Assessing the potential biological activities of TiO₂ and Cu, Ni and Cr doped TiO₂ nanoparticles

Abstract

Nanoparticles bind to the surface of the cell membranes of microbes altering their basic cell functions and resulting in cell death.

[Retracted] CuO‐TiO2‐Chitosan‐Berbamine Nanocomposites Induce Apoptosis through the Mitochondrial Pathway with the Expression of P53, BAX, and BCL‐2 in the Human K562 Cancer Cell Line

“…These nanocomposites are commonly employed as nano delivery systems that improve bioavailability, biodistribution, and preferentially localizing diseased tissues while protecting healthy tissues. However, because of their chemical nature, many metal ion (TiO 2 /CuO) based nanoparticles also demonstrate effective antibacterial activity [ 30 , 31 ]. The antibacterial potential of a Berberis vulgaris plant extract against microorganisms linked with caries, such as Streptococcus spp.…”

Recent Updates on Multifunctional Nanomaterials as Antipathogens in Humans and Livestock: Classification, Application, Mode of Action, and Challenges

“…However, they can also interfere with essential cellular functions, leading to cell death and affecting cell division and protein synthesis. In a different study, Matras and colleagues [200] found Ag-NPs potent antifungal properties in in vitro experiments on F. avenaceum and F. equiseti by disrupting the cell membrane structure, hindering budding activity, and preventing cytotoxicity. Munir and his research group [201] found that titanium ions permeate cell membranes and bind with DNA, while Cu-, Cr-, and Ni-doped TiO2 binds to fungal cells, enhancing its antifungal activity.…”

“…In a different study, Matras and colleagues [199] found Ag-NPs potent antifungal properties in in vitro experiments on F. avenaceum and F. equiseti by disrupting the cell membrane structure, hindering budding activity, and preventing cytotoxicity. Munir and his research group [200] found that titanium ions permeate cell membranes and bind with DNA, while Cu-, Cr-, and Ni-doped TiO 2 binds to fungal cells, enhancing its antifungal activity. Accordingly, Morsy and colleagues [201] discovered that CuO-NPs significantly impact broiler chickens growth, immune status, DNA status, and histological structures, with dose-dependent increases in malondialdehyde levels, Cu contents, and the DNA fragmentation percent.…”