The relevance of the study of trade in the regions of Siberia and the Republic of Kyrgyzstan is due to the high, but poorly realized potential of their cooperation in the space of Central Asia. As well as the reversal of Russia’s geopolitical interests to the east. The purpose of the study is to analyze the potential and prospects for trade interaction between the Siberian Federal District (SFD) and Kyrgyzstan. The work is based on a scientific analysis of published results on the economic, social and foreign trade development of the Siberian Federal District and Kyrgyzstan. The paper provides an empirical analysis of trade based on regional customs data with the use of statistical packages and database analysis tools. The analysis was made for the period from 2010 to 2021. The dynamics presents the regional aspect of trade with Kyrgyzstan, considers the distribution of trade flows by counterparty countries and regions of Siberia, the commodity specialization of exports and imports of regions in the market of Kyrgyzstan. The study showed that despite the modest place of Kyrgyzstan in the trade of the SFD, there are opportunities for the growth of mutual cooperation, especially in the field of tourism, industrial cooperation and trade based on small and medium-sized businesses. Most regions of Siberia have untapped opportunities, and for some regions there is a need to realize the need for interaction. Тoday integration with Kyrgyzstan is one of the conditions for economic development, and an important solution to the issues of its economic security. The paper provides directions for improving cooperation and increasing mutual trade between the regions of the Siberian Federal District and Kyrgyzstan, taking into account internal and external factors of influence.