Assay of paracetamol by oxidation with peroxydisulphate

Helaleh, Murad I.H.; Korenaga, Takashi; Abu-Nameh, Eyad S. M.; Jamhour, R. M. A. Q.

doi:10.1016/s0031-6865(98)00032-6

Cited by 10 publications

(3 citation statements)

References 12 publications

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“…Literature survey reveals a great variety of methods for the estimation of this compound, including chromatography [3][4][5][6][7] , spectrophotometry [8][9][10][11][12][13] , fluorometry [14][15] , flow injection analysis 16,17 , atomic absorption 18 and electranalytical methods 19,20. The aim of the present study was to develop simple, sensitive and rapid methods for spectrophotometric determination of cephalexin based on its effect on the color fading reaction of N-bromosuccinimide (NBS) and p-anisidine in acetic acid medium. …”

Section: Introductionmentioning

confidence: 99%

Indirect Spectrophotometric Determination of

2013

Chem Sci Trans

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Simple, reliable and sensitive indirect spectrophotometric method was developed for the determination of cephalexin in pharmaceutical products without pretreatment. The method was based on the fading effect of the cephalexin on developed color product resulted from the bromination reaction of NBS with p-anisidine in acidic medium, subsequently vanished colored species was measured at 522 nm. Cephalexin acts in accordance with the Beer's law, under optimum conditions, at concentration ranges 1.5-10.0 µg/mL (R = 0.9949) with detection limit of 0.90 µg/mL. The relative standard deviation and error percent for 3 replicate determinations were found to be 2.2% and 1.75%, respectively. The proposed method was applied to the determination of cephalexin in different pharmaceutical products. A comparison of the method reported is made with standard official method and can be used as a convenient analysis method for routine quality control.

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Section: Introductionmentioning

confidence: 99%

Indirect Spectrophotometric Determination of

2013

Chem Sci Trans

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“…The extensive literature survey reveals several procedures of cefuroxime determination in medicines using liquid chromatography [12], capillary electrophoresis [8], polarography [2], and spectrofluorimetry [9]. A lot of spectrophotometric [4,5,11] and titrimetric [10,7] methods for quantitative determination of cefuroxime have been developed.…”

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confidence: 99%

Iodometric determination of cefuroxime by the potassium hydrogenperoxomonosulphate reaction

2016

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Simple methods for oxidimetric determination of antibiotic Cefuroxime in the substance and in the powder for solution for injection, which are based on the S-oxidation reaction by potassium hydrogenperoxomonosulphate in a weak acidic medium to S-oxide withThe aim of the study was to develop a new method for quantitative determination of cefuroxime in the substance and the powder for solution for injection by oxidimetry using potassium hydrogenperoxomonosulphate as an analytical reagent (KHSO 5 ). Materials and MethodsA triple potassium salt of Caro's acid, 2KHSO 5 •KHSO 4 • K 2 SO 4 (the trade name -"Oxon ® " manufactured by DuPont), was used as an oxidising agent. The active substance is potassium hydrogenperoxomonosulphate, KHSO 5 . The choice of the reagent was determined by its rather high oxidative activity, Е 0 = 1.84 V, availability, and satisfactory solubility in water.

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“…[11] Colored derivatives can simply be obtained by oxidation of paracetamol. Various oxidative reagents have been proposed, including Ce(IV), [12] iodylbenzene, [13] dichromate, [14] Fe(III) -2,4,6-tris(2-pyridyl)-S-triazine, [15] Fe(III)-1,10phenanthroline, [16,17] peroxydisulfate, [18] Cu(II)-neocuproine, [19] Fe(III)-K 3 Fe(CN) 6 . [20] Despite of the diversity of the cited variants, the proposed methods are generally of low sensitivity, require long reaction time or prolonged heating ( Table 1).…”

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Spectrophotometric Determination of Paracetamol by Reduction of 18-Molybdo-2-Phosphate Heteropoly Anion

Al-Shwaiyat¹

2013

JJC

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A very simple, rapid and sensitive spectrophotometric method for paracetamol assay in pharmaceuticals based on the reduction of 18-molybdo-2-phosphate heteropoly complex was developed. Reaction of 18-molybdo-2-phosphate with paracetamol is very fast at room temperature. The stoichiometry of the reaction is 1:1. The molar absorptivity calculated for paracetamol was equal to that for heteropoly blue formed in the studied reaction and was of 1.15×10 4 l mol-1 cm-1 at 820 nm. Beer`s law was followed for paracetamol concentrations from 0.3 to 7.5 µg ml-1 (l = 1 cm). The detection limit of the method was 0.03 µg ml-1 (l = 5 cm), and a relative standard deviation did not exceed 2.5 %. The method was successfully applied to the determination of paracetamol in pharmaceuticals.

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Assay of paracetamol by oxidation with peroxydisulphate

Cited by 10 publications

References 12 publications

Indirect Spectrophotometric Determination of

Indirect Spectrophotometric Determination of

Iodometric determination of cefuroxime by the potassium hydrogenperoxomonosulphate reaction

Spectrophotometric Determination of Paracetamol by Reduction of 18-Molybdo-2-Phosphate Heteropoly Anion

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