Asociación de polimorfismos de los genes CRF-BP, SLC6A4 y restricción alimentaria crónica: un estudio preliminar

Sanhueza, J; Herrera, Christian L; Salazar, Luis A.; Silva, Jaime R.

doi:10.4067/s0034-98872011001000003

Cited by 3 publications

(1 citation statement)

References 38 publications

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“…Genotypes of polymorphism rs63749047 (5‐HTTLPR) of the SLC6A4 gene was determined using conventional polymerase chain reaction (PCR) as described by Sanhueza et al . . Polymerase chain reaction conditions were initial denaturation at 98 °C during 5 min and 30 amplification cycles (1 min at 95 °C, 1 min at 61 °C and 1 min at 72 °C).…”

Section: Methodsmentioning

confidence: 99%

Genetic polymorphisms in the serotonergic system are associated with circadian manifestations of bruxism

Oporto

Bornhardt

Iturriaga

et al. 2016

J of Oral Rehabilitation

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Bruxism (BRX) is a condition of great interest for researchers and clinicians in dental and medical areas. BRX has two circadian manifestations; it can occur during sleep (sleep bruxism, SB) or during wakefulness (awake bruxism, WB). However, it can be suffered together. Recent investigations suggest that central nervous system neurotransmitters and their genes could be involved in the genesis of BRX. Serotonin is responsible for the circadian rhythm, maintaining arousal, regulating stress response, muscle tone and breathing. Thus, serotonin could be associated with BRX pathogenesis. The aim of this work was to evaluate the frequency of genetic polymorphisms in the genes HTR1A (rs6295), HTR2A (rs1923884, rs4941573, rs6313, rs2770304), HTR2C (rs17260565) and SLC6A4 (rs63749047) in subjects undergoing BRX treatment. Patients included were classified according to their diagnosis in awake bruxism (61 patients), sleep bruxism (26 patients) and both (43 patients). The control group included 59 healthy patients with no signs of BRX. Data showed significant differences in allelic frequencies for the HTR2A rs2770304 polymorphism, where the C allele was associated with increased risk of SB (odds ratio = 2·13, 95% confidence interval: 1·08-4·21, P = 0·03). Our results suggest that polymorphisms in serotonergic pathways are involved in sleep bruxism. Further research is needed to clarify and increase the current understanding of BRX physiopathology.

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Section: Methodsmentioning

confidence: 99%

Genetic polymorphisms in the serotonergic system are associated with circadian manifestations of bruxism

Oporto

Bornhardt

Iturriaga

et al. 2016

J of Oral Rehabilitation

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The Genetics of Eating Disorders

Trace¹,

Baker²,

Peñas-Lledó

et al. 2013

Annu. Rev. Clin. Psychol.

183

115

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Over the past decade, considerable advances have been made in understanding genetic influences on eating pathology. Eating disorders aggregate in families, and twin studies reveal that additive genetic factors account for approximately 40% to 60% of liability to anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED). Molecular genetics studies have been undertaken to identify alterations in deoxyribonucleic acid sequence and/or gene expression that may be involved in the pathogenesis of disordered eating behaviors, symptoms, and related disorders and to uncover potential genetic variants that may contribute to variability of treatment response. This article provides an in-depth review of the scientific literature on the genetics of AN, BN, and BED including extant studies, emerging hypotheses, future directions, and clinical implications.

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Biology of Stress and Physical Performance

Silva¹,

Bahamondes-Avila²,

ClaudioHernández-Mosqueira³

et al. 2018

Sport and Exercise Science

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Regular physical training leads to physical capacity and optimal sports performance, and although this relationship is usually linear, the athlete's adaptation is conditioned by multiple factors: environmental, genetic and psychological. Studies have shown that between 70 and 85% of successful and unsuccessful athletes can be identiied using psychological measures of personality and mood, a level higher than chance, but insuicient for the purpose of selecting athletes. The research indicates that the mood of the athletes exhibits a dose-response relationship with their adaptation to the training load; This inding has shown potential to reduce the incidence of overtraining syndrome in athletes who undergo rigorous physical training, through early detection using scales of perception of their mood and physiological measures such as the testosterone / cortisol index. Thus, the genetic and epigenetic modiications of the factors that regulate the hypothalamic-pituitary-adrenal axis and, therefore, the response to stress, have recently been associated with a detrimental efect on physical performance and early manifestations of the overtraining syndrome and the abandonment of training and competences.

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Asociación de polimorfismos de los genes CRF-BP, SLC6A4 y restricción alimentaria crónica: un estudio preliminar

Cited by 3 publications

References 38 publications

Genetic polymorphisms in the serotonergic system are associated with circadian manifestations of bruxism

Genetic polymorphisms in the serotonergic system are associated with circadian manifestations of bruxism

The Genetics of Eating Disorders

Biology of Stress and Physical Performance

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