Aspergillus flavus Wound Infection Following Repair of a Ruptured Duodenum in a Non-immunocompromised Host

Sawyer, Robert G.; Schenk, Worthington G.; Adams, Reid B.; Pruett, Timothy L.

doi:10.3109/00365549209062469

Cited by 8 publications

(2 citation statements)

References 13 publications

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“…For patients with post‐operative wound infection caused by Aspergillus spp., the interval between surgery and infection is measured in days, rather than the months required for endocarditis [5,87,129–143] In addition, many patients with wound aspergillosis were immunosuppressed, with half of the cases occurring in solid‐organ transplant recipients. As this condition can progress to profound or disseminated infection, all patients need to be treated aggressively with combined medical and surgical therapy.…”

Section: Literature Reviewmentioning

confidence: 99%

Post-operative aspergillosis

Pasqualotto

Denning

2006

Clinical Microbiology and Infection

157

173

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While invasive aspergillosis occurs typically in severely immunocompromised patients, cases of surgical site infection have been reported in immunocompetent individuals. The Medline, LILACS and EMBASE databases were searched for descriptions of cases of post-operative aspergillosis, and references from relevant articles and conference abstracts were reviewed. More than 500 cases of post-operative aspergillosis were found. Cardiac surgery (n = 188), ophthalmological surgery (n > 90) and dental surgery (n > 100) were associated with the majority of cases. Other cases involved wound infections (n = 22), bronchial infections (n = 30), mediastinitis (n = 11), pleural aspergillosis (n = 1), infections following orthopaedic surgery (n = 42), vascular prosthetic surgery (n = 22), breast surgery (n = 5), abdominal surgery (n = 10) and neurosurgery (n = 25). In most patients, the source was presumed to be airborne infection during the surgical procedure. Prevention of these infections requires special care of the ventilation system in the operating room. Successful treatment requires rapid diagnosis, surgical debridement and antifungal therapy, often with voriconazole. In order to improve the outcome, better diagnostic methods are needed, particularly for cases of endocarditis and aortitis.

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Section: Literature Reviewmentioning

confidence: 99%

Post-operative aspergillosis

Pasqualotto

Denning

2006

Clinical Microbiology and Infection

157

173

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“…The number of PCA cases in immunocompetent individuals was rather low in those articles. Nine cases of post-traumatic or post-operative PCA in immunocompetent individuals were compiled from eight articles in the literature and are presented in Table 1 [8][9][10][11][12][13][14][15]. One of these was a cutaneous aspergillosis case caused by A. terreus in a seven-year-old child reported from Turkey and another was a 70-year-old male patient with A. flavus and C. guilliermondii infection [11,12].…”

Section: Discussionmentioning

confidence: 99%

Primary Cutaneous Aspergillosis in Immunocompetent Adults: Three Cases and a Review of the Literature

Avkan-Oğuz

Çelik

Satoğlu

et al. 2020

Cureus

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Primary cutaneous aspergillosis (PCA) can rarely affect immunocompetent people. There is limited knowledge about the prevalence, diagnosis and management of the disease because there are only case reports or small case series in the literature. For this reason, the diagnosis and treatment of three immunocompetent adult patients diagnosed with PCA were discussed by reviewing the literature. In the current report, in addition to treatment with voriconazole for 8-12 weeks we performed repeated surgical debridement for the treatment of these cases. After two negative tissue cultures, the wounds were either successfully closed primarily or reconstructed using a skin graft. Management of PCA cases will become easier as more reports and further studies of PCA contribute to our shared knowledge. Currently, the most appropriate management approach is to make individualized treatment decisions according to the patients' clinical features and treatment response which includes several surgical debridement as well as antifungal therapy.

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Aspergillosis in Surgical Patients

Pasqualotto

2009

Aspergillosis: From Diagnosis to Prevention

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Most physicians will promptly consider the possibility of invasive aspergillosis in high-risk patients in the presence of an appropriate clinical syndrome. Aspergillosis will however only rarely be listed amongst the possible aetiologies of surgical site infections, although hundreds of cases have been published so far. This chapter reviews the current literature on post-operative aspergillosis. A few illustrative clinical cases are also shown. In most patients, the source was presumed to be airborne infection during the surgical procedure. Diagnosis relies on a high index of suspicion and treatment usually requires a combination of medical and surgical interventions. Prevention of post-operative aspergillosis requires special care with the ventilation system in the operating room.

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Aspergillus flavus Wound Infection Following Repair of a Ruptured Duodenum in a Non-immunocompromised Host

Cited by 8 publications

References 13 publications

Post-operative aspergillosis

Post-operative aspergillosis

Primary Cutaneous Aspergillosis in Immunocompetent Adults: Three Cases and a Review of the Literature

Aspergillosis in Surgical Patients

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