Assessment of IL-17F rs763780 gene polymorphism in immune thrombocytopenia

Tolba, Fetnat; Diab, Safia M; Abdelrahman, A.M.; Behairy, Ola Galal; Almonaem, Eman Rateb Abd; Mogahed, Mysara M.; Mohamed, S. A.

doi:10.1016/j.bcmd.2018.12.001

Cited by 10 publications

(8 citation statements)

References 34 publications

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“…In rheumatoid arthritis, no association was detected 56&57 . In contrast, IL-17F gene polymorphism is linked to inflammatory bowel disease 29,58 , asthma 24 , MS 59 , ITP 60 , recurrent pregnancy loss 61 and AITDs 27 .…”

Section: Discussionmentioning

confidence: 97%

Il-17f Gene Polymorphism (7488t/C, Rs763780) in Egyptian Patients With Sle

El-Sherbini

AbdAlRaouf²,

El‐Masry³

et al. 2022

Bulletin of Pharmaceutical Sciences. Assiut

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Systemic Lupus erythematosus (SLE) is a worldwide autoimmune disease with different presentations. Genetic and environmental factors like infection and ultraviolet light are supposed to be responsible for the development of SLE. Disturbance in cytokines production may be involved in SLE pathogenesis. In this case-control study, we investigate the interleukin-17F (IL-17F) gene polymorphism (7488T/C, rs763780) in Egyptian SLE patients using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). There were no significant changes when both genotypes and alleles for patients and controls were compared with each other. According to the results, no association between the IL-17F gene polymorphism (7488T/C, rs763780) and SLE.

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Section: Discussionmentioning

confidence: 97%

Il-17f Gene Polymorphism (7488t/C, Rs763780) in Egyptian Patients With Sle

El-Sherbini

AbdAlRaouf²,

El‐Masry³

et al. 2022

Bulletin of Pharmaceutical Sciences. Assiut

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“…Several meta-analysis demonbstrated the relationship between gene polymorphisms of IL-17A (rs2275913) and IL-17F (rs763780) and the pathogenesis of in ammatory diseases, including periodontitis, SLE, golomerulonephritis, rheumatoid arthritis (RA), and in ammatory bowel disease [12]. Research also reported polymorphism of IL17A (rs2275913) is associated with osteitis after the Bacillus Calmette-Guérin vaccination [18,19], and a variant of IL17F (rs763780) may participate in the development of immune thrombocytopenia [20] and necrotizing enterocolitis [21]. All these researches indicate that IL17 polymorphisms are possibly associated with immune mediated diseases widely.…”

Section: Discussionmentioning

confidence: 99%

Correlation study between Interleukin-17 Gene Polymorphisms and risk of development of recurrent aphthous ulcer in Han Chinese Population

Xiang

Cheng

Guo

et al. 2020

Preprint

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ObjectiveInterleukin-17 (IL-17) is a pleiotropic cytokine which plays important role in the inflammatory diseases.MethodsPolymorphisms of IL-17A rs2275913 and IL17F rs763780 were measured in 125 RAU cases and 116 healthy controls. The polymerase chain reaction-restriction fragment length was measured. The genotype distribution and disease risk, and its’ relationship with RAU severity was analyzed.ResultsRAU risk were related with polymorphism of IL-17 gene at rs2275913 site after adjusting BMI, sex, age, smoking and drinking status (AA vs. GG: odds ratio (OR), 1.624; 95% confidence interval (CI), 1.125–2.250; P = 0.030; A allele vs. G allele: OR, 1.192; P = 0.037; 95% CI, 1.012–1.404;). In addition, the rs763780 variant genotypes (TC and CC) and C allele also have higher relevance to RAU compared with subjects who bears the TT genotype (TC vs. TT, OR: 1.312; P = 0.039; 95% CI: 1.017–1.692; CC vs. TT, OR: 2.812, P = 0.006, 95% CI: 1.338-5.909; C allele Vs. T allele, OR:1.413, P=0.002, 95% CI:1.141-1.751). We also found serum IL-17 levels were greatly higher in RAU patients compared with controls (P = 0.001), and serum IL17 concentration is correlated with IL17 polymorphism.ConclusionOur research showed polymorphisms of IL-17 gene might related to the high-risk of RAU occurrence.

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“…The inflammation cytokine IL17F is involved in innate and adaptive immune responses. Previous studies have indicated that IL17F is associated with a variety of inflammatory diseases, such as immune thrombocytopenia, severe enterovirus infection and aphthous stomatitis 7‐9 . Vrgoc et al 10 found that the T allele of rs763780 in IF17F was associated with a lower risk for developing HOA, whereas the C allele was associated with susceptibility to HOA Specifically, the genotype T/T of IF17F was associated with protection against HOA, but the genotype T/C was associated with a higher risk of acquiring HOA in a Croatian population.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have indicated that IL17F is associated with a variety of inflammatory diseases, such as immune thrombocytopenia, severe enterovirus infection and aphthous stomatitis. [7][8][9] Vrgoc et al 10 found that the T allele of rs763780 in IF17F was associated with a lower risk for developing HOA, whereas the C allele was associated with susceptibility to HOA Specifically, the genotype T/T of IF17F was associated with protection against HOA, but the genotype T/C was associated with a higher risk of acquiring HOA in a Croatian population. Most recently, a genetic epidemiology study of HOA found that the IL17A-IL17F haplotype (rs2275913-rs763780-rs1889570) G-C-A confers predisposition to HOA, and the IL17A-IL17F haplotype (rs2275913-rs763780) G-T is associated with protection from HOA in a Croatian population.…”

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confidence: 99%

Common variants in IL17F gene contributed to the risk of hip osteoarthritis susceptibility in Han Chinese population

Zhao

Wang

et al. 2020

Int J of Rheum Dis

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Osteoarthritis (OA) is a chronic degenerative joint disease that is characterized by articular cartilage loss, synovial inflammation and structural changes in the subchondral bone. 1 This type of derangement and destruction of joint integrity in OA occurs in the knee and hip in humans and shows clinical symptoms, such as joint pain, dysfunction, stiffness, activity limitations and physical disability. 2 Primary hip osteoarthritis (HOA) is defined as degeneration of the tissues of the hip joint, including hyaline cartilage, fibrocartilage, bone, and synovium. 3 According to the literature, HOA is virtually absent in Black Africans and is consistently rare in non-European populations but occurs at a rate of 3% to 6% in populations with European ancestry. 4 In addition to the interplay of obesity, joint injury, excessive occupational joint load, and sports activity, which represent environmental factors in patients, HOA is indicated to be a genetic disease with a 50% heritability caused

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Assessment of IL-17F rs763780 gene polymorphism in immune thrombocytopenia

Cited by 10 publications

References 34 publications

Il-17f Gene Polymorphism (7488t/C, Rs763780) in Egyptian Patients With Sle

Il-17f Gene Polymorphism (7488t/C, Rs763780) in Egyptian Patients With Sle

Correlation study between Interleukin-17 Gene Polymorphisms and risk of development of recurrent aphthous ulcer in Han Chinese Population

Common variants in IL17F gene contributed to the risk of hip osteoarthritis susceptibility in Han Chinese population

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