Comparative study of the antiulcer and antisecretory activity of Asparagus racemosus Willd (Shatawari) and Withania somnifera Dunal (Ashwagandha) root extract with a standard drug, ranitidine, in various models of gastric ulcer in rats is presented. Ulcer was induced by the indomethacin (NSAID) and swim (restraint) stress treatment. Results demonstrated that A. racemosus as well as W. somnifera methanolic extract (100 mg/kg BW/day p.o.) given orally for 15 days significantly reduced the ulcer index, volume of gastric secretion, free acidity, and total acidity. A significant increase in the total carbohydrate and total carbohydrate/protein ratio was also observed. Study also indicated an increase in antioxidant defense, that is, enzymes superoxide dismutase, catalase, and ascorbic acid, increased significantly, whereas a significant decrease in lipid peroxidation was observed. A. racemosus was more effective in reducing gastric ulcer in indomethacin-treated gastric ulcerative rats, whereas W. somnifera was effective in stress-induced gastric ulcer. Results obtained for both herbal drugs were comparable to those of the standard drug ranitidine.
AbstractBackgroundDiabetic wound are the major problem of society because of its delay healing of wound in hyperglycemia patient. The target of this study need to know the gallic acid compelling synergistically wound healing in diabetic animals as it is available in fruit extract or is more effective in given pure form in diabetic animals.MethodsThe wound healing effects of fruit extract Terminalia bellerica Roxb. and gallic acid were evaluated in experimentally induced hyperglycemic animals. In this investigation, excision and dead space wound models were used. The contraction wound %, re-epithelialization days, area of scar, histopathological examination of tissue, hydroxyproline level and weight of tissue granuloma were evaluated in this study.ResultsTerminalia bellerica fruit extract (400 mg/Kg) and gallic acid (200 mg/Kg) have been ingested by orally in streptozotocin induced diabetic rats. They were founded significantly (p<0.05) improved percentage wound contraction and decreased the size of scar area and days of re-epithelialization in excision wound model. Also, they were improved the level of hydroxyproline level in diabetic rats as compared to diabetic control group in dead space wound model. Standard drug vitamin C was also founded significantly improved wound healing activity in rats. These results suggested that treated groups accelerated wound healing activity in diabetic rat.ConclusionsThe observations and results obtained in the present study indicated the wound healing efficacy of fruit ethanolic extract and gallic acid in diabetic animals. Yet, the wound healing effect was increasingly reported with gallic acid.
Asparagus racemosus was found to be an effective antiulcerogenic agent, whose activity can well be compared with that of ranitidine hydrochloride. The results of this study suggest that Asparagus racemosus causes an inhibitory effect on release of gastric hydrochloric acid and protects gastric mucosal damage.
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