Aspergillosis of the nose and paranasal sinuses

Jahrsdoerfer, Robert A.; Ejercito, Victor S.; Johns, Michael M.; Cantrell, Robert W.; Sydnor, J B

doi:10.1016/s0196-0709(79)80003-4

Cited by 188 publications

(55 citation statements)

References 44 publications

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“…Meanwhile, orbital apex syndrome used to be regarded as a classic manifestation of CIFRS that usually affects immunocompromised patients. Orbital apex syndrome is characterized by decreased vision and ocular immobility resulting from a mass in the superior portion of an orbit [28–30]. Though the prevalence of orbital apex syndrome of CIFRS (24/44, 54.5%) was higher than that of GIFRS (5/11, 45.5%), our study has not found a significant difference ( P = .739).…”

Section: Discussioncontrasting

confidence: 64%

Entities of Chronic and Granulomatous Invasive Fungal Rhinosinusitis: Separate or Not?

Zhou

Wang

et al. 2018

Open Forum Infectious Diseases

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BackgroundChronic and granulomatous invasive fungal rhinosinusitis are important causes of blindness and craniocerebral complications. However, the classification of these 2 diseases remains controversial.MethodsWe retrospectively analyzed patients with chronic and granulomatous invasive fungal rhinosinusitus in a Chinese tertiary hospital from 2009 to 2017, with a focus on classification and comparisons.ResultsAmong 55 patients enrolled in our study, 11 (11/55, 20%) had granulomatous invasive fungal rhinosinusitis (GIFRS) and 44 (44/55, 80%) had chronic invasive fungal rhinosinusitis (CIFRS). Aspergillus fumigatus and Dematiaceous hyphomycetes were identified in 2 patients with GIFRS. Compared with granulomatous type, CIFRS was more frequently encountered in immunocompromised patients (P = .022), and the time from onset to diagnosis was much shorter (P = .001). Proptosis and orbital apex syndrome showed no significant difference between granulomatous and CIFRS in our study. The treatment options and prognosis of both diseases also showed no significant difference.ConclusionsDespite the consensus on histopathology, the classification of the chronic and granulomatous types may need further evaluation in clinical considerations.

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Section: Discussioncontrasting

confidence: 64%

Entities of Chronic and Granulomatous Invasive Fungal Rhinosinusitis: Separate or Not?

Zhou

Wang

et al. 2018

Open Forum Infectious Diseases

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“…Purulent, pasty, often foul-smelling material is present within affected sinuses and may contain few or many fungal elements, which often fail to grow in culture. 13 This fungal material is commonly associated with dense polyposis and calcification that results in areas of focal or diffuse radiodensity on computed tomographic imaging of the sinuses 14 ( Fig. 1) and decreased signal intensities on T 1 -and T 2 -weighted magnetic resonance imaging.…”

Section: U Distinguishing Between Invasive and Noninvasive Sinusitismentioning

confidence: 99%

“…15 Since noninvasive and invasive forms have been thought to represent a continuum, reports of "aspergillosis of the sinuses," including those focusing on clinical management, often include both as a single entity. 13 It is now clear that invasive fungal sinusitis can be distinguished from noninvasive disease with the use of clinical criteria that include radiologic diagnosis of sinusitis and histopathological examination of tissue from sinuses ( Table 2). Radiologic findings associated with fungal sinusitis include those also seen with isolated bacterial sinusitis, such as air-fluid levels or more than 8 mm of mucoperiosteal thickening, and those more specific for fungal sinusitis, such as calcifications and loss of bony sinus margins.…”

Section: U Distinguishing Between Invasive and Noninvasive Sinusitismentioning

confidence: 99%

Fungal Sinusitis

deShazo¹,

1997

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“…Invasive aspergillosis (IA) most frequently occurs in the lungs or sinuses of immunocompromised hosts after inhalation of conidia [33,34,35]. Typical risk factors include severe and prolonged neutropenia, high-dose corticosteroid therapy, human immunodeficiency virus (HIV) infection, solid organ transplant, hematopoietic stem cell transplant, and chronic granulomatous disease [36,37,38,39].…”

Section: (1→3)-β-d-glucan (Bdg) In Serummentioning

confidence: 99%

Translational Development and Application of (1→3)-β-d-Glucan for Diagnosis and Therapeutic Monitoring of Invasive Mycoses

McCarthy

Petraitienė

Walsh

2017

IJMS

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Early diagnosis and prompt initiation of appropriate antimicrobial therapy are crucial steps in the management of patients with invasive fungal infections. However, the diagnosis of invasive mycoses remains a major challenge in clinical practice, because presenting symptoms may be subtle and non-invasive diagnostic assays often lack sensitivity and specificity. Diagnosis is often expressed on a scale of probability (proven, probable and possible) based on a constellation of imaging findings, microbiological tools and histopathology, as there is no stand-alone assay for diagnosis. Recent data suggest that the carbohydrate biomarker (1→3)-β-d-glucan may be useful in both the diagnosis and therapeutic monitoring of invasive fungal infections due to some yeasts, molds, and dimorphic fungi. In this paper, we review recent advances in the use of (1→3)-β-d-glucan to monitor clinical response to antifungal therapy and explore how this assay may be used in the future.

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Aspergillosis of the nose and paranasal sinuses

Cited by 188 publications

References 44 publications

Entities of Chronic and Granulomatous Invasive Fungal Rhinosinusitis: Separate or Not?

Entities of Chronic and Granulomatous Invasive Fungal Rhinosinusitis: Separate or Not?

Fungal Sinusitis

Translational Development and Application of (1→3)-β-d-Glucan for Diagnosis and Therapeutic Monitoring of Invasive Mycoses

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