Primary Cutaneous Aspergillosis in Immunocompetent Adults: Three Cases and a Review of the Literature

Avkan-Oğuz, Vildan; Çelik, Muammer; Satoğlu, İsmail Safa; Ergon, Mahmut Cem; Acan, Ahmet Emrah

doi:10.7759/cureus.6600

Cited by 9 publications

(8 citation statements)

References 17 publications

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“…A similar growth of Aspergillus spps. has been noted in immunocompetent patients in the studies of Tahir et al, Camus et al, Avkan-Oğuz et al, and Neki et al 2 8 9 10…”

Section: Discussionmentioning

confidence: 82%

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Primary Cutaneous Aspergillosis in an Immunocompetent Patient: A Case Report from a Tertiary Care Hospital in Chennai

et al. 2022

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Aspergillosis is a systemic fungal infection that commonly affects immunocompromised individuals and, less frequently, immunocompetent individuals. It is the most common opportunistic fungal disease after candidiasis. This is primarily a pulmonary infection and can also involve other body sites like paranasal sinuses and cutaneous tissues. Aspergillus fumigatus, Aspergillus niger, and Aspergillus flavus are the common species infecting humans. Primary cutaneous aspergillosis (PCA) is usually caused by A. flavus and A. fumigatus. It is commonly seen in immunocompromised patients such as those suffering from diabetes, malignancies, tuberculosis, human immunodeficiency virus, or patients on long-term steroids and antibiotics. In this article, we report a case of PCA, in the immediate postoperative period, following a road traffic accident, in an immunocompetent patient. This posed a diagnostic challenge to the treating physicians. A. flavus was confirmed with 10% potassium hydroxide mount, lactophenol cotton blue, and growth on Sabouraud dextrose agar from tissue culture sample. Antifungal treatment was initiated with oral itraconazole 200 mg after performing antifungal susceptibility testing based on Clinical and Laboratory Standards Institute guidelines. The patient's condition improved and was discharged. Thus, early detection of PCA combined with medical and surgical intervention can successfully eradicate infection and help in preventing disseminated aspergillosis.

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“…A similar growth of Aspergillus spps. has been noted in immunocompetent patients in the studies of Tahir et al, Camus et al, Avkan-Oğuz et al, and Neki et al 2 8 9 10…”

Section: Discussionmentioning

confidence: 82%

“…Light green velvety colonies of A. flavus was isolated in culture (►Figs. 5,6,7,8,9). LPCB mount demonstrated conidiophores of variable length, rough, pitted and spiny along with biseriate phialides covering the entire vesicle and pointing out in all directions (►Figs.…”

Section: Case Reportmentioning

confidence: 99%

Primary Cutaneous Aspergillosis in an Immunocompetent Patient: A Case Report from a Tertiary Care Hospital in Chennai

et al. 2022

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“…After effective surgical debridement and systemic antifungal treatment reduces the chances of recurrence of infection [19].…”

Section: Discussionmentioning

confidence: 99%

Cutaneous aspergillosis in an immunocompetent patient: a case report

Bagate

Birare

Jadhav

et al. 2020

Trop J Pathol Microbiol

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Cutaneous aspergillosis is a rare disease that is usually seen in immunosuppressed patients. It is rarely found in immunocompetent patients and it is mostly caused by Aspergillus. flavus, Aspergillus fumigatus, and rarely by Aspergillus niger. Cutaneous Aspergillosis is of two types: primary or secondary. Primary cutaneous aspergillosis frequently involves sites of skin injury, at or near intravenous catheter sites, at sites associated with occlusive dressings, at sites of traumatic inoculation, surgery or burns. Secondary cutaneous lesions occur as a result of either from widespread blood-borne seeding of the skin or it may occur from contiguous extension to the skin from an infected underlying structure. The current study is presenting a case of a 25-year-old female, a farmer by occupation, presented with multiple scaly plaques and verrucous nodules with a past history of trauma over knee 3 years back. After trauma she initially noticed lesions over knee followed by the elbow, face and oral lesions noticed 7 months back. There was no present or past history of weight loss, anorexia and serological tests were negative for HIV. One year back she was diagnosed as lupus vulgaris and received Anti-Tubercular treatment without much benefit. She came to our hospital where biopsy from lesions over elbow revealed dense inflammatory exudate, septate fungal hyphae showing acute angle branching on H and E stain and PAS stain, which is suggestive of aspergillosis. Scrapping from oral lesion also revealed inflammatory cells with septate fungal hyphae with acute angle branching on PAP stain. Histopathological, cytological study and fungal culture show fungal infection caused by Aspergillus niger. In cutaneous aspergillosis, surgical excision alone or combination with drug therapy was found to be curative. The present case report was important due to its rarity.

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“…This is generally caused by a variety of Aspergillus species including A. flavus, A. fumigatus, A. niger and A. terreus(Van Burik et el. 1998 and Avkan et al2020) [9,21].Approximately, 35% of all cases of onichomycosis are due to the infection of Aspergillus. A flavus, A. niger and A. terreus have been the most common etiological agents reported for onichomycosis in human (Bongomin et al2018) [12].…”

Section: Allergic Aspergillosis Including Abpa Sinus and Ear Canal In...mentioning

confidence: 99%

“…The patients might also coughed up blood in sputum. Depending upon the severity of infections, the disease is broadly categorized as allergic, chronic and invasive aspergillosis grouped as under: [9,12,21] RESISTANT ASPERGILLOSIS (Shelders et al 2012, Helene et al 2020 [22,23] CORONAVIRUS COMPLICATING ASPERGILLOSIS (Kieren et al 2021) [24] The infection caused by the Aspergillus initially developed the inflammation in lungs and sinuses causing ABPA and sinusitis respectively. In fact, both the conditions might be treated as the happenings prior to infection (Glass and Amedee 2011 and Agarwal et al 2013) [11,17].…”

Section: Types Of Aspergillosismentioning

confidence: 99%

Aspergillosis: The Disease at a Glance. Review Article

Salim¹,

Masroor²,

Parween³

2023

ArveMED

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Aspergillosis is mainly a lung infection in human. This is caused by the fungus Aspergillus. Though, most of the strains are harmless to humans, only a few of them can cause serious diseases mostly in immunocompromised individuals. The individuals with a medical history of respiratory problems are at high risk of infection. An aspergillosis patient if not treated well within time it may result in invasive aspergillosis developing lung fibrosis, huge hemoptysis and multiple organ failures, CNS and brain infections, endocarditis and death. The present paper deals with their disease causing abilities, diagnosis and treatment in human in the light of recent researches done so far in the field of medical microbiology and pathology.

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Primary Cutaneous Aspergillosis in Immunocompetent Adults: Three Cases and a Review of the Literature

Cited by 9 publications

References 17 publications

Primary Cutaneous Aspergillosis in an Immunocompetent Patient: A Case Report from a Tertiary Care Hospital in Chennai

Primary Cutaneous Aspergillosis in an Immunocompetent Patient: A Case Report from a Tertiary Care Hospital in Chennai

Cutaneous aspergillosis in an immunocompetent patient: a case report

Aspergillosis: The Disease at a Glance. Review Article

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