Abstract:Objectives: to assess the bibliometric, clinical and therapeutic features of fungal vertebral osteomyelitis case reports, retrieved from electronic databases. Methods: systematic review with secondary data analysis done on proven cases from Medline, Embase and Lilacs databases and active search of referenced published reports, since 1966 until 2004. Results: there was a growing trend from 1966 to 2004 (R 2 = 0.5518) in the 318 retrieved cases of fungal vertebral osteomyelitis: 218/318 (68.5%) of them from 1990… Show more
“…13,23 Besides intramedullary spinal cord involvement, intradural extramedullary granulomas may occur, as well as epidural bone lesions involving the spinous process, the lamina and the vertebral bodies, causing osteomyelitis and spondylodiscitis. [24][25][26][27][28] There is evidence that the concomitant use of corticosteroids with antifungal therapy can reduce the inflammatory process in patients with PCM. 2 The drugs most used in the antifungal treatment are itraconazole, sulfamethoxazole/trimethoprim, and amphotericin B.…”
Section: Discussionmentioning
confidence: 99%
“…13 23 Besides intramedullary spinal cord involvement, intradural extramedullary granulomas may occur, as well as epidural bone lesions involving the spinous process, the lamina and the vertebral bodies, causing osteomyelitis and spondylodiscitis. 24 25 26 27 28…”
Paracoccidioidomycosis (PCM) is a systemic mycosis caused by fungi Paracoccidioides brasiliensis and Paracoccidiodes Lutzii. Its distribution is limited to subtropical regions of Central and South America, where it is endemic, and Brazil accounts for ∼ 80% of the reported cases. Even in endemic zones, its incidence is low, ranging from 3 to 4 new cases per million to 1 to 3 new cases per 100 thousand inhabitants per year. Granulomas in the spinal cord are rare, and they account for 0,6% of all cases of systemic PCM. The authors report a case of a woman with crural paraparesis caused by dorsal spinal cord PCM granulomasin T7-T8 and T8-T9, with no evidence of systemic disease. The patient was submitted to microsurgery, with total excision of the lesions, and is experiencing positive neurological recovery. Though rare, PCM intramedullary granulomas must be considered in differential diagnosis of the tumoral expansive process of the spinal cord, especially in patients coming from endemic rural zones.
“…13,23 Besides intramedullary spinal cord involvement, intradural extramedullary granulomas may occur, as well as epidural bone lesions involving the spinous process, the lamina and the vertebral bodies, causing osteomyelitis and spondylodiscitis. [24][25][26][27][28] There is evidence that the concomitant use of corticosteroids with antifungal therapy can reduce the inflammatory process in patients with PCM. 2 The drugs most used in the antifungal treatment are itraconazole, sulfamethoxazole/trimethoprim, and amphotericin B.…”
Section: Discussionmentioning
confidence: 99%
“…13 23 Besides intramedullary spinal cord involvement, intradural extramedullary granulomas may occur, as well as epidural bone lesions involving the spinous process, the lamina and the vertebral bodies, causing osteomyelitis and spondylodiscitis. 24 25 26 27 28…”
Paracoccidioidomycosis (PCM) is a systemic mycosis caused by fungi Paracoccidioides brasiliensis and Paracoccidiodes Lutzii. Its distribution is limited to subtropical regions of Central and South America, where it is endemic, and Brazil accounts for ∼ 80% of the reported cases. Even in endemic zones, its incidence is low, ranging from 3 to 4 new cases per million to 1 to 3 new cases per 100 thousand inhabitants per year. Granulomas in the spinal cord are rare, and they account for 0,6% of all cases of systemic PCM. The authors report a case of a woman with crural paraparesis caused by dorsal spinal cord PCM granulomasin T7-T8 and T8-T9, with no evidence of systemic disease. The patient was submitted to microsurgery, with total excision of the lesions, and is experiencing positive neurological recovery. Though rare, PCM intramedullary granulomas must be considered in differential diagnosis of the tumoral expansive process of the spinal cord, especially in patients coming from endemic rural zones.
“…Espec ally the ncrease n the poss b l t es n the f eld of rad ology prov des fac l tates d agnos s. Although there s a l m ted number of b bl ometr c analyzes for spec f c VO publ cat ons n the ava lable l terature [24][25][26][27] , no study provd ng an overv ew was found. In th s study, we a med to g ve a v s on to those who w ll work on VO w th the b blometr c analys s method over the Scopus database.…”
Objective: Vertebral osteomyelitis is defined as an infection of the intervertebral disc and the disc space of the adjacent vertebrae, which causes mortality and morbidity. This disease has started to be detected more frequently due to increased diagnostic possibilities. In this study, we aimed to review the contribution of the increasing number of cases to the scientific literature.
Method: This bibliometric analysis study was carried out by searching the keywords "vertebral osteomyelitis (VO)" or "spondylodiscitis" in Scopus database of Elsevier. English was chosen for the searching language. The distribution of the number of publications by years was evaluated in terms of the institution in which the publications were made, the language of the publication, the country, the author, the institutions providing financial support, the number of citations and the journal in which they were published.
Results: It was determined that there were 2679 publications on vertebral osteomyelitis(VO). First publication was published in 1911. While there was very few publication on this subject until 1937, the number of publications after year 1980s were increased (Graph 1). A total number of 1924 (71.81%) were published after the year 2000. The authors with the highest number of articles in this field were Louis Bernard (16 publications) and Aurélien Dinh (16 publications) from France. A total number of 2576 (96.15%) publications were published in the field of medicine. There were publications on VO in 20 different disciplines, from nursing to veterinary. The publications were consisted of 2123 (79.24%) articles, 261 (9.7%) of them are not categorized, 9 (0.33%) letters to the editor, 150 (5.59%) reviews, and 136 (5.07%) other types of studies (conference papers, notes, book chapters, etc.). The dominant language of publication was English (1992, 74.35%). The most scientifically productive countries on VO were United States (n=452, 16.87%), France (n=303, 11.31%) and Germany (n=248, 9.25%).
Conclusion: It is necessary to support scientific activities on VO and increase the number of publications made globally.
“…Uma vez dentro do osso, as bactérias proliferam e desencadeiam uma resposta inflamatória, resultando em destruição do tecido ósseo (LEW & WALDVOGEL, 2004;HEITZMANN et al, 2019). Outras causas menos comuns podem incluir infecções fúngicas ou parasitárias (FIGUEIREDO et al, 2007).…”
A osteomielite é uma condição inflamatória e infecciosa que afeta o osso, resultando em danos significativos e, em casos graves, até mesmo em complicações potencialmente fatais. Essa infecção óssea pode ser causada por uma variedade de agentes infecciosos e pode surgir de diferentes formas, desde infecções agudas repentinas até infecções crônicas persistentes. O estudo da incidência da osteomielite é de extrema importância devido às suas implicações clínicas e epidemiológicas. Compreender a incidência da osteomielite em diferentes populações e regiões geográficas pode contribuir para o desenvolvimento de políticas de saúde pública direcionadas e programas de prevenção mais assertivos. Dessa forma, o objetivo desse trabalho foi traçar um panorama epidemiológico das internações causadas por osteomielite no Brasil, no período de 2019 a 2023. Trata-se de um estudo ecológico de séries temporais, que usou dados do Sistema de Informações Hospitalares (SIH) do DATASUS. Essa fonte abrangente oferece uma visão detalhada das internações hospitalares causadas por osteomielite no Brasil. Descrevemos uma redução sutil de 4% nas internações hospitalares por osteomielite no Brasil, com o Sudeste sendo responsável pela maioria das internações. Além disso, foi possível identificar que homens, pardos, com idade entre 40 a 49 anos foram os mais acometidos e que a maioria das internações foi em caráter de urgência. Uma sutil redução nas internações por osteomielite é um indicador encorajador no contexto de saúde pública, sugerindo progresso na prevenção, diagnóstico e tratamento dessa condição debilitante. Para manter e expandir essa tendência positiva, é fundamental continuar investindo em educação em saúde, pesquisa clínica e infraestrutura de saúde, garantindo que todos os indivíduos tenham acesso equitativo a serviços de prevenção e tratamento.
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