Assessing the toxic effects of hydroalcoholic extract of Stachys lavandulifolia Vahl on rat’s liver

Abstract

Aims: Stachys lavandulifoliaVahl is a frequently used plant to treat different diseases, but its probable toxic effects have not been reported yet. This study aimed to study the toxicity of the extract on rats' liver. Methods: In this experimental study, 100 rats were designated into 10 groups and injected normal saline or Stachys lavandulifolia Vahl extract at 50, 100, 150, and 200 mg/kg, intraperitoneally for 28 days. Four case groups and one control group were examined for ALT, AST and ALP after one month and the other groups were evaluated after two months. Results: In the fi rst month, the increase of ALP at all doses and the increase of AST at 200 mg/kg was significant, compared to the control group (p<0.05). In the second month, AST increased at the dosage of 150mg/ kg, and ALP decreased at the dosage of 100 mg/kg, compared to the control group (p<0.05). Histopathological assessment showed a signifi cant dose dependent increase both in necrotic-infl ammatory reactions and fi brotic lesions, in the fi rst and second months, compared to the control group (p<0.001). Conclusions: The Stachys lavandulifolia extract injected intraperitoneally has hepatotoxic effect, which is not eliminated by the drug withdrawal. Therefore, it is necessary to be consumed with caution (Tab. 4, Fig. 1

In vitro anti influenza virus activity, antioxidant potential and total phenolic content of twelve Iranian medicinal plants

“…These results showed that the radical scavenging activity of these plants extracts were higher than BHT. The antioxidant potential and phenolic diversity in many plants have been previously reported [30,31]. In present…”

Effect of Chitosan Incorporated with Cumin and Eucalyptus Essential Oils As Antimicrobial Agents on Fresh Chicken Meat

“…The toxicity of some of these compounds in in vivo situations might also be due to their pro-oxidant activities (Taghikhani et al 2013). However, in practice the prooxidant activity can be beneficial because by imposing a mild degree of oxidative stress, the levels of biotransformation enzymes and antioxidant defenses might increase, protecting the cells more efficiently (Bahmani et al 2014).…”

Onion (Allium Cepa) and Garlic (Allium Sativa L,) Oil effects on Blood Glucose Levels and Body Weight of Local Quails in Erbil Province

“…Heading toward further complications like type 2 diabetes mellitus, heart disease, and stroke (Nasri & Shirzad, 2013). The use of synthetic drugs to control obesity are varied but the usage of these drugs regarding their safety and efficacy are not promising (Taghikhani et al, 2012).…”