2016
DOI: 10.1590/1806-9282.62.07.680
|View full text |Cite
|
Sign up to set email alerts
|

Ascorbic acid in the prevention and treatment of cancer

Abstract: Mata aMOF da et al. 680rev assoC med bras 2016; 62(7):680-686 This review is aimed at the systematic mapping of ascorbic acid in the prevention and/or treatment of cancer in clinical and non-clinical studies from 2011 to 2015, in order to understand dose-response variations as well as its mechanisms of action as an antioxidant and antitumor agent. Seventy-eight articles were retrieved from the PubMed/Bireme database, of which only 30 included ascorbic acid in the prevention and/or treatment of cancer. However,… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
25
0

Year Published

2017
2017
2023
2023

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 24 publications
(25 citation statements)
references
References 47 publications
0
25
0
Order By: Relevance
“…Vitamin C is an important antioxidant and an essential nutrient (21), and the results of the present study suggest that it exhibits an anti-tumor activity through promoting apoptosis. Mata et al (22) conducted a series of non-clinical studies using different tumor cell lineages to examine the effect of different concentrations of vitamin C for the treatment and/or prevention of these types of cancer. They demonstrated that vitamin C at a concentration range of 0.1-4 mM significantly inhibited the proliferation of these cancer cell lines (22).…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…Vitamin C is an important antioxidant and an essential nutrient (21), and the results of the present study suggest that it exhibits an anti-tumor activity through promoting apoptosis. Mata et al (22) conducted a series of non-clinical studies using different tumor cell lineages to examine the effect of different concentrations of vitamin C for the treatment and/or prevention of these types of cancer. They demonstrated that vitamin C at a concentration range of 0.1-4 mM significantly inhibited the proliferation of these cancer cell lines (22).…”
Section: Discussionmentioning
confidence: 99%
“…Mata et al (22) conducted a series of non-clinical studies using different tumor cell lineages to examine the effect of different concentrations of vitamin C for the treatment and/or prevention of these types of cancer. They demonstrated that vitamin C at a concentration range of 0.1-4 mM significantly inhibited the proliferation of these cancer cell lines (22). Chen et al (6)(7)(8) additionally demonstrated that the growth and weight of ovarian, pancreatic and glioblastoma tumor xenografts in athymic nude mice decreased when intraperitoneally injected with vitamin C, and they demonstrated that mM concentrations of vitamin C killed cancer cells, but had less of an effect on normal cells (23).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…An example of these compounds is ascorbic acid. At higher concentrations, ascorbic acid might enhance production of ATP and induce apoptosis in tumor cells through a pro-oxidant mechanism (Mata et al, 2016).…”
Section: 06% Of Identified Components Present In the Eo)mentioning
confidence: 99%
“…These products of HDIVC were found to kill cancer cells while leaving normal tissue unharmed [13][14]. A meta-analysis of Vitamin C and cancer apoptosis reviews some of the mechanisms involved [15].…”
Section: Methodsmentioning
confidence: 99%