Assessment of Ropivacaine as a Local Anesthetic for Skin Infiltration in Skin Surgery

Abstract

Ropivacaine has a rapid onset and long duration of action. Ropivacaine produces vasoconstriction which may be clinically relevant. Even at maximum strength ropivacaine is less painful to inject than lidocaine with epinephrine.

Lignocaine versus ropivacaine infiltration for postpartum perineal pain

“…observed prolonged analgesic effect with ropivacaine (12 h) given by subcutaneous infiltration as compared to lignocaine (2 h). [20] We also found significantly prolonged analgesia with ropivacaine as compared to lignocaine (10 vs. 2 h). Gutton et al .…”

“…[16171819202122] The usefulness of ropivacaine (0.75%) infiltration has been reported for postepisiotomy pain relief in the study by Bolandard et al ., and found prolonged analgesia and TFA demand was 10 h which is concordant with this study. [18] Another study by Schinkel et al ., who did not demonstrate any significant difference in analgesia with ropivacaine, lignocaine, or saline.…”

“…[1617] Other interesting factor about ropivacaine is that lesser dermal injection pain as compared to lignocaine, this may be beneficial for patients cooperation while infiltrating. [20]…”

Effects of the Local Anaesthetic Ropivacaine on Vascular Reactivity in the Mouse Perfused Mesenteric Arteries

“…The introduction of the amide local anaesthetic, ropivacaine to clinical practice in 1996 has promoted interest in this anaesthetic, especially because it has been reported to be less neurotoxic and cardiotoxic than other long‐acting local anaesthetics (McClure 1996; Knudsen et al 1997; Heavner 2002). This pure S(‐)‐enantiomer of 1‐propyl‐2′,6′‐pipecoloxylidine is marketed for use as an extradural anaesthetic for major nerve blockade and for infiltration analgesia (Moffitt et al 2001; Whiteside & Wildsmith 2001). Because most of the local anaesthetics exert direct vasodilation, the vasoconstrictor epinephrine is often added to local anaesthetics to decrease the rate of drug absorption and to prolong the duration of the anaesthesia (Sisk 1992).…”

“…However, it has been shown by others (Cederholm et al 1994; Weber et al 2001) and recently by us (Oliveira et al 2006) that the addition of a vasoconstrictor to ropivacaine has no beneficial effect. Moreover, plain ropivacaine was shown to produce vasoconstriction locally in the skin (Kopacz et al 1989; Cederholm et al 1994; Moffitt et al 2001), cerebral arteries (Ishiyama et al 1997; Iida et al 2001) and coronary arteries (Burmester et al 2005). However, the vascular effect of ropivacaine on other vascular beds and the mechanisms by which this anaesthetic affects vascular tone is not clearly understood.…”