The Related Metabolic Diseases and Treatments of Obesity

Yang, Ming; Liu, Shuai; Zhang, Chunye

doi:10.3390/healthcare10091616

Cited by 34 publications

(24 citation statements)

References 162 publications

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“…A clinical study showed that PDAC patients with systemic inflammation characterized by a neutro-phil/lymphocyte ratio > 3.1 have a lower median overall survival compared to patients with a neutrophil/lymphocyte ratio < 3.1 in response to the treatment of anti-CD40 monoclonal antibody in combination with gemcitabine[ 19 ]. Obesity can induce systemic inflammation and contribute to cancer progression, including PDAC[ 20 ]. The chronic low-grade inflammation in white adipose tissues of obese patients plays an important role in PDAC progression[ 21 ].…”

Section: Pathogenesis Of Pancreatic Cancer and Relative Molecular Mec...mentioning

confidence: 99%

Clinical diagnosis and management of pancreatic cancer: Markers, molecular mechanisms, and treatment options

Zhang¹,

Liu²,

Yang³

2022

World J Gastroenterol

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Pancreatic cancer (PC) is the third-leading cause of cancer deaths. The overall 5-year survival rate of PC is 9%, and this rate for metastatic PC is below 3%. However, the PC-induced death cases will increase about 2-fold by 2060. Many factors such as genetic and environmental factors and metabolic diseases can drive PC development and progression. The most common type of PC in the clinic is pancreatic ductal adenocarcinoma, comprising approximately 90% of PC cases. Multiple pathogenic processes including but not limited to inflammation, fibrosis, angiogenesis, epithelial-mesenchymal transition, and proliferation of cancer stem cells are involved in the initiation and progression of PC. Early diagnosis is essential for curable therapy, for which a combined panel of serum markers is very helpful. Although some mono or combined therapies have been approved by the United States Food and Drug Administration for PC treatment, current therapies have not shown promising outcomes. Fortunately, the development of novel immunotherapies, such as oncolytic viruses-mediated treatments and chimeric antigen receptor-T cells, combined with therapies such as neoadjuvant therapy plus surgery, and advanced delivery systems of immunotherapy will improve therapeutic outcomes and combat drug resistance in PC patients. Herein, the pathogenesis, molecular signaling pathways, diagnostic markers, prognosis, and potential treatments in completed, ongoing, and recruiting clinical trials for PC were reviewed.

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Section: Pathogenesis Of Pancreatic Cancer and Relative Molecular Mec...mentioning

confidence: 99%

Clinical diagnosis and management of pancreatic cancer: Markers, molecular mechanisms, and treatment options

Zhang¹,

Liu²,

Yang³

2022

World J Gastroenterol

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“…Obesity is a global health problem and is a chronic disease characterized by the excessive accumulation of body fat. Exercise, diets (carbohydrate-restricted diets, carbohydrate-reduced high-protein diets, low-fat diets, fiber-rich Mediterranean diets), bariatric surgery, medicines, and micro-RNA-based treatments are clinical strategies to prevent and treat obesity [ 12 ]. Besides the above-mentioned strategies, maintaining healthy gut microbiota and psychological management also influence the obese condition [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…Exercise, diets (carbohydrate-restricted diets, carbohydrate-reduced high-protein diets, low-fat diets, fiber-rich Mediterranean diets), bariatric surgery, medicines, and micro-RNA-based treatments are clinical strategies to prevent and treat obesity [ 12 ]. Besides the above-mentioned strategies, maintaining healthy gut microbiota and psychological management also influence the obese condition [ 12 ]. Phenolic compounds also play an important role in regulating obesity and gut microbiota [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Composition, Microbiota, Mechanisms, and Anti-Obesity Properties of Rice Bran

Sivamaruthi

Alagarsamy²,

Thangaleela

et al. 2023

Foods

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Rice is a major cereal crop and a staple food for nearly 50% of people worldwide. Rice bran (RB) is a nutrient-rich by-product of rice processing. RB is rich in carbohydrates, fibers, proteins, lipids, minerals, and several trace elements (phosphorus, calcium, magnesium, potassium, and manganese). The extraction process and storage have influenced RB extracts and RB oil’s quality. The RB composition has also varied on the rice cultivars. The color of RB indicates the richness of the bioactive compounds, especially anthocyanins. γ-oryzanol, tocopherols, tocotrienols, and unsaturated fatty acids are major components of RB oil. It has been established that RB supplementation could improve the host’s health status. Several preclinical and clinical studies have reported that RB has antioxidant, anticancer, anti-inflammatory, anticolitis, and antidiabetic properties. The beneficial biological properties of RB are partially attributed to its ability to alter the host microbiome and help to maintain and restore eubiosis. Non-communicable diseases (NCDs), including heart disease, diabetes, cancer, and lung disease, account for 74% of deaths worldwide. Obesity is a global health problem and is a major reason for the development of NCDs. The medical procedures for managing obesity are expensive and long-term health supplements are required to maintain a healthy weight. Thus, cost-effective natural adjuvant therapeutic strategy is crucial to treat and manage obesity. Several studies have revealed that RB could be a complementary pharmacological candidate to treat obesity. A comprehensive document with basic information and recent scientific results on the anti-obesity activity of RB and RB compounds is obligatory. Thus, the current manuscript was prepared to summarize the composition of RB and the influence of RB on the host microbiome, possible mechanisms, and preclinical and clinical studies on the anti-obesity properties of RB. This study suggested that the consumption of RB oil and dietary RB extracts might assist in managing obesity-associated health consequences. Further, extended clinical studies in several ethnic groups are required to develop dietary RB-based functional and nutritional supplements, which could serve as an adjuvant therapeutic strategy to treat obesity.

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“…Similarly, the International Diabetes Foundation (IDF) reported that prevalence of diabetes in 2019 was 463 million, and this is expected to increase further and reach 700 million by 2045 [ 3 ]. Apart from type 2 diabetes mellitus (T2DM), obesity has been associated with many other metabolic disorders, such as cardiovascular diseases (CVDs), non-alcoholic fatty liver disease (NAFLD), several types of cancers and, recently, it was linked with COVID-19 mortality [ 4 ]. Although body weight is influenced by both genetic and environmental factors, the increased prevalence of adiposity globally suggests that urbanization, followed by food marketing and access to refined and energy-dense food items, along with reduced physical activity, are the main drivers of obesity [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Dietary Patterns, Cardiometabolic and Lifestyle Variables in Greeks with Obesity and Metabolic Disorders

et al. 2022

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There is considerable evidence that some dietary patterns contribute to obesity and metabolic disorders but there is less data on diet’s association with different health parameters. We investigated the interaction between different dietary patterns and anthropometric, biochemical, lifestyle, and psychological health parameters in a Greek population with obesity and metabolic disorders. To the best of our knowledge, this is the first study in Greece with a thorough and holistic approach in analyzing such relationships. For assessing food patterns, revealing underlying structures, and reducing the number of variables we applied exploratory factor analysis (EFA). Principal Component Analysis was chosen as the extraction method using Varimax rotation, and three regression sets were computed. The study involved 146 Greek metabolically unhealthy obese adults, both men and women. Our cohort was categorized into four dietary patterns: “Western type diet”, “Mediterranean-like diet”, “Healthy diet”, and “Animal meat and sauces diet”. Dietary patterns characterized by a high consumption of energy-dense and animal-derived foods were positively associated with anthropometric and biochemical parameters related to metabolic disorders. Plant-based, healthier dietary patterns, on the other hand, were associated with better biochemical and mental health profiles among metabolically unhealthy obese individuals.

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The Related Metabolic Diseases and Treatments of Obesity

Cited by 34 publications

References 162 publications

Clinical diagnosis and management of pancreatic cancer: Markers, molecular mechanisms, and treatment options

Clinical diagnosis and management of pancreatic cancer: Markers, molecular mechanisms, and treatment options

Composition, Microbiota, Mechanisms, and Anti-Obesity Properties of Rice Bran

Dietary Patterns, Cardiometabolic and Lifestyle Variables in Greeks with Obesity and Metabolic Disorders

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