Assessing salivary biomarkers for analyzing orthodontic tooth movement

Umesan, Uday Kumar; Chua, Kui Lay; Krishnan, Vinod

doi:10.1016/j.ajodo.2013.02.006

Cited by 6 publications

(6 citation statements)

References 3 publications

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“…Moreover, the treatment outcome may require a long period of time before its effectiveness becomes visually noticeable . Salivary proteins have potential to provide a non‐invasive method to measure the effectiveness or adverse consequences of orthodontic treatment . Saliva is known to have contributions from salivary gland secretion, blood, gingival crevicular fluid (GCF), oral mucosa and the upper respiratory tract .…”

Section: Introductionmentioning

confidence: 99%

“…Orthodontic tooth movement is a result of resorption and apposition of the bone through forces applied to the periodontal ligaments (PDL). This movement can in theory have a measurable biochemical outcome, through proteins and metabolites that may appear before the clinical measures . Cytokines and inflammatory mediators have been proposed to be associated with orthodontic treatments .…”

Section: Introductionmentioning

confidence: 99%

“…2 Salivary proteins have potential to provide a non-invasive method to measure the effectiveness or adverse consequences of orthodontic treatment. 6 Saliva is known to have contributions from salivary gland secretion, blood, gingival crevicular fluid (GCF), oral mucosa and the upper respiratory tract. 7 Orthodontic tooth movement is a result of resorption and apposition of the bone through forces applied to the periodontal ligaments (PDL).…”

Section: Introductionmentioning

confidence: 99%

“…This movement can in theory have a measurable biochemical outcome, through proteins and metabolites that may appear before the clinical measures. 6,8 Cytokines and inflammatory mediators 9,10 have been proposed to be associated with orthodontic treatments. 11 However, to date there are no biomarkers universally accepted for measuring orthodontic tooth movement.…”

Section: Introductionmentioning

confidence: 99%

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Salivary protein biomarkers associated with orthodontic tooth movement: A systematic review

Allen

Edelmann

Abdulmajeed

et al. 2019

Orthod Craniofacial Res

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Structured Abstract Objective Saliva can provide a non‐invasive approach to indicate changes in the oral and systemic conditions. Salivary proteomics allows the discovery of new protein biomarkers associated with certain conditions. The effectiveness and physiological effects of orthodontic tooth movement in theory can be measured using salivary protein biomarkers. Setting and Sample Population This study applied a systematic review to analyse current literature to define and summarize salivary biomarkers associated with orthodontic tooth movement identified by mass spectrometry proteomics and other protein detection techniques. Materials and Methods Peer‐reviewed articles published through the 15th of November 2018 via the PubMed, EMBASE, Web of Science and Dentistry & Oral Sciences databases were reviewed. Only studies analysing protein biomarkers in saliva samples collected from human subjects associated with orthodontic treatments were included. Results Out of 482 articles, 7 studies were selected. Sample size ranged from 3 to 72 subjects. Minor variations of unstimulated whole saliva sample collection protocol were noted. Mass spectrometry proteomics and ELISA represented the majority of biomarker discovery and targeting, respectively. Twenty biomarkers were identified or chosen as target biomarkers. Conclusion Salivary proteins may be used to indicate effectiveness of orthodontic treatment and orthognathic treatment as well as adverse treatment consequence, such as root resorption.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Salivary protein biomarkers associated with orthodontic tooth movement: A systematic review

Allen

Edelmann

Abdulmajeed

et al. 2019

Orthod Craniofacial Res

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“…17 Levels of these inflammatory cytokines can be measured in various extracellular fluids such as gingival crevicular fluid (GCF) 18 and saliva. 19 Therefore, these can be considered as potential biomarkers of orthodontic tooth movement. Several potential biomarkers have been identified in various studies such as interleukin (IL)-1 beta, IL 8, IL 5, IL 6, and IL 2, tumor necrosis factor (TNF)-alpha, receptor activator of nuclear factor kappa-Β ligand (RANKL), Osteoprotegerin (OPG), and osteocalcin, which are associated with orthodontic tooth movement.…”

Section: Introductionmentioning

confidence: 99%

Impact of Vibration on the Levels of Biomarkers: A Systematic Review

Agrawal

2021

J Indian Orthod Soc

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Introduction: The objective of this systematic review is to assess the effect of vibrational force on biomarkers for orthodontic tooth movement. Methods: An electronic search was conducted for relevant studies (up to December 31, 2020) on the following databases: Pubmed, Google scholar, Web of Science, Cochrane Library, Wiley Library, and ProQuest Dissertation Abstracts and Thesis database. Hand searching of selected orthodontic journals was also undertaken. The selected studies were assessed for the risk of bias in Cochrane collaboration risk of bias tool. The “traffic plot” and “weighted plot” risk of bias distribution are designed in the RoB 2 tool. The 2 authors extracted the data and analyzed it. Results: Six studies fulfilled the inclusion criteria. The risks of biases were high for 4, low and some concern for other 2 studies. The biomarkers, medium, device, frequency and duration of device, as well as other data were extracted. The outcomes of the studies were found to be heterogenous. Conclusion: One study showed highly statistically significant levels of IL-1 beta with <.001. Rate of tooth movement was correlated with levels of released biomarkers under the influence of vibrational force in 3 studies, but it was found to be significant only in 1 study. It was further observed that vibration does not have any significant reduction in pain and discomfort.

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Controversies in tooth‐movement research

Krishnan¹,

Davidovitch

2015

Biological Mechanisms of Tooth Movement

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Assessing salivary biomarkers for analyzing orthodontic tooth movement

Cited by 6 publications

References 3 publications

Salivary protein biomarkers associated with orthodontic tooth movement: A systematic review

Salivary protein biomarkers associated with orthodontic tooth movement: A systematic review

Impact of Vibration on the Levels of Biomarkers: A Systematic Review

Controversies in tooth‐movement research

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