Ascorbic acid absorption in man: influence of divided dose and food

Yung, Susanna; Mayersohn, Michael; Robinson, J. B.

doi:10.1016/0024-3205(81)90592-0

Cited by 19 publications

(6 citation statements)

References 9 publications

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“…Compounds transported by specialized processes are generally absorbed only at certain sites along the gastrointestinal tract. This has been illustrated for riboflavin, the absorption of which proceeds from the upper regions of the small intestine (33,34), and appears to be the case for AA as well (35). As a result, factors altering gastric emptying and intestinal transit rates (e.g., food and drugs) may influence the efficiency of absorption from the oral dosage form.…”

Section: Resultsmentioning

confidence: 94%

In Vitro Gastrointestinal Digestion Study of Pomegranate Juice Phenolic Compounds, Anthocyanins, and Vitamin C

Pérez-Vicente

Gil-Izquierdo

García‐Viguera

2002

J. Agric. Food Chem.

290

169

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Pomegranate is an important source of bioactive compounds, such as anthocyanins, other phenolic compounds, and ascorbic acid. In the present work an in vitro availability method has been used to assay the influence of the physiological conditions in the stomach and small intestine. This method enables the study of the release of anthocyanins, vitamin C, and total phenols from the pomegranate juice and their transformations during gastrointestinal digestion. Results have shown that pomegranate phenolic compounds are available during the digestion in a quite high amount (29%). Nevertheless, due to pH, anthocyanins are largely transformed into non-red forms and/or degraded (97%), and similar results are obtained for vitamin C (>95% degradation).

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Section: Resultsmentioning

confidence: 94%

In Vitro Gastrointestinal Digestion Study of Pomegranate Juice Phenolic Compounds, Anthocyanins, and Vitamin C

Pérez-Vicente

Gil-Izquierdo

García‐Viguera

2002

J. Agric. Food Chem.

290

169

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“…It is likely that plasma concentrations in the supplemented group after exercise represent the sum of both vitamin C delivered orally and that released endogenously as a consequence of exercise. The high concentrations achieved may also reflect the fact that we administered vitamin C with a light meal to prolong gastric emptying [37]. Furthermore the meal also contained sodium, which facilitates the uptake of vitamin C [20].…”

Section: Discussionmentioning

confidence: 99%

Muscle Soreness and Damage Parameters after Prolonged Intermittent Shuttle-Running Following Acute Vitamin C Supplementation

Thompson

Williams²,

Kingsley³

et al. 2001

Int J Sports Med

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Exercise-induced free-radical production may be partly responsible for muscle soreness and damage following demanding exercise. A number of studies have investigated the effect of antioxidant supplementation although there is a paucity of information regarding vitamin C. Therefore the aim of the present study was to investigate the effect of vitamin C supplementation on exercise-induced muscle soreness and damage. Nine habitually active males consumed a 1 g dose of vitamin C 2 h before exercise, and on another occasion consumed an identical placebo. The exercise comprised a 90 min intermittent shuttle-running test, which was designed to simulate the multiple-sprint sports. Vitamin C supplementation increased plasma concentrations of vitamin C before exercise, and plasma concentrations continued to increase during the shuttle-run to reach a peak of approximately 200 micromol x l(-1) immediately after exercise. However, muscle soreness, and markers of both muscle damage (creatine kinase and aspartate aminotransferase) and lipid peroxidation (malondialdehyde) were elevated to an equal extent after exercise in placebo and supplemented trials. Therefore acute supplementation with vitamin C had no beneficial effects although it is possible that such short-term vitamin C supplementation was ineffective because it occurred at an inappropriate time.

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“…The absorption effi ciency of a single dose can be improved if the ascorbate is ingested in the form of a sustained-release capsule (Sacharin et al, 1976). The ingestion of 1 g of ascorbate immediately after a fatty meal produced a 69% increase in absorption compared to the same dose given on an empty stomach (Yung et al, 1981). The divided dose effect is consistent with a saturable absorption mechanism, while the after-meal effect indicates a slowing of gastric emptying.…”

Section: Effi Ciency Of Ascorbate Absorption In Humansmentioning

confidence: 72%

“…The ingestion of eight 0.125-g doses of ascorbate spaced throughout the day produced a 72% increase in absorption compared to a single 1-g dose (Yung et al, 1981). The absorption effi ciency of a single dose can be improved if the ascorbate is ingested in the form of a sustained-release capsule (Sacharin et al, 1976).…”

Section: Effi Ciency Of Ascorbate Absorption In Humansmentioning

confidence: 99%

Vitamin C

Ball¹

2004

Vitamins

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Ascorbic acid absorption in man: influence of divided dose and food

Cited by 19 publications

References 9 publications

In Vitro Gastrointestinal Digestion Study of Pomegranate Juice Phenolic Compounds, Anthocyanins, and Vitamin C

In Vitro Gastrointestinal Digestion Study of Pomegranate Juice Phenolic Compounds, Anthocyanins, and Vitamin C

Muscle Soreness and Damage Parameters after Prolonged Intermittent Shuttle-Running Following Acute Vitamin C Supplementation

Vitamin C

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