Assessment of cognitive functions in tramadol-dependent patients

Khalifa, Hosam; Darweesh, Alaa El-Din M.; Hassaan, Shehab H; Mostafa, Sayed

doi:10.1097/01.xme.0000526928.54570

Cited by 5 publications

(5 citation statements)

References 16 publications

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“…Our results were in line with those of a study conducted by Khalifa and colleagues [ 24 ]. In this study, 30 tramadol-dependent people were examined and compared with healthy controls regarding cognitive functions.…”

Section: Discussionsupporting

confidence: 94%

Evaluation of the executive functions and quality of life in a sample of Egyptian male adolescents with substance use disorder: A case-control study

Sonbol,

Sabri,

Shahda

et al. 2024

Discov Ment Health

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Background Adolescent substance use is a major problem that has serious medical, psychological, and legal consequences later in life. Substance use disorder is closely linked to deficits in executive functions. Impaired executive functions (EFs) have been linked to all stages of the substance use disorder (SUD) life cycle, increasing the likelihood of commencing use, escalating use more quickly, and increasing the likelihood of relapsing following treatment. The current study aimed at evaluating of the executive functions and quality of life in a sample of adolescent Egyptian males with substance use disorder. Results A significantly higher mean Trail Making Test-A, B (TMT-A and TMT-B) scores among studied cases than the control group (equals lower executive functions) with a mean score of TMT-A is 74.38 versus 63.2 among controls and for TMT-B; the mean score for control is 97.22 versus 142.04 among cases. A statistically significant difference between the case and control groups on all quality of life scores measuring the following domains: general health and well-being, physical health, psychological health, social interactions, and the environment, also there has been a negative correlation between TMT-A and the environmental domain (r = − 0.279) and TMT-B with the same variable (r = − 0.414). Conclusions Substance use disorders are a major health problem among youth. Deficits in executive functions are strongly associated with adolescent substance use. The more affected executive functions are associated with more affected quality of life of these patients.

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Section: Discussionsupporting

confidence: 94%

Evaluation of the executive functions and quality of life in a sample of Egyptian male adolescents with substance use disorder: A case-control study

Sonbol,

Sabri,

Shahda

et al. 2024

Discov Ment Health

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“…In this study, the mean duration of addiction was 9.23±3.45 years. The most frequently used substances were tramadol (20%), other opioids (24%), and cannabis (12%), which is consistent with the report of the National Survey of Addiction performed in 2015, and also it consolidates the findings of previous relevant Egyptian studies, which emphasize the rise of tramadol addiction in Egypt to replace cannabis as the most used substance of addiction in Egypt 15,16…”

Section: Discussionsupporting

confidence: 89%

“…The most frequently used substances were tramadol (20%), other opioids (24%), and cannabis (12%), which is consistent with the report of the National Survey of Addiction performed in 2015, and also it consolidates the findings of previous relevant Egyptian studies, which emphasize the rise of tramadol addiction in Egypt to replace cannabis as the most used substance of addiction in Egypt. 15,16 On studying the decision-making and impulsivity, it has been noticed that the patients' group had a significantly higher IGT-A (P<0.001) and IGT-B (P = 0.02) scores indicating that addictive behavior is associated with increased risky choices and preference for immediate short-term gain even if it was associated with risk of monetary loss as in both groups (A and B). The patients' group shows significant higher impulsivity than the control group as parameters of UPPS were significantly higher (P<0.001).…”

Section: Discussionmentioning

confidence: 98%

Impulsivity and Decision-making Style Among Tramadol Drug Addicts and its Relation to Frontal Lobe Volume

Elbeh¹,

Elserogy²,

Seifeldein

et al. 2021

Addictive Disorders &Amp; Their Treatment

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Objectives: Drug addiction has its effects on different behavioral and personality traits including impulsivity and pattern of decision-making. The frontal lobe was the focus of many of these studies regarding its important role in decision-making and other higher cognitive processes. We aimed to detect the pattern of decision-making styles and impulsivity among people with tramadol addiction, and also to find out if tramadol addiction has effects on the volume of different regions of the frontal lobe. Materials and Methods: Two groups were included: group A included 12 patients with tramadol addiction and group B included 23 healthy cross-matching controls. Both groups were subjected to urine drug screening, Iowa gambling task (IGT), UPPS scales (negative urgency, lack of perseverance, lack of premeditation, and sensation seeking), and structural magnetic resonance imaging brain study. Results: The patients’ group has shown a significantly lower volume of the brain white matter, gray matter, and cortical thickness (P<0.001). This group has also shown a significantly higher scores of IGT-A and IGT-B (P<0.001 and P=0.02, respectively) and has shown a higher score of all subscales of UPPS. Conclusions: Tramadol addiction is associated with a reduced volume of the brain white matter, gray matter, and cortical thickness. All regions of the frontal lobe have shown significant volume reduction in the tramadol group. Tramadol addiction and its duration are associated with risky decision-making style and with higher impulsivity than nonaddicts.

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“…One of the reasons for this small number is that tramadol abuse potentiality has usually been considered low. Recently, it has been suggested that tramadol abuse liability may have been previously underestimated (Bassiony et al , 2015; Khalifa et al , 2018).…”

Section: Discussionmentioning

confidence: 99%

“…There is not much research in the literature about the effect of tramadol on cognitive functions as tramadol is not considered a common drug of abuse in the Western world (Khalifa et al , 2018). Studies have revealed contradictory results, mostly because of the different methodologies involved.…”

Section: Introductionmentioning

confidence: 99%

Does tramadol dependence impair cognitive functions?

Shalaby¹,

El-Seidy²,

Zayed

et al. 2022

International Clinical Psychopharmacology

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The aim of this study is to assess the effect of tramadol use on cognitive functions, especially executive functions. Thirty tramadol use disorder patients were recruited from those admitted to the toxicology departments of Menoufia University Hospitals for detoxification. Thirty controls were recruited from employees working at the faculty of medicine, Menoufia University. Both patients and controls underwent a demographic sheet and computerized cognitive battery. Patients also completed another sheet about substance use history. Urine screening for drugs was performed on all patients prior to admission. No differences regarding age, education or marital status were found between patients and controls. Tramadol-dependent patients showed cognitive impairment in the form of impaired visual-spatial memory and executive functions in comparison to controls. After detoxification, patients showed improvement regarding executive functions but not visual-spatial memory. Tramadol impairs cognitive functions in tramadol-dependent patients.

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Assessment of cognitive functions in tramadol-dependent patients

Cited by 5 publications

References 16 publications

Evaluation of the executive functions and quality of life in a sample of Egyptian male adolescents with substance use disorder: A case-control study

Evaluation of the executive functions and quality of life in a sample of Egyptian male adolescents with substance use disorder: A case-control study

Impulsivity and Decision-making Style Among Tramadol Drug Addicts and its Relation to Frontal Lobe Volume

Does tramadol dependence impair cognitive functions?

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