted and analyzed according to predefined clinical endpoints. Results We identified six case‐control studies included for meta‐analysis. Based on unadjusted analysis, we found a significant association between adult cases of HS and metabolic syndrome (OR 1.95, 95% CI 1.31–2.89, P = 0.001). Adjusted meta‐analysis, after adjustment for age, sex, other cardiovascular risk factors, and comorbidities, found a significant association (OR 2.19, 95% CI 1.70–2.81, I2 = 32%, P < 0.00001). Limitations Studies reviewed were observational by design which are susceptible to bias, and there was lack of randomization. The quality of the current systematic review is also limited by the quality of available evidence which was predominantly observational in nature. Conclusions This pooled analysis of existing case‐control studies supports an association between HS and metabolic syndrome. Clinicians treating patients with HS should be aware of this potential association.

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Assessment of subclinical atherosclerosis in hidradenitis suppurativa

Abstract: Our clinical results indicate that patients with HS have a higher prevalence of subclinical atherosclerosis than expected when correcting for traditional risk factors. The findings support the conclusions of previous epidemiological studies.

Cited by 29 publications

References 30 publications

Insulin resistance in hidradenitis suppurativa: a case–control study

Insulin resistance in hidradenitis suppurativa: a case–control study

Hidradenitis suppurativa and diabetes mellitus: updated systematic review and adjusted meta‐analysis

Hidradenitis suppurativa and metabolic syndrome – systematic review and adjusted meta‐analysis

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