Muscle Soreness and Damage Parameters after Prolonged Intermittent Shuttle-Running Following Acute Vitamin C Supplementation

Abstract

Exercise-induced free-radical production may be partly responsible for muscle soreness and damage following demanding exercise. A number of studies have investigated the effect of antioxidant supplementation although there is a paucity of information regarding vitamin C. Therefore the aim of the present study was to investigate the effect of vitamin C supplementation on exercise-induced muscle soreness and damage. Nine habitually active males consumed a 1 g dose of vitamin C 2 h before exercise, and on another occasion consumed an identical placebo. The exercise comprised a 90 min intermittent shuttle-running test, which was designed to simulate the multiple-sprint sports. Vitamin C supplementation increased plasma concentrations of vitamin C before exercise, and plasma concentrations continued to increase during the shuttle-run to reach a peak of approximately 200 micromol x l(-1) immediately after exercise. However, muscle soreness, and markers of both muscle damage (creatine kinase and aspartate aminotransferase) and lipid peroxidation (malondialdehyde) were elevated to an equal extent after exercise in placebo and supplemented trials. Therefore acute supplementation with vitamin C had no beneficial effects although it is possible that such short-term vitamin C supplementation was ineffective because it occurred at an inappropriate time.

Molecular detection of exercise-induced free radicals following ascorbate prophylaxis in type 1 diabetes mellitus: a randomised controlled trial

“…Plasma ascorbic acid concentration rose by 61.5% following ascorbic acid ingestion, agreeing with the work of Thompson et al [37]. However, what is unknown from the present research is the specific site of free radical scavenging.…”

Gender differences in biochemical markers and oxidative stress of rats after 28 days oral exposure to a mixture used for weight loss containing p-synephrine, ephedrine, salicin, and caffeine

“…Both p-synephrine and ephedrine are structurally and pharmacologically related to amphetamine (Firenzuoli et al, 2005), which could be associated to the oxidative stress seen in this study. Caffeine-derived effects could favor the production of free radicals and a subsequent increase in oxidative stress such as the metabolic inactivation of catecholamines (Halliwell, Gutteridge, 1985;Jewett et al, 1989) and the increase in oxidative metabolism (Shigenaga et al, 1994;Thompson et al, 2001) including its own hepatic metabolism (Vistisen et al, 1992). There are also reports suggesting that caffeine is capable of inducing certain forms of oxidative damage by increasing lipid peroxidation (Dianzani et al, 1991).…”

Effects of 808 nm low‐power laser irradiation on the muscle contraction of frog gastrocnemius

“…Tools such as nutritional supplements, fluid reposition, vitamin C, creatine and arginine have been used to prevent muscle fatigue in healthy subjects as well as in pathological conditions [22][23][24][25][26]. LLI is a novel therapy form that has been used to treat muscular fatigue/pain; however, the biological mechanisms that underlie the beneficial results observed in clinical trials remain unclear [27].…”