Common variants in IL17F gene contributed to the risk of hip osteoarthritis susceptibility in Han Chinese population

Abstract

Osteoarthritis (OA) is a chronic degenerative joint disease that is characterized by articular cartilage loss, synovial inflammation and structural changes in the subchondral bone. 1 This type of derangement and destruction of joint integrity in OA occurs in the knee and hip in humans and shows clinical symptoms, such as joint pain, dysfunction, stiffness, activity limitations and physical disability. 2 Primary hip osteoarthritis (HOA) is defined as degeneration of the tissues of the hip joint, including hyaline cartilage, fibrocartilage, bone, and synovium. 3 According to the literature, HOA is virtually absent in Black Africans and is consistently rare in non-European populations but occurs at a rate of 3% to 6% in populations with European ancestry. 4 In addition to the interplay of obesity, joint injury, excessive occupational joint load, and sports activity, which represent environmental factors in patients, HOA is indicated to be a genetic disease with a 50% heritability caused

Osteoarthritis year in review: genetics, genomics, epigenetics

“…To resolve this Lee and Song conducted a meta-analysis of eight studies and concluded that rs2275913 in IL17A and rs763780 in IL17F are associated with general OA, but the latter not with hip OA (HOA) 13 . However in a more recent study, rs763780 was associated with HOA in a Han Chinese population 14 , indicating that perhaps ethnicity is partially responsible for the contradictory associations of IL17 genes with OA.…”

IL17F: A Possible Risk Marker for Spondyloarthritis in HLA-B*27 Negative Brazilian Patients

“…The IL17F rs763780 C allele has been associated to an increased risk of autoimmune and inflammatory diseases such as rheumatoid arthritis in Tunisian population [32], inflammatory arthritis in a meta-analysis conducted in Caucasians [33], hip osteoarthritis in Han Chinese [34], knee osteoarthritis in Iranians [35], and psoriasis an Asians [36]. Regarding SpA, the IL17F polymorphism was associated with susceptibility to AS, disease activity and functional status in Turk patients [37], and a risk factor for SpA, AS and PsA in Brazilians [13].…”