Assessment of antioxidant, antibacterial and anti-proliferative (lung cancer cell line A549) activities of green synthesized silver nanoparticles from<i>Derris trifoliata</i>

Cyril, Neethu; George, James Baben; Joseph, Laigi; Raghavamenon, Achuthan C.; Sylas, V. P.

doi:10.1039/c8tx00323h

Cited by 70 publications

(37 citation statements)

References 66 publications

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“…The smaller the particle size is, the larger the surface area is, and more active sites for scavenging free radicals and inhibiting oxidation reaction are provided. [40] 3.8 | Antibacterial activity…”

Section: Ft-ir Analysis Of Agnpsmentioning

confidence: 99%

Monascus pigment‐mediated green synthesis of silver nanoparticles: Catalytic, antioxidant, and antibacterial activity

Zhang

Guo

et al. 2021

Applied Organom Chemis

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In order to explore green and efficient methods for the synthesis of nanoparticles, silver nanoparticles (AgNPs) were rapidly synthesized assisted by the Monascus pigments under simulated sunlight. Prepared AgNPs were characterized using various analytical tools such as ultraviolet‐visible (UV–Vis) spectroscopy, Zeta, X‐ray diffraction (XRD), scanning electron microscopy (SEM)–energy dispersive X‐ray (EDX), and Fourier‐transform infrared spectroscopy (FT‐IR). There is an absorption peak at 410 nm in the UV–Vis absorption spectrum, which confirms the formation of AgNPs. XRD results affirmed that the synthesized AgNPs were crystalline in nature and preferentially oriented in (111) plane. The morphology of the nanoparticles was found to be spherical by SEM and particle size analysis study revealed the average particle size to be 18.10 ± 0.30 nm. Zeta potential measurement showed excellent stability of AgNPs with negative values of −9.2 ± 0.66 mV. The FT‐IR study represented involvement of functional groups in AgNPs synthesis. The biosynthesized AgNPs exhibited significant antibacterial activity with zones of inhibition of 9.1, 14.5, and 18.0 mm against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus, respectively. Through the determination of hydroxyl radical scavenging capacity, ABTS radical scavenging capacity, total reducing power, and total antioxidant capacity, it is proved that the AgNPs have certain antioxidant capacity. In addition, AgNPs could catalyze the degradation of methylene blue, methyl orange, and congo red with a pseudo first‐order rate constants of 0.07998, 0.24666, and 0.11805 min−1, respectively. Overall studies indicated that the Monascus pigments could be used to prepare AgNPs with potential antibacterial, antioxidant, and extraordinary catalytic activity. It can be used in biomedical applications, commercial food packaging, pathogen mitigation, and industrial waste water management.

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Section: Ft-ir Analysis Of Agnpsmentioning

confidence: 99%

Monascus pigment‐mediated green synthesis of silver nanoparticles: Catalytic, antioxidant, and antibacterial activity

Zhang

Guo

et al. 2021

Applied Organom Chemis

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“…From all the approaches of NPs synthesis, green synthesis approach is considered the most economic, sustainable, reliable and eco-friendly [ 37 ]. This approach of NPs synthesis does not require toxic chemicals, high temperature, high pressure and does not cause harm to human health and the environment [ 38 ]. At present, it is also considered a preferred method for NPs fabrication because of utilization of low-cost and non-hazardous raw material such as microorganisms fungi [ 39 ], algae [ 40 ], bacteria [ 41 ], plant extracts [ 42 ], natural polymers and proteins [ 43 ].…”

Section: Green Synthesized Metallic Nps: An Insightmentioning

confidence: 99%

A Systematic Review of Biosynthesized Metallic Nanoparticles as a Promising Anti-Cancer-Strategy

Andleeb

Asghar

et al. 2021

Cancers

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Cancer is one of the foremost causes of death worldwide. Cancer develops because of mutation in genes that regulate normal cell cycle and cell division, thereby resulting in uncontrolled division and proliferation of cells. Various drugs have been used to treat cancer thus far; however, conventional chemotherapeutic drugs have lower bioavailability, rapid renal clearance, unequal delivery, and severe side effects. In the recent years, nanotechnology has flourished rapidly and has a multitude of applications in the biomedical field. Bio-mediated nanoparticles (NPs) are cost effective, safe, and biocompatible and have got substantial attention from researchers around the globe. Due to their safe profile and fewer side effects, these nanoscale materials offer a promising cure for cancer. Currently, various metallic NPs have been designed to cure or diagnose cancer; among these, silver (Ag), gold (Au), zinc (Zn) and copper (Cu) are the leading anti-cancer NPs. The anticancer potential of these NPs is attributed to the production of reactive oxygen species (ROS) in cellular compartments that eventually leads to activation of autophagic, apoptotic and necrotic death pathways. In this review, we summarized the recent advancements in the biosynthesis of Ag, Au, Zn and Cu NPs with emphasis on their mechanism of action. Moreover, nanotoxicity, as well as the future prospects and opportunities of nano-therapeutics, are also highlighted.

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“…Effect of AgNPs against wide range of cancer cell lines was extensively reported. Death of cancer cells was caused by cytotoxic [120], anti-proliferative [41,117], anti-metastatic [121] and apoptotic [122] mechanisms. AgNPs of smaller sizes can freely penetrate into the cells through easy diffusion or pass through receptors, ion channels and transporters across the membrane.…”

Section: Anticancermentioning

confidence: 99%

A Review on Synthesis, Applications, Toxicity, Risk Assessment and Limitations of Plant Extracts Synthesized Silver Nanoparticles

Velidandi¹,

Dahariya²,

Pabbathi³

et al. 2020

NanoWorld

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In recent years, fabrication of AgNPs via plant extracts has gained much attention because of being environmentally friendly, non-hazardous and cost effective. The bio-fabrication of AgNPs using plant extracts as reducing, capping and stabilizing agents includes simpler, safer, less-toxic and energy efficient. AgNPs have been widely applied in numerous fields due to their bio-compatibility, multifunctionality, solubility, high stability, therapeutic and adhesive properties. This review focuses on the advantages of AgNPs synthesis using plant extracts and its applications in various fields for the betterment of mankind and environment with numerous examples and also highlights on explaining possible fundamental mechanisms involved in antimicrobial and anticancer activities of plant extract synthesized AgNPs.

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Assessment of antioxidant, antibacterial and anti-proliferative (lung cancer cell line A549) activities of green synthesized silver nanoparticles fromDerris trifoliata

Abstract: In this work, silver nanoparticles (AgNP-DTa) were prepared using an aqueous seed extract of D. trifoliata.

Cited by 70 publications

References 66 publications

Monascus pigment‐mediated green synthesis of silver nanoparticles: Catalytic, antioxidant, and antibacterial activity

Monascus pigment‐mediated green synthesis of silver nanoparticles: Catalytic, antioxidant, and antibacterial activity

A Systematic Review of Biosynthesized Metallic Nanoparticles as a Promising Anti-Cancer-Strategy

A Review on Synthesis, Applications, Toxicity, Risk Assessment and Limitations of Plant Extracts Synthesized Silver Nanoparticles

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