Assessment of carcinogenic risks to workers of the main enterprises of the Irkutsk region

Abstract

The purpose of research is the assessment of the individual cancer risk (ICR) for workers of the basic occupations in key branches of industry of the Irkutsk region. There was executed the calculation of ICR levels for workers of the basic occupations of the aircraft industry, aluminum smelters and vinyl chloride production plants. The estimation of the exposure for workers was carried out according to long-term time-weighted average concentrations in the air of the working area, for the population - on annual average concentrations in the ambient air. To assess the risk that is not associated with the profession, the dose was calculated for the period of life (70 years). When calculating the toxicant doses in the working area there were used the “standard” indices ofpulmonary ventilation for adults, body weight, the work experience in the contact with carcinogens of 30 years, the number of days in the contact of 240, the duration of the working time 8 or 12 hours (in accordance with the working hours) duration. ICR for the Irkutsk population amounted of 3.08E-04, in Shelekhov - 4.8E-05, Sayansk - 1.1E-05. The amount of risk depends on the content offormaldehyde in all territories and chromium VI in cities of Irkutsk and Shelekhov. ICR for workers of basic occupations of studied plants in dozens of times are higher than for the urban population. Priority carcinogens are: chromium VI, nickel, formaldehyde, silicon dioxide -for the aircraft plant employees; 1,2-dichloretan, vinyl chloride - for the workers of vinyl chloride production plant; benzopyrene - for the aluminum smelter workers.

Assessment of the Contribution Made by Oncogenic Factors to the Risk of Malignant Neoplasms Development for the Urban Population of Working Age

“…должны быть направлены на устранение онкогенных факторов среды обитания. В настоящее время выполнено достаточно большое количество исследований по выявлению особенностей формирования онкопатологии среди различных групп населения [7][8][9][10][11][12]. Показано, что среди многих факторов, влияющих на здоровье, большая роль принадлежит химическому загрязнению окружающей среды, характеру питания, условиям труда, быта, воспитания, образу жизни.…”

“…Показано, что среди многих факторов, влияющих на здоровье, большая роль принадлежит химическому загрязнению окружающей среды, характеру питания, условиям труда, быта, воспитания, образу жизни. По мнению ряда исследователей, доминирующую роль (до 75-80 %) в возникновении ЗН играют факторы окружающей и, в первую очередь, производственной среды [10,11]. Загрязнение атмосферного воздуха химическими веществами вызывает 41 % заболеваний органов дыхания и более 13 % онкологических заболеваний у трудоспособного населения [13].…”

“…С учетом места фактического проживания для лиц, не занятых на канцерогеноопасных производствах, оценен индивидуальный канцерогенный риск, отражающий суммарное загрязнение атмосферного воздуха веществами, обладающими онкогенными свойствами. Для работников основных канцерогеноопасных производств рассчитывали индивидуальный канцерогенный риск, отражающий суммарное загрязнение атмосферного воздуха и воздуха рабочей зоны (ICR рз ), что подробно представлено в наших работах [11,22]. Сравнение частоты явления в изучаемых группах проведено с использованием точного критерия Фишера, различия считали статистически значимыми при р < 0,05.…”

Assessment of the Contribution Made by Oncogenic Factors to the Risk of Malignant Neoplasms Development for the Urban Population of Working Age

“…Activities within such prevention should primarily be aimed at eliminating oncogenic environmental factors. At present there are multiple available research works that focus on detecting peculiarities of oncologic pathology occurrence among various population groups [7][8][9][10][11][12]. It was shown that a great contribution to adverse influence on health was made by chemical contamination of the environment, eating habits, working conditions, living conditions, education, and lifestyle.…”

“…It was shown that a great contribution to adverse influence on health was made by chemical contamination of the environment, eating habits, working conditions, living conditions, education, and lifestyle. According to several researchers, environmental factors, primarily occupational ones, play the leading role (up to 75-80 %) in MNs occurrence and development [10,11]. Ambient air pollution with chemicals is responsible for 41 % of respiratory diseases and more than 13 % of oncologic diseases among employable population [13].…”