Assessment of anticholinesterase activities and antioxidant potentials of Anisomeles indica relevant to the treatment of Alzheimer’s disease

Uddin, Md. Josim; Abdullah-Al-Mamun, Md.; Biswas, Kamal Krishna; Asaduzzaman, Md.; Rahman, Md. Masudur

doi:10.1007/s13596-016-0224-z

Cited by 13 publications

(7 citation statements)

References 45 publications

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“…Therefore, treatment with antioxidant may reduce the oxidative stress and depressive disorder as well. Recently, we have reported that A. indica possesses anticholinesterase and antioxidative properties (Uddin et al, 2016 )which may substantiate the possible contribution to its antidepressant-like effect.…”

Section: Discussionmentioning

confidence: 85%

Antinociceptive and Anxiolytic and Sedative Effects of Methanol Extract of Anisomeles indica: An Experimental Assessment in Mice and Computer Aided Models

Uddin¹,

Reza²,

Abdullah-Al-Mamun³

et al. 2018

Front. Pharmacol.

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Anisomeles indica (L.) kuntze is widely used in folk medicine against various disorders including allergy, sores, inflammation, and fever. This research investigated the antinociceptive, anxiolytic and sedative effects of A. indica methanol extract. The antinociceptive activity was assessed with the acetic acid-induced writhing test and formalin-induced flicking test while sedative effects with open field and hole cross tests and anxiolytic effects with elevated plus maze (EPM) and thiopental-induced sleeping time tests were assayed. Computer aided (pass prediction, docking) analyses were undertaken to find out the best-fit phytoconstituent of total 14 isolated compounds of this plant for aforesaid effects. Acetic acid treated mice taking different concentrations of extract (50, 100, and 200 mg/kg, intraperitoneal) displayed reduced the writhing number. In the formalin-induced test, extract minimized the paw licking time of mice during the first phase and the second phase significantly. The open field and hole-cross tests were noticed with a dose-dependent reduction of locomotor activity. The EPM test demonstrated an increase of time spent percentage in open arms. Methanol extract potentiated the effect of thiopental-induced hypnosis in lesser extent comparing with Diazepam. The results may account for the use of A. indica as an alternative treatment of antinociception and neuropharmacological abnormalities with further intensive studies. The compound, 3,4-dihydroxybenzoic acid was found to be most effective in computer aided models.

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Section: Discussionmentioning

confidence: 85%

Antinociceptive and Anxiolytic and Sedative Effects of Methanol Extract of Anisomeles indica: An Experimental Assessment in Mice and Computer Aided Models

Uddin¹,

Reza²,

Abdullah-Al-Mamun³

et al. 2018

Front. Pharmacol.

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“…A number of factors have been identified; among them oxidative stress and cholinergic dysfunctions were found as the major contributor factors of AD [ 38 , 39 ]. In AD patients, the number of degrades time to time, so a neuroprotective approach also might be beneficial to this condition [ 40 - 42 ].…”

Section: Discussionmentioning

confidence: 99%

Assessment of in-vitro Cholinesterase Inhibitory and Thrombolytic Potential of bark and seed extracts of Tamarindus indica (L.) relevant to the treatment of Alzheimer's disease and clotting disorders

Biswas

Azad

Sultana

et al. 2017

J Intercult Ethnopharmacol

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Background:Low level of acetylcholine (ACh) is an important hallmark of Alzheimer’s disease (AD), a common type of progressive neurodegenerative disorder. Effective treatment strategies rely mostly on either enhancing the cholinergic function of the brain by improving the level of ACh from being a breakdown by cholinesterase enzymes. Again atherothrombosis is major life-threatening cerebral diseases. Traditionally Tamarindus indica (L.) has widely known for its medicinal values. Our aim is to investigate the cholinesterase inhibitory activities as well as thrombolytic activities of the bark and seeds crude methanolic extracts (CMEs) in the treatment of AD and clotting disorder.Materials and Methods:The crude methanol extract was prepared by cold extraction method and was assessed for acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activities by the Ellman’s method. For thrombolytic activity clot lysis method was applied.Results:To compare both the fractions, extracts from the bark got more AChE inhibitory activity than the seed with the inhibitory concentration 50% IC50 values of 268.09 and 287.15 µg/ml, respectively. The inhibitory activity of BuChE was quiet similar to that of AChE as IC50 values of both the fractions were 201.25 and 254.71 µg/ml. Again in-vitro thrombolytic activity of bark was 30.17% and of seed it was 22.53%.Conclusion:The results revealed that the CME of bark and seed both have moderate cholinesterases inhibitory activities as well as thrombolytic activities, worth of further investigations to identify the promising molecule(s) potentially useful in the treatment of AD as well as in clotting disorders.

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“…Several assays such as DPPH, hydroxyl radical scavenging activity, and lipid peroxidation assay were employed to evaluate the antioxidant potentials of G. pentaphylla because a single assay is insufficient to reflect the antioxidant property of a compound. The stable DPPH radical is a widely used method to evaluate the free radical scavenging ability of various samples [1,41]. The DPPH radical scavenging ability of the G. pentaphylla extracts revealed that scavenged DPPH radicals significantly in a dose dependent manner (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by gradual memory loss, cognitive deficit and behavioural aberration, and the most predominant cause of dementia in the elderly having age more than 65 years [1][2][3]. It has been estimated that around 35 million people are now afflicted by the AD, and currently it is the fourth leading cause of death in the elderly person [3,4] and it is inferred that it may be reached to 65.7 million by 2030 [2].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antioxidant, Cholinesterase Inhibitory Properties, and Antibacterial Potentials of Glycomis Pentaphylla Leaf Extract Relevant to the Treatment of Alzheimer's Disease

Rahman¹

2017

J App Pharm

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Assessment of anticholinesterase activities and antioxidant potentials of Anisomeles indica relevant to the treatment of Alzheimer’s disease

Cited by 13 publications

References 45 publications

Antinociceptive and Anxiolytic and Sedative Effects of Methanol Extract of Anisomeles indica: An Experimental Assessment in Mice and Computer Aided Models

Antinociceptive and Anxiolytic and Sedative Effects of Methanol Extract of Anisomeles indica: An Experimental Assessment in Mice and Computer Aided Models

Assessment of in-vitro Cholinesterase Inhibitory and Thrombolytic Potential of bark and seed extracts of Tamarindus indica (L.) relevant to the treatment of Alzheimer's disease and clotting disorders

Evaluation of Antioxidant, Cholinesterase Inhibitory Properties, and Antibacterial Potentials of Glycomis Pentaphylla Leaf Extract Relevant to the Treatment of Alzheimer's Disease

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