Aspirin attenuates the expression of adhesion molecules, risk of obesity, and adipose tissue inflammation in high-fat diet-induced obese mice

Roy, Sourav; Bhowmik, Dipty Rani; Begum, Rahima; Amin, Mohammad Tohidul; Islam, Aminul; Ahmed, Firoz; Hossain, Mohammad Salim

doi:10.1016/j.prostaglandins.2022.106664

Cited by 16 publications

(13 citation statements)

References 39 publications

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“…In this study, wealth index categorized into three variables where Richer and Richest converted to “Rich” and Poorer and Poorest to “Poor.” The interviewers transcribed the vaccination dates straight into the questionnaire if the cards were available. The respondents were asked to recollect the immunizations administered to their child if there was no vaccination card for the child or if a vaccine was not mentioned as administered in the vaccination card ( 8 , 31 , 35 , 50 – 52 ). Mother's/household head's occupation is categorized as agricultural/skilled worker (farming/agricultural work and semi-skilled labor/service), household/unskilled worker (unskilled labor, home-based manufacturing, domestic service, and other), and industrial worker (professional/technical, business, factory work or blue-collar service, poultry, or cattle raising).…”

Section: Methodsmentioning

confidence: 99%

Association of household fuel with acute respiratory infection (ARI) under-five years children in Bangladesh

Islam

Hasan

Ahammed

et al. 2022

Front. Public Health

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In developing countries, acute respiratory infections (ARIs) cause a significant number of deaths among children. According to Bangladesh Demographic and Health Survey (BDHS), about 25% of the deaths in children under-five years are caused by ARI in Bangladesh every year. Low-income families frequently rely on wood, coal, and animal excrement for cooking. However, it is unclear whether using alternative fuels offers a health benefit over solid fuels. To clear this doubt, we conducted a study to investigate the effects of fuel usage on ARI in children. In this study, we used the latest BDHS 2017–18 survey data collected by the Government of Bangladesh (GoB) and estimated the effects of fuel use on ARI by constructing multivariable logistic regression models. From the analysis, we found that the crude (the only type of fuel in the model) odds ratio (OR) for ARI is 1.69 [95% confidence interval (CI): 1.06–2.71]. This suggests that children in families using contaminated fuels are 69.3% more likely to experience an ARI episode than children in households using clean fuels. After adjusting for cooking fuel, type of roof material, child's age (months), and sex of the child–the effect of solid fuels is similar to the adjusted odds ratio (AOR) for ARI (OR: 1.69, 95% CI: 1.05–2.72). This implies that an ARI occurrence is 69.2% more likely when compared to the effect of clean fuel. This study found a statistically significant association between solid fuel consumption and the occurrence of ARI in children in households. The correlation between indoor air pollution and clinical parameters of ARI requires further investigation. Our findings will also help other researchers and policymakers to take comprehensive actions by considering fuel type as a risk factor as well as taking proper steps to solve this issue.

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Section: Methodsmentioning

confidence: 99%

Association of household fuel with acute respiratory infection (ARI) under-five years children in Bangladesh

Islam

Hasan

Ahammed

et al. 2022

Front. Public Health

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“…The present data-based study examines the global association between meteorological factors and Monkeypox cases. Various vector-borne zoonotic viral diseases including COVID-19, dengue, Chikungunia, malaria, Ebola, and Zika are increasing with changes in climatic conditions [ 31 , 32 , 33 , 34 , 35 ]. Previous studies have shown that meteorological factors affect the growth and activity of respiratory viral diseases including SARS-CoV [ 36 , 37 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

Association between Global Monkeypox Cases and Meteorological Factors

Islam

Sangkham

Tiwari

et al. 2022

IJERPH

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The emergence of an outbreak of Monkeypox disease (MPXD) is caused by a contagious zoonotic Monkeypox virus (MPXV) that has spread globally. Yet, there is no study investigating the effect of climatic changes on MPXV transmission. Thus, studies on the changing epidemiology, evolving nature of the virus, and ecological niche are highly paramount. Determination of the role of potential meteorological drivers including temperature, precipitation, relative humidity, dew point, wind speed, and surface pressure is beneficial to understand the MPXD outbreak. This study examines the changes in MPXV cases over time while assessing the meteorological characteristics that could impact these disparities from the onset of the global outbreak. To conduct this data-based research, several well-accepted statistical techniques including Simple Exponential Smoothing (SES), Auto-Regressive Integrated Moving Average (ARIMA), Automatic forecasting time-series model (Prophet), and Autoregressive Integrated Moving Average with Explanatory Variables (ARIMAX) were applied to delineate the correlation of the meteorological factors on global daily Monkeypox cases. Data on MPXV cases including affected countries spanning from May 6, 2022, to November 9, 2022, from global databases and meteorological data were used to evaluate the developed models. According to the ARIMAX model, the results showed that temperature, relative humidity, and surface pressure have a positive impact [(51.56, 95% confidence interval (CI): −274.55 to 377.68), (17.32, 95% CI: −83.71 to 118.35) and (23.42, 95% CI: −9.90 to 56.75), respectively] on MPXV cases. In addition, dew/frost point, precipitation, and wind speed show a significant negative impact on MPXD cases. The Prophet model showed a significant correlation with rising MPXD cases, although the trend predicts peak values while the overall trend increases. This underscores the importance of immediate and appropriate preventive measures (timely preparedness and proactive control strategies) with utmost priority against MPXD including awareness-raising programs, the discovery, and formulation of effective vaccine candidate(s), prophylaxis and therapeutic regimes, and management strategies.

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“…For example, the administration of GW311616A, an inhibitor of neutrophil elastase, significantly attenuates vascular leakage, leukocyte infiltration, and the expression of proinflammatory cytokines in the white adipose tissues (WAT) in diet-induced obese mice [ 59 ]. The expression of adhesion molecules, such as intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1), is associated with the expression of adipogenesis and inflammation markers such as IL-6 and TNF-α [ 60 ].…”

Section: Molecular Targets For Obesity Treatmentmentioning

confidence: 99%

The Related Metabolic Diseases and Treatments of Obesity

2022

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Obesity is a chronic disease characterized by the abnormal or excessive accumulation of body fat, affecting more than 1 billion people worldwide. Obesity is commonly associated with other metabolic disorders, such as type 2 diabetes, non-alcoholic fatty liver disease, cardiovascular diseases, chronic kidney disease, and cancers. Factors such as a sedentary lifestyle, overnutrition, socioeconomic status, and other environmental and genetic conditions can cause obesity. Many molecules and signaling pathways are involved in the pathogenesis of obesity, such as nuclear factor (NF)-κB, Toll-like receptors (TLRs), adhesion molecules, G protein-coupled receptors (GPCRs), programmed cell death 1 (PD-1)/programmed death-ligand 1 (PD-L1), and sirtuin 1 (SIRT1). Commonly used strategies of obesity management and treatment include exercise and dietary change or restriction for the early stage of obesity, bariatric surgery for server obesity, and Food and Drug Administration (FDA)-approved medicines such as semaglutide and liraglutide that can be used as monotherapy or as a synergistic treatment. In addition, psychological management, especially for patients with obesity and distress, is a good option. Gut microbiota plays an important role in obesity and its comorbidities, and gut microbial reprogramming by fecal microbiota transplantation (FMT), probiotics, prebiotics, or synbiotics shows promising potential in obesity and metabolic syndrome. Many clinical trials are ongoing to evaluate the therapeutic effects of different treatments. Currently, prevention and early treatment of obesity are the best options to prevent its progression to many comorbidities.

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Aspirin attenuates the expression of adhesion molecules, risk of obesity, and adipose tissue inflammation in high-fat diet-induced obese mice

Cited by 16 publications

References 39 publications

Association of household fuel with acute respiratory infection (ARI) under-five years children in Bangladesh

Association of household fuel with acute respiratory infection (ARI) under-five years children in Bangladesh

Association between Global Monkeypox Cases and Meteorological Factors

The Related Metabolic Diseases and Treatments of Obesity

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