“…Using the developed method, we showed that MP was rapidly eliminated in plasma ( t 1/2 : 0.99 h) and that after its rapid absorption (Figure , Table ), negligible amounts were excreted in urine (Figure ). The renal excretion of MP seems to be the primary route of elimination following a single oral and intraperitoneal administration of MP to humans and SD male rats, respectively. On the other hand, the plasma concentrations of MPOL (the major metabolite), MP NOII and MPOL NOII increased rapidly after dosing (Figure ).…”