Assessment of antidiabetic potential of Cinnamomum tamala leaves extract in streptozotocin induced diabetic rats

Bisht, Sandeep; Sisodia, Siddhraj S.

doi:10.4103/0253-7613.84977

Cited by 22 publications

(7 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More so, the extract exhibited a significant increase in the percentage blood glucose level at 200 and 400 mg/kg of the aqueous and methanol extract when compared with the untreated controls. This is in line with the findings of Bisht and Sisoda (2011) that worked on the assessment of antidiabetic potential of Cinnamomum tamala leaves extract in streptozotocin-induced diabetic rats.…”

Section: Discussionsupporting

confidence: 91%

Anti-glycemic potential of Abelmoschus caillei (A. Chev.) Stevels Pod aqueous and methanol extract on streptozotocin-induced diabetic rats

Enoyoze¹,

Idu²,

Gabriel³

2022

jcbr

View full text Add to dashboard Cite

Diabetes mellitus is a lingering disease associated with pancreatic malfunctioning unable to synthesize sufficient insulin, or the insulin produced by the body cannot be effectively utilized, resulting in the accumulation of glucose in the body. This study evaluates the anti-diabetic activity of the aqueous and methanol extracts of Abelmoschus caillei in Streptozotocin-induced diabetic rats. Thirty male rats were administered with 45 mg/kg Streptozotocin (STZ) to induce-diabetes for 3 days and thereafter treated with graded oral doses of 200 and 400 mg/kg of aqueous and methanol pod extracts of A. caillei for 28 days. Hematological analysis, biochemical analysis and histopathology of the heart, were carried out using standard procedures. The results from this study showed a significant reduction in the elevated blood glucose levels at day 28 of the aqueous and methanol extracts (67.37; 130 mg/dL and 173.0; 140.0 mg/dL) with percentage reduction of (68.29; 56.3% and 30.7; 45.8%) respectively when compared with glibenclamide group and diabetes control (220.7 mg/dl; 43.98 % and 418.7 mg/dl; 0%). The hematological, lipid profile and liver function test had a slight significant difference specifically at 400 mg/kg of the extracts when compared with the control p> 0.05. The architectural frame work of the organ’s histopathology elicited no deformities in liver, kidney, pancreases, lungs, and heart the treated groups when compared with the diabetic control. This study showed that A. caillei extracts possess anti-diabetic potentials, thereby supporting the claims in the management of diabetes from the traditional folk’s report.

show abstract

Section: Discussionsupporting

confidence: 91%

Anti-glycemic potential of Abelmoschus caillei (A. Chev.) Stevels Pod aqueous and methanol extract on streptozotocin-induced diabetic rats

Enoyoze¹,

Idu²,

Gabriel³

2022

jcbr

View full text Add to dashboard Cite

show abstract

“…Only Bisht et al proposed that cinnamon extracts could protect pancreatic β-cells and improve insulin secretion, but no direct evidence was provided [19] . To further investigate the detailed mechanism, we studied the effect of the two extracts on pancreatic β-cells using pancreatic β-cell lines and primary cultured islets.…”

Section: Discussionmentioning

confidence: 99%

Trimer procyanidin oligomers contribute to the protective effects of cinnamon extracts on pancreatic β-cells in vitro

et al. 2016

View full text Add to dashboard Cite

Aim: Cinnamon extracts rich in procyanidin oligomers have shown to improve pancreatic β-cell function in diabetic db/db mice. The aim of this study was to identify the active compounds in extracts from two species of cinnamon responsible for the pancreatic β-cell protection in vitro. Methods: Cinnamon extracts were prepared from Cinnamomum tamala (CT-E) and Cinnamomum cassia (CC-E). Six compounds procyanidin B2 (cpd1), (-)-epicatechin (cpd2), cinnamtannin B1 (cpd3), procyanidin C1 (cpd4), parameritannin A1 (cpd5) and cinnamtannin D1 (cpd6) were isolated from the extracts. INS-1 pancreatic β-cells were exposed to palmitic acid (PA) or H 2 O 2 to induce lipotoxicity and oxidative stress. Cell viability and apoptosis as well as ROS levels were assessed. Glucose-stimulated insulin secretion was examined in PA-treated β-cells and murine islets. Results: CT-E, CC-E as well as the compounds, except cpd5, did not cause cytotoxicity in the β-cells up to the maximum dosage using in this experiment. CT-E and CC-E (12.5-50 μg/mL) dose-dependently increased cell viability in both PA-and H 2 O 2 -treated β-cells, and decreased ROS accumulation in H 2 O 2 -treated β-cells. CT-E caused more prominent β-cell protection than CC-E. Furthermore, CT-E (25 and 50 μg/mL) dose-dependently increased glucose-stimulated insulin secretion in PA-treated β-cells and murine islets, but CC-E had little effect. Among the 6 compounds, trimer procyanidins cpd3, cpd4 and cpd6 (12.5-50 μmol/L) dose-dependently increased the cell viability and decreased ROS accumulation in H 2 O 2 -treated β-cells. The trimer procyanidins also increased glucose-stimulated insulin secretion in PA-treated β-cells. Conclusion: Trimer procyanidins in the cinnamon extracts contribute to the pancreatic β-cell protection, thus to the anti-diabetic activity.

show abstract

“…The 95% ethanol extract of the leaves Cinnamomum Tamala shows the signi icant anti-diabetic action which has been proved through the streptozotocin induced diabetic rats at the concentration of 200mg/kg. To compare the anti-diabetic activity of the test drug, the reference drug glibenclamide at the dose of 500µg/kg is used (Bisht and Sisodia, 2011). Alloxan induced diabetic rat model is used to assess the anti-diabetic activity of the leaves extract Cinnamomum Tamala extract (water) at the dose of 250 mg/kg body wt./day.…”

Section: Cinnamomum Tamala (Patra)mentioning

confidence: 99%

Studying the Anti-Diabetic Basis of Ayurvedic Formulations –Avipattikara Churna And Triphala Churna

K¹,

Nagarajan²,

Kumar

2020

ijrps

View full text Add to dashboard Cite

Diabetes mellitus (DM), belongs to the class of metabolic diseases having the primary symptom associated with this disease is high sugar levels in the blood for an extended period. It can be categorized to the world's major diseases considering that affects the high population on the earth and presents two main types I and II.The prevalence of diabetes for all age-groups world-wide was estimated to be 2.8% in 2000 and 4.4% in 2030. Diabetes complications include possible blindness, amputation of a lower limb, renal failure, and cardiac arrest or stroke. There are twenty types of Pramehas (Kaphaja-10 Pittaja-6, and Vataja-4) have been mentioned in the Ayurveda. ‘Prameha’ and ‘Diabetes’ are synonymous. Diabetes is one of the ‘Prameha’ which consists of two words, ‘Pra’ meaning abundant, and ‘Meha' meaning 'passing of large quantity of Urine. Incidentally, the term diabetes has been derived from the Greek term 'Diabainein' to mean 'to cross through a siphon' meaning the continuous free flow of water and applied to mean the elimination of large quantity of Urine. Thus the terms ‘Prameha’ and ‘Diabetes’ carry similar meaning. This review summarizes the two Ayurvedic formulations for both types of DM, which are mentioned in the Ayurvedic Formulary of India. Till now, various kinds of synthetic and herbal formulations were made, and many are more frequently used to achieve desirable treatment. Patients prefer oral anti-diabetic medications since they are more comfortable to be administered, and for this reason, researchers focus their studies in this direction. This review aimed to explore the possibility of anti-diabetic treatment from herbal sources well mentioned in Ayurvedic Formulary of India that is Avipattikara Churna, Triphala Churna.Triphala Churna

show abstract

Assessment of antidiabetic potential of Cinnamomum tamala leaves extract in streptozotocin induced diabetic rats

Cited by 22 publications

References 10 publications

Anti-glycemic potential of Abelmoschus caillei (A. Chev.) Stevels Pod aqueous and methanol extract on streptozotocin-induced diabetic rats

Anti-glycemic potential of Abelmoschus caillei (A. Chev.) Stevels Pod aqueous and methanol extract on streptozotocin-induced diabetic rats

Trimer procyanidin oligomers contribute to the protective effects of cinnamon extracts on pancreatic β-cells in vitro

Studying the Anti-Diabetic Basis of Ayurvedic Formulations –Avipattikara Churna And Triphala Churna

Contact Info

Product

Resources

About