Antinociceptive and Anxiolytic and Sedative Effects of Methanol Extract of Anisomeles indica: An Experimental Assessment in Mice and Computer Aided Models

Uddin, Md. Josim; Reza, A. S. M. Ali; Abdullah-Al-Mamun, Md.; Kabir, Mohammad Shah Hafez; Nasrin, Shamima; Akhter, Sharmin; Arman, Mitra; Ma, Rahman

doi:10.3389/fphar.2018.00246

Cited by 46 publications

(58 citation statements)

References 53 publications

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“…The open field test (OFT) used to assess the locomotor and exploratory behavioral activity of mice/animals [33] and also useful in the evaluation of antidepressant like-behaviors [34]. Locomotion is considered as an index of alertness, whereas a decreased locomotion affects guide as central nervous system (CNS) depressant activity [35].…”

Section: Effect Of Methanol Extract Of P Calocarpa On Locomotor Actimentioning

confidence: 99%

Deciphering the Pharmacological Properties of Methanol Extract of Psychotria calocarpa Leaves by In Vivo, In Vitro and In Silico Approaches

et al. 2020

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The present study explores the neuropharmacological, antinociceptive, antidiarrheal, antioxidant, thrombolytic and cytotoxic activity of methanol extract of Psychotria calocarpa leaves (MEPC). In anxiolytic activity testing of MEPC by elevated plus maze test, hole–board test and light–dark test, the extract exhibited a dose-dependent reduction of anxiety while the open field test observed a decreased locomotion. The administration of MEPC revealed a significant dose-dependent reduction of depressant behavior in forced swimming and tail suspension test. Additionally, the antinociceptive and antidiarrheal activity exposed a significant reduction of nociception and diarrheal behavior at the highest dose. In addition, a strong antioxidant activity was observed in DPPH-free radical-scavenging assay (IC50 = 461.05 μg/mL), total phenol content (118.31 ± 1.12 mg) and total flavonoid content (100.85 ± 0.97 mg). The significant clot–lysis activity was also observed with moderate toxicity (LC50 = 247.92 μg/mL) level in the lethality assay of brine shrimp. Moreover, in silico molecular docking study showed that the compound Psychotriasine could offer promising active site interactions for binding proteins. Furthermore, ADME/T and toxicological properties of the compound satisfied the Lipinski’s rule of five and Veber rules for drug-like potential and toxicity level. Overall, MEPC had a potential neuropharmacological, antinociceptive, antidiarrheal and antioxidant activity that warranted further investigation.

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Section: Effect Of Methanol Extract Of P Calocarpa On Locomotor Actimentioning

confidence: 99%

Deciphering the Pharmacological Properties of Methanol Extract of Psychotria calocarpa Leaves by In Vivo, In Vitro and In Silico Approaches

et al. 2020

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“…structure activity relationship (SAR). The analyzed data were presented as Probable activity (Pa) and Probable inactivity (Pi) with the values in between 1.000 to 0.000 [28]. Compounds which exhibited higher Pa value than Pi (Pa > Pi) was considered as biological active and Pa>0.2 was regarded to have pharmacological potential.…”

Section: In Silico Studies Of Xanthonesmentioning

confidence: 99%

Xanthones protects lead-induced chronic kidney disease (CKD) via activating Nrf-2 and modulating NF-kB, MAPK pathway

Rana

Tangpong

Rahman

2020

Biochemistry and Biophysics Reports

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Xanthones from a tropical fruit of Garcinia mangostana L. is known to possess a wide spectrum of pharmacologic properties, including antioxidant, anti-bacterial, anti-inflammatory, and antidiabetic activities. The current study aimed to assess the possible protective effects of xanthones against lead acetate (PbAc)-induced chronic kidney disease (CKD). To accomplish, in vitro antioxidant assays of xanthones, in vivo oxidative stress parameters, histopathology, inflammatory parameters were evaluated using PbAc-induced IRC male mice. The study was supported by in silico molecular docking of respective organ receptor protein-ligand interaction. Results revealed that xanthones potentially scavenged the DPPH, superoxide, hydroxyl, and nitric oxide radicals. Oxidative stress, kidney dysfunction, inflammatory markers, and kidney apoptosis increased by PbAc were attenuated with the co-treatment of xanthones. The treatment remarkably improved the tissue architecture. Of note, in silico prediction of activity study showed that protective role of xanthones could be due to its efficacy to activate the Nrf-2, regulate the intracellular [Ca2+], as well as downregulate the NF-kB, MAPK pathway. In a nutshell, xanthones could be a potential candidate for the management of PbAc-induced kidney damage.

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“…The EPM test was used to explore the anxiolytic activity of the extract of A. trilobata in Swiss albino mice. The EPM apparatus consisted of two open arms (5 × 10 cm 2 ) and two closed arms (5 × 10 × l5 cm 3 ) with a mid-point (5 × 5 cm 2 ) [19,20]. Swiss albino mice of either sex were used in this study and the treatment was as described in the experimental design section.…”

Section: Anxiolytic Activity Elevated Plus Maze (Epm) Testmentioning

confidence: 99%

Possible neuropharmacological effects of Adenia trilobata (Roxb.) in the Swiss albino mice model

et al. 2020

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Background Known colloquially as akandaphal in Bangladesh, Adenia trilobata has some traditional uses. Its leaves and stems are extracted with pure methanol (MEATL, MEATS) and fractioned by n-hexane (NFATL, NFATS). The in vivo anxiolytic activity was evaluated by elevated plus maze (EPM) testing and hole-board test (HBT), whilst the locomotor activity was examined using the open-field test (OFT) and hole-cross test (HCT) and the antidepressant activity was assessed with the forced swimming test (FST) and the tail suspension test (TST). Results Regarding the anxiolytic activity, the 400-mg/kg doses of MEATL, NFATL, MEATS and NFATS exhibited maximum percentages of entry into the open arm of 33.85%, 32.23%, 30.06% and 41.84%, respectively, compare with the diazepam (69.33%). During HBT, MEATL (400 mg/kg) and NFATL (400 mg/kg) demonstrated 51.67 ± 0.88 and 57.67 ± 3.18 instances of head-dipping relative to diazepam (64.33 ± 3.16), whilst the locomotor activity showed a dose-dependent reduction in square movements and number of hole crossings. During FST and TST, the NFATL (400 mg/kg) exhibited rates of 43.32% and 57.71% time spent immobile, whilst fluoxetine experienced rates of 54.79% and 55.74%. Conclusion Adenia trilobata could be a potential component for the treatment of neuropharmacological defects. Further study is required.

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Antinociceptive and Anxiolytic and Sedative Effects of Methanol Extract of Anisomeles indica: An Experimental Assessment in Mice and Computer Aided Models

Cited by 46 publications

References 53 publications

Deciphering the Pharmacological Properties of Methanol Extract of Psychotria calocarpa Leaves by In Vivo, In Vitro and In Silico Approaches

Deciphering the Pharmacological Properties of Methanol Extract of Psychotria calocarpa Leaves by In Vivo, In Vitro and In Silico Approaches

Xanthones protects lead-induced chronic kidney disease (CKD) via activating Nrf-2 and modulating NF-kB, MAPK pathway

Possible neuropharmacological effects of Adenia trilobata (Roxb.) in the Swiss albino mice model

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