Evaluation of Antioxidant, Cholinesterase Inhibitory Properties, and Antibacterial Potentials of Glycomis Pentaphylla Leaf Extract Relevant to the Treatment of Alzheimer's Disease

Abstract

Evaluation of antioxidant, cholinesterase inhibitory properties, and antibacterial potentials of glycomis pentaphylla leaf extract relevant to the treatment of alzheimer's disease.

Phyto-Carbazole Alkaloids from the Rutaceae Family as Potential Protective Agents against Neurodegenerative Diseases

“…The methanolic extract of G. pentaphylla exhibited significant dual AChE (IC 50 325.1 ± 0.91 µg/mL) and butyryl cholinesterase (BChE) effects (IC 50 42.1 ± 3.30 µg/mL). Furthermore, the extract showed radical scavenging ability in 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay (IC 50 95.6 ± 0.68µg/mL) and a lipid peroxidation inhibitory effect (IC 50 288.7 ± 0.91 µg/mL) [85]. The total crude alkaloid extract of G. pentaphylla showed antioxidant potential in the DPPH assay (IC 50 966.93 µg/mL), ferric reducing antioxidant power (FRAP) (IC 50 510.81 µg/mL), 2,2 -azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay (IC 50 400.47 µg/mL), hydroxyl free radical (OH•) assay (IC 50 1805.28 µg/mL) and NO assay (IC 50 1426.50 µg/mL).…”