Molecular detection of exercise-induced free radicals following ascorbate prophylaxis in type 1 diabetes mellitus: a randomised controlled trial

Davison, Gareth W.; Ashton, Tony; George, L.; Young, Ian S.; McEneny, Jane; Davies, Bruce; Jackson, Simon K.; Peters, John R.; Bailey, Damian Miles

doi:10.1007/s00125-008-1101-1

Cited by 26 publications

(16 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, aerobic50 51 and anaerobic52 exercise has been shown to cause an oxidative stress response on the body; therefore, inducing oxidative damage during a ‘recovery’ period may further exacerbate muscle stress and delay the recovery process. Moreover, should cold immersion reduce body temperature to a level that initiates non-voluntary shivering thermogenesis, the resultant increase in resting metabolism may unnecessarily cause oxidation to stored muscle glycogen and triglyceride levels, and, in doing so, further hamper the recovery process prior to exercise.…”

Section: Discussionmentioning

confidence: 99%

What is the biochemical and physiological rationale for using cold-water immersion in sports recovery? A systematic review

2009

View full text Add to dashboard Cite

Cold-water immersion (CWI) is a popular recovery intervention after exercise. The scientific rationale is not clear, and there are no clear guidelines for its use. The aim of this review was to study the physiological and biochemical effect of short periods of CWI. A computer-based literature search, citation tracking and related articles searches were undertaken. Primary research studies using healthy human participants, immersed in cold water (<15 degrees C), for 5 min durations or less were included. Data were extracted on body temperature, cardiovascular, respiratory and biochemical response. 16 studies were included. Sample size was restricted, and there was a large degree of study heterogeneity. CWI was associated with an increase in heart rate, blood pressure, respiratory minute volume and metabolism. Decreases in end tidal carbon dioxide partial pressure and a decrease in cerebral blood flow were also reported. There was evidence of increases in peripheral catecholamine concentration, oxidative stress and a possible increase in free-radical-species formation. The magnitude of these responses may be attenuated with acclimatisation. CWI induces significant physiological and biochemical changes to the body. Much of this evidence is derived from full body immersions using resting healthy participants. The physiological and biochemical rationale for using short periods of CWI in sports recovery still remains unclear.

show abstract

Section: Discussionmentioning

confidence: 99%

What is the biochemical and physiological rationale for using cold-water immersion in sports recovery? A systematic review

2009

View full text Add to dashboard Cite

show abstract

“…Reported by the kit manufacturer; 2(Bowtell et al 2011); 3(Davison et al 2008). sTnI, skeletal troponin I fast form; MMP-9, matrix metalloproteinase-9; IL-6, interleukin-6; IL-10, interleukin-10; CK, creatine kinase; hsCRP, high sensitivity c-reactive protein; PC, protein carbonyls; LOOH, lipid hydroperoxides; Ascorbyl, ascorbyl free radical.…”

mentioning

confidence: 99%

Assessing the usefulness of acute physiological responses following resistance exercise: sensitivity, magnitude of change, and time course of measures

Jackman

Bell

Gill

et al. 2019

Appl. Physiol. Nutr. Metab.

View full text Add to dashboard Cite

A variety of strategies exist to modulate acute physiological responses following resistance exercise aimed at enhancing recovery and/or adaptation processes. To assess the true impact of these strategies, it is important to know the ability of measures to detect meaningful change. We investigated the sensitivity of measures used to quantify acute physiological responses to resistance exercise and constructed a physiological profile to characterise the magnitude of change and time course of this response. Eight males, accustomed to regular resistance exercise, performed experimental sessions during a 'control week', void of an exercise stimulus. Participants repeated this sequence of experimental sessions the following week, termed the 'exercise week', except they performed a bout of lower-limb resistance exercise following baseline assessments. Assessments were conducted at baseline, 2, 6, 24, 48, 72 and 96 h post-intervention. Based on the signal-to-noise ratio, the most sensitive measures were maximal voluntary isometric contraction, 20m sprint, countermovement jump peak force, rate of force development (100-200ms), muscle soreness, daily analysis of life demands for athletes Part B, limb girth, matrix metalloproteinase-9, interleukin-6, creatine kinase and high sensitivity C-reactive protein with ratios of >1.5. There were clear changes in these measures following resistance exercise, determined via magnitude-based inferences. These findings highlight measures that can detect real changes in acute physiological responses following resistance exercise in trained individuals. Researchers investigating strategies to manipulate acute physiological responses for recovery and/or adaptation can use these measures, as well as recommended sampling points, to be confident that their interventions are making a worthwhile impact.

show abstract

“…Oxidation of vascular lipid-membranes can generate lipid hydroperoxides through the exercise-induced production of molecular free radical species [ 14 ]. This decomposition of polyunsaturated fatty acids can produce an array of mutagenic compounds, and damaging intermediates, including alkoxyl free radicals [ 52 ] and malondialdehyde [ 49 ]; both molecules are capable of directly damaging DNA, whilst alkoxyl free radicals may perpetuate lipid peroxidation [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Exogenous Plant-Based Nutraceutical Supplementation and Peripheral Cell Mononuclear DNA Damage Following High Intensity Exercise

Williamson

Hughes²,

Davison

2018

Antioxidants

View full text Add to dashboard Cite

Plant-based nutraceuticals are categorised as nutritional supplements which contain a high concentration of antioxidants with the intention of minimising the deleterious effect of an oxidative insult. The primary aim of this novel study was to determine the effect of exogenous barley-wheat grass juice (BWJ) on indices of exercise-induced oxidative stress. Ten (n = 10) apparently healthy, recreationally trained (V̇O2max 55.9 ± 6 mL·kg−1·min−1), males (age 22 ± 2 years, height 181 ± 6 cm, weight 87 ± 8 kg, body mass index (BMI) 27 ± 1) volunteered to participant in the study. In a randomised, double-blinded, placebo-controlled crossover design, participants consumed either a placebo, a low dose (70 mL per day) of BWJ, or a high dose (140 mL per day) of BWJ for 7-days. Experimental exercise consisted of a standard maximal oxygen uptake test until volitional fatigue. DNA damage, as assessed by the single cell gel electrophoresis comet assay, increased following high intensity exercise across all groups (time × group; p < 0.05, Effect Size (ES) = 0.7), although there was no selective difference for intervention (p > 0.05). There was a main effect for time in lipid hydroperoxide concentration (pooled-group data, pre- vs. post-exercise, p < 0.05, ES = 0.2) demonstrating that exercise increased lipid peroxidation. Superoxide dismutase activity (SOD) increased by 44.7% following BWJ supplementation (pooled group data, pre- vs. post). The ascorbyl free radical (p < 0.05, ES = 0.26), α-tocopherol (p = 0.007, ES = 0.2), and xanthophyll (p = 0.000, ES = 0.5), increased between the pre- and post-exercise time points indicating a main effect of time. This study illustrates that a 7-day supplementation period of a novel plant-derived nutraceutical product is insufficient at attenuating exercise-induced oxidative damage. It is possible that with a larger sample size, and longer supplementation period, this novel plant-based nutraceutical could potentially offer effective prophylaxis against exercise-induced oxidative stress; as such, this justifies the need for further research.

show abstract

Molecular detection of exercise-induced free radicals following ascorbate prophylaxis in type 1 diabetes mellitus: a randomised controlled trial

Cited by 26 publications

References 42 publications

What is the biochemical and physiological rationale for using cold-water immersion in sports recovery? A systematic review

What is the biochemical and physiological rationale for using cold-water immersion in sports recovery? A systematic review

Assessing the usefulness of acute physiological responses following resistance exercise: sensitivity, magnitude of change, and time course of measures

Exogenous Plant-Based Nutraceutical Supplementation and Peripheral Cell Mononuclear DNA Damage Following High Intensity Exercise

Contact Info

Product

Resources

About