Assessment of Monocyte to High Density Lipoprotein Cholesterol Ratio and Lymphocyte-To-Monocyte Ratio in Patients With Metabolic Syndrome

Demir, Vahit; Akboğa, Mehmet Kadri; Yılmaz, Samet; Ede, Hüseyin

doi:10.2217/bmm-2016-0380

Cited by 68 publications

(73 citation statements)

References 26 publications

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“…42,43 Although the data on the MHR are limited, some studies revealed that MHR was also an important and valuable variable for cardiovascular events and MetS. 44,45 In another study, it was found that MetS can involve changes in blood parameters, and the lymphocyte to HDL-C ratio may be a useful marker of inflammation to assess the presence and severity of MetS. 14 In summary, in this study, two novel and independent hematological parameters were found.…”

Section: Discussionmentioning

confidence: 53%

<p>Comparison of the Value of Neutrophil to High-Density Lipoprotein Cholesterol Ratio and Lymphocyte to High-Density Lipoprotein Cholesterol Ratio for Predicting Metabolic Syndrome Among a Population in the Southern Coast of China</p>

Chen¹,

Chen²,

Tang³

et al. 2020

DMSO

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Background: This study aimed to determine the optimal cutoff values and evaluate the associations of neutrophil to high-density lipoprotein cholesterol ratio (NHR) and lymphocyte to high-density lipoprotein cholesterol ratio (LHR) with metabolic syndrome (MetS), stratified by sex. Methods: A large-scale cross-sectional survey was conducted among 1401 adults from January to April 2018 in six communities in Wanzhai Town, Zhuhai City, on the southern coast of China. Receiver operating characteristics (ROC) analyses and logistic regression analysis were conducted to assess the optimal cutoff and value of NHR and LHR for predicting MetS. Results: Hematological parameters showed the correlation with the occurrence of MetS (red blood cells, hemoglobin, and white blood cells and subtypes). Binomial logistic regression analysis found that LHR (OR: 3.671; 95% CI: 2.385-5.651; p<0.001) and NHR (OR: 1.728; 95% CI: 1.353-2.207; p<0.001) can predict MetS in females, independent of confounding factors. Although LHR (OR: 1.571; 95% CI: 1.001-2.468; p=0.05) and NHR (OR: 1.163; 95% CI: 0.909-1.48; p<0.01) were independent risk factors for MetS in males after adjustment for age, current smoking, current alcohol use, physical activity, educational attainment, waist circumference, systolic pressure, diastolic pressure and hypersensitive C-reactive protein (hs-CRP), when further adjusted for fasting plasma glucose level, LHR and NHR, both lost their independence. ROC curves showed that LHR had the highest AUC for predicting MetS in females and NHR had the highest AUC in males. The cutoff points of LHR and NHR were 1.36 and 2.31 in females, and 1.96 and 3.38 in males. Conclusion: LHR and NHR may become valuable makers and have strong predictive power for predicting MetS, especially in females.

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Section: Discussionmentioning

confidence: 53%

<p>Comparison of the Value of Neutrophil to High-Density Lipoprotein Cholesterol Ratio and Lymphocyte to High-Density Lipoprotein Cholesterol Ratio for Predicting Metabolic Syndrome Among a Population in the Southern Coast of China</p>

Chen¹,

Chen²,

Tang³

et al. 2020

DMSO

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“…A new prognostic factor in cardiovascular disease, the ratio of monocytes to high-density lipoprotein (MHR), has recently been recommended and could be used as an indicator of infl ammation. Elevated MHR levels were associated with cigarette smoking , obesity and muscular bridge diagnosed with coronary anjiography (4,14,15). The activation of monocytes and their differentiated forms into lipid-laden machropages plays a signifi cant role in the promotion of immune defense and also drives infl ammation and cardiovascular disease (1,3,9).…”

Section: Discussionmentioning

confidence: 99%

Monocyte to high-density lipoprotein ratio: a prognostic factor for mitral valve prolapse?

Abacıoğlu¹

2021

BLL

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BACKGROUND: Mitral valve prolapse (MVP) is a common disorder, affl icting 2 % to 3 % of the general population. Despite the general belief of a benign disorder, there is an increasing awareness of an association between mitral valve prolapse and sudden cardiac death from arrhythmia and also atherosclerosis. Monocyte to high density lipoprotein ratio (MHR) is a new tool for predicting infl ammation, which plays a major role in atherosclerosis. OBJECTIVE: To evaluate the relationship between MHR and the presence of MVP. METHODS: The study population consisted of 82 patients with MVP and the control group of 78 normal individuals. Transthoracic echocardiograpy was performed for all of the study population and peripheral venous blood samples were drawn for measuring MHR and other haemotological parameters. RESULTS: The patients with MVP were more likely to have higher MHR values (15.82 ± 6.01 in MVP patients and 13.30 ± 6.43 in controls; p=0.011). Monocyte counts and MHR of the MVP group were signifi cantly higher than the control group and MHR values were directly proportional with the regurgitation area. CONCLUSION: The MHR is strongly associated with MVP and regurgitation area and might be a prognostic factor for patients with MVP

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“…Then monocytes differentiate into macrophages and these macrophages start to phagocytes of oxidized LDL and become foam cells [15,16]. Previous studies have been associated with the severity of coronary artery disease and low LMR and high MHR has been regarded as a surrogate marker for endothelial dysfunction and inflammation [17,18]. In this study, first time in the literature, drug naïve MetS patient's value of the LMR and MHR were compared the healthy age and BMI matched ones.…”

Section: Discussionmentioning

confidence: 97%

Association of inflammation markers with epicardial adipose tissue in drug naive metabolic syndrome

Kırbaş¹

2018

Ann Clin Anal Med

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The metabolic syndrome (MetS) or syndrome X is a serious health problem effecting an increasing number of person worldwide. In the present study, the aim was to investigate whether there is an association among epicardial adipose tissue thickness, insulin resistance, lymphocyte to monocyte ratio (LMR) and monocyte count-to-high density lipoprotein cholesterol ratio (MHR) levels in drug naïve patient with metabolic syndrome. Twenty-two consecutive drug-naïve women diagnosed with MetS and 30 age matched consecutive healthy women (as the control group) were recruited into the study. MHR was significantly higher [12.1

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Assessment of Monocyte to High Density Lipoprotein Cholesterol Ratio and Lymphocyte-To-Monocyte Ratio in Patients With Metabolic Syndrome

Abstract: The present study shows that both LMR and MHR may be novel and useful indicators of MS.

Cited by 68 publications

References 26 publications

<p>Comparison of the Value of Neutrophil to High-Density Lipoprotein Cholesterol Ratio and Lymphocyte to High-Density Lipoprotein Cholesterol Ratio for Predicting Metabolic Syndrome Among a Population in the Southern Coast of China</p>

<p>Comparison of the Value of Neutrophil to High-Density Lipoprotein Cholesterol Ratio and Lymphocyte to High-Density Lipoprotein Cholesterol Ratio for Predicting Metabolic Syndrome Among a Population in the Southern Coast of China</p>

Monocyte to high-density lipoprotein ratio: a prognostic factor for mitral valve prolapse?

Association of inflammation markers with epicardial adipose tissue in drug naive metabolic syndrome

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