Assessment of risk for substance use disorder consequent to consumption of illegal drugs: Psychometric validation of the neurobehavior disinhibition trait.

Abstract

Previous research has shown that the trait neurobehavior disinhibition (ND), which consists of affect, behavior, and cognitive indicators of self-regulation, is a significant predictor of substance use disorder (SUD) between childhood and young adulthood. The authors evaluated the psychometric properties of the ND trait in 278 boys evaluated at ages 10-12 and 16 years. ND score significantly predicted SUD and outcomes that commonly manifest in tandem with SUD by age 19, such as violence, arrests, committing crime while intoxicated, and concussion injury. In addition to predictive validity, the ND trait was found to have good construct, discriminative, and concurrent validity, as well as good test-retest and internal reliability. The ND trait may be useful for detecting youths at high risk for developing SUD and related outcomes.

Sensation seeking and executive deficits in relation to alcohol, tobacco, and marijuana use frequency among university students: Value of ecologically based measures

“…The majority of research examining executive function among addicts compares addicted populations and matched controls offering little insight into the origin of executive deficits (Lyvers, Carlopio, Bothma, & Edwards, 2013;Selby & Azrin 1998). A series of longitudinal studies spanning childhood to early adulthood examining neurobehavioral disinhibition, thought to be mediated by the frontal cortex, have been found to predict substance use and substance use disorder particularly in those with a parental history of drug problems (Kirisci, Tarter, Mezzich &Vanyukov, 2007;McNamee, Dunfee, Luna, Clark, Eddy, & Tarter, 2008;Mezzich, Tarter, Feske, Kirisci, McNamee, & Day, 2007). Executive deficits have been observed in recreational users suggesting these deficits predate the development of addiction (Kollins, 2003;Soar, Mason, Potton & Dawkins, 2012).…”

Reciprocal Influence of Parent Discipline and Child's Behavior on Risk for Substance Use Disorder: A Nine-Year Prospective Study

“…Only the oldest son in the 10-12 year age range participated to avoid biased results associated with correlated data. The recruitment, screening, and consent procedures as well as inclusion and exclusion criteria for participation in the study have been described elsewhere (3)(4)(5)(6).…”

“…Other studies have documented the psychometric validity of the ND trait (6) and demonstrated its utility for predicting adolescent behaviors that, in turn, predict SUD in young adulthood (7)(8)(9). Considered in aggregate, the result of genetic (10)(11)(12)(13), neurophysiological (12), and psychological (4)(5)(6)13) investigations indicate that deficient inhibitory control amplifies SUD risk.…”

“…Genetically informative investigations also indicate that deficient psychological self-regulation, evinced as behavior undercontrol and heightened emotionality, comprises a cardinal transmissible feature of SUD liability (2). Research conducted in our laboratory has revealed that a trait termed neurobehavior disinhibition (ND), consisting of measures of executive cognitive function, behavior undercontrol, and emotion regulation, discriminates youths at high and low risk for SUD as well as predicts SUD outcome between childhood and young adulthood (3)(4)(5)(6). Other studies have documented the psychometric validity of the ND trait (6) and demonstrated its utility for predicting adolescent behaviors that, in turn, predict SUD in young adulthood (7)(8)(9).…”

“…Research conducted in our laboratory has revealed that a trait termed neurobehavior disinhibition (ND), consisting of measures of executive cognitive function, behavior undercontrol, and emotion regulation, discriminates youths at high and low risk for SUD as well as predicts SUD outcome between childhood and young adulthood (3)(4)(5)(6). Other studies have documented the psychometric validity of the ND trait (6) and demonstrated its utility for predicting adolescent behaviors that, in turn, predict SUD in young adulthood (7)(8)(9). Considered in aggregate, the result of genetic (10)(11)(12)(13), neurophysiological (12), and psychological (4)(5)(6)13) investigations indicate that deficient inhibitory control amplifies SUD risk.…”