ASSESSMENT OF POSSIBLE TOXIC EFFECTS OF POLYVINYLPYRROLIDONE‐IODINE UPON THE HUMAN EYE IN CONJUNCTION WITH CATARACT EXTRACTION An Endothelial Specular Microscope Study

Wille, Henrik

doi:10.1111/j.1755-3768.1982.tb00627.x

Cited by 32 publications

(5 citation statements)

References 8 publications

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“…It is remarkable and in favour of the use of PVP-I as an ocular desinfectant, that all 4 panophthalmia were found in the group of patients not treated with PVP-I (group A). The characteristics of PVP-I found bv other authors is: no penetrating through the epithelium, broad antibacterial spectrum, inactivating of several viruses, short killing time rate, no damaging of the corneal surface or the endothelium (Hale 1969;Gluud 1984;Wille 1982), and the fac t that we did not find any toxic or…”

Section: Discussionsupporting

confidence: 65%

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The effect of polyvinylpyrrolidone‐iodine as an desinfectant in eye surgery

Klie

Bøge‐Rasmussen

Jensen

1986

Acta Ophthalmologica

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105 patients admitted for cataract surgery were treated pre-operatively with polyvinylpyrrolidone-iodine (PVP-I) as a disinfectant, and consecutive bacterial cultures were obtained before initiating surgery and at the end of the operation. A control group (n = 99) only had a standard disinfection procedure of the eye (including instillation of Terramycin cum polymyxin B cream in the conjunctival sac the evening before surgery). The cultures obtained from the conjunctival sac of the control group principally showed growth of Staph. albus and Staph. aureus, and to a minor degree diphtheroids (Corynebacterium species). Proteus mirabilis, Escherichia coli and micrococci. There was a significant quantitative diminished growth (P less than 0.05) of bacteria in the group of patients treated with PVP-I compared to the control group. Concerning the growth of Staph. albus, this was reduced to almost one third and other bacteria were almost eliminated in the group receiving PVP-I. As we disclosed no toxic or allergic reaction post-operatively which could be related to the use of PVP-I as a disinfectant, this agent seems to constitute an effective pre-operative antimicrobial treatment, taking into consideration the broad antimicrobial spectrum of PVP-I shown by other authors.

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Section: Discussionsupporting

confidence: 65%

“…1964). N o toxicity or irritation of the ocular tissues has in any case been observed (Wille 1982;Gluud 1984) but a substantial lethality to a variety o f bacteria a n d a n inactivating effect to virus have been found after the use of PVP-I (Hale 1969; Hale e t al. 1969;Plotkin 1969).…”

mentioning

confidence: 99%

The effect of polyvinylpyrrolidone‐iodine as an desinfectant in eye surgery

Klie

Bøge‐Rasmussen

Jensen

1986

Acta Ophthalmologica

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“…[ 30 ] Wille (1982) evaluated corneal swelling with pachymetry and endothelial cell loss with specular microscopy following cataract surgery and observed no increased postoperative corneal swelling when PI was used. [ 31 ] In the current study, there was no significant change in CCT after PI instillation in either group, but patient follow-up in the study was short. Of note, no patient demonstrated evidence of corneal toxicity during routine follow-up examinations in our department for at least two years after study completion.…”

Section: Discussionmentioning

confidence: 54%

Comparative efficacy of two different topical povidone-iodine 5% regimens in reducing conjunctival bacterial flora: A randomized parallel double-masked clinical trial

Barroso¹,

Cazella²,

Nepomuceno³

et al. 2017

PLoS ONE

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IntroductionThe increasing prevalence of multi-resistant bacteria is a major public health concern. Infections acquired during ophthalmic surgery are devastating. The purpose of the current study is to compare the proportion of eyes with negative bacterial cultures on all tested media after 1 versus 3 sequential drops of povidone-iodine (PI) 5% into the inferior conjunctival fornix.MethodsPatients were randomly assigned to receive 1 (PI group) drop (at time 28 minutes) or 3 (PI plus group) sequential drops (at time 0, 20 minutes and 28 minutes) of PI 5% into the inferior conjunctival sac of one randomly selected eye. A swab culture was obtained from the inferior conjunctival fornix 5 minutes before and 30 minutes after time 0. Central corneal thickness (CCT) was measured shortly before time 0 and shortly after time 30. Conjunctival swabs were incubated aerobically in enriched Thioglycolate liquid medium (meat broth) and in three solid culture media (chocolate agar, trypticase soy agar with 5% sheep blood, and Sabouraud agar).ResultsThere was no significant difference in the proportion of negative cultures after intervention between groups (p = 0.1638). Also in the PI group (n = 59), the proportion of eyes with negative cultures after PI (79.7%) did not differ significantly from baseline (76.3%; p = 0.7539). However in the PI plus group (n = 61), the proportion of eyes with all negative cultures after PI (85.3%) was significantly higher than before PI (70.5%) (p = 0.0177). There was no significant difference in mean CCT before and after the intervention in both groups.ConclusionInstillation of 3 sequential drops of PI was associated with a significant increase in the proportion of eyes with all negative cultures, while instillation of a single drop of PI was not associated with a significant increase in the proportion of negative cultures. Further study is warranted to determine whether the difference between the PI administration regimens is also associated with differences in the rates of postoperative ocular infections.

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“… 7 , 20–22 Povidone-Iodine also retards wound healing in rabbit models, 23 though no cytotoxic effects on the cornea were observed in patients undergoing cataract surgery. 24 We speculate that 2–3% povidone-iodine may be a good compromise between the more effective 5% solution and safer 1% solution. Our study is unable to identify whether soaking of buckle elements in povidone-iodine or gentamicin alters the rate of contamination by ocular flora after buckle placement.…”

Section: Discussionmentioning

confidence: 92%

Comparison of Povidone-Iodine and Gentamicin Soak as Scleral Buckle Infection Prophylaxis

Lin

Lee

et al. 2021

OPTH

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Objective To determine the best method of antimicrobial prophylaxis against implanted material-associated infections in the setting of scleral buckle surgery. Design Experimental study. Participants Scleral buckle elements were soaked in either gram-positive or polymicrobial broth, while control buckle elements were soaked in PBS only. Methods Solid silicone and sponge scleral buckle elements were inoculated with common pathogens of the ocular surface, and then soaked in either 1% or 5% povidone-iodine, 1 mg/mL gentamicin solution, or sterile saline for 1, 5, 10, or 15 minutes. Bacteria were then isolated from the buckle elements and cultured for 24 hours. Results In all gram-positive bacterial conditions, gentamicin solution decreased the bacterial load from 451,666.67 colony-forming units (CFU)/mL to 171,611.11 CFU/mL (p=0.0004). The fractional bacterial survival after soaking in gentamicin was higher for the silicone sponge than band (0.357 vs 0.079, p=0.038). Both 1% and 5% povidone-iodine were able to completely eradicate all gram-positive bacteria of both buckle elements. Only 5% povidone-iodine was able to completely sterilize all microbes on the buckle after soaking in a polymicrobial solution consisting of gram-positive, gram-negative bacteria, and fungi. Conclusion Povidone-iodine solution was significantly more effective at bacterial eradication compared to gentamicin solution. For all scleral buckle procedures, we recommend soaking the buckle element in 2–3% povidone-iodine solution before placement and rinsing the ocular surface with the same solution after placement.

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ASSESSMENT OF POSSIBLE TOXIC EFFECTS OF POLYVINYLPYRROLIDONE‐IODINE UPON THE HUMAN EYE IN CONJUNCTION WITH CATARACT EXTRACTION An Endothelial Specular Microscope Study

Cited by 32 publications

References 8 publications

The effect of polyvinylpyrrolidone‐iodine as an desinfectant in eye surgery

The effect of polyvinylpyrrolidone‐iodine as an desinfectant in eye surgery

Comparative efficacy of two different topical povidone-iodine 5% regimens in reducing conjunctival bacterial flora: A randomized parallel double-masked clinical trial

Comparison of Povidone-Iodine and Gentamicin Soak as Scleral Buckle Infection Prophylaxis

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