Arterial Stiffness Is the Independent Factor of Left Ventricular Hypertrophy Determined by Electrocardiogram

Chung, Chang-Min; Lin, Yu‐Sheng; Chang, Shih-Tai; Cheng, Hui-Wen; Yang, Teng-Yao; Hsiao, Ju-Feng; Pan, Kuo‐Li; Hsu, Jen-Te; Chu, Chi‐Ming

doi:10.1097/maj.0b013e318242a354

Cited by 34 publications

(28 citation statements)

References 23 publications

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“…Numerous studies have reported a positive correlation between increased LVMI and baPWV [26, 27]. Arterial stiffness may contribute to LVH independently of BP [26, 28]. Our current study showed that risk of LVH rose markedly in patients with baPWV>16m/s.…”

Section: Discussionsupporting

confidence: 65%

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Incidence and predictors of left ventricular remodeling among elderly Asian women: a community-based cohort study

Fan

et al. 2017

BMC Geriatr

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BackgroundLeft ventricular (LV) remodeling is closely linked to the progression of heart failure. There are limited data on the epidemiology of new onset LV remodeling among elderly women, which requires further investigation.MethodWe examined data from a community-based cohort of women aged > 65 years, who had received > 2 echocardiography scans from 2009 to 2014. Exclusion criteria for patients included prior echocardiographic evidence of left ventricular enlargement (LVE) or hypertrophy (LVH). LVE was defined as the index of left ventricular internal diameter at end-diastole to height, and LVH was defined as the left ventricular mass and thickness index which indicate hypertrophy.ResultsOf the 474 subjects (age 71.85 ± 6.47 years), 49 (10.3%) developed LVH, while 55 (11.6%) developed LVE during the mean follow-up period of 5 years. Independent predictors of LVH included: central blood pressure (CBP, per 10 mmHg) [HR 1.094, 95% CI 1.011–1.202], BMI˃25(kg/m 2)[HR 1.306, 95% CI 1.175–1.434], B-type natriuretic peptide (BNP) ≥ 100 (pg/mL) [HR 1.635, 95% CI 1.107–3.311] and brachial-ankle pulse wave velocity (baPWV) ≥16 m/s [HR 1.605, 95% CI 1.474–2.039]. Predictors of LVE were CBP (per 10 mmHg) [HR 1.121, 95% CI 1.027–1.238], BMI˃25(kg/m 2)[HR 1.302, 95% CI 1.173–1.444], Low-density lipoprotein cholesterol (LDL-C) [HR 1.193, 95%CI 1.013–1.405] and E/e’ ratio [HR 1.077, 95% CI 1.017–1.140].ConclusionCBP and BMI were demonstrated to be independent and robust predictors of left ventricular remodeling among elderly women, including both LVE and LVH. BNP and baPWV were specifically related to the development of LVH, whereas LDL-C and E/e’ ratio were related to LVE.

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Section: Discussionsupporting

confidence: 65%

“…BaPWV is a promising technique to assess arterial stiffness in large population-based investigations [25]. Numerous studies have reported a positive correlation between increased LVMI and baPWV [26, 27]. Arterial stiffness may contribute to LVH independently of BP [26, 28].…”

Section: Discussionmentioning

confidence: 99%

Incidence and predictors of left ventricular remodeling among elderly Asian women: a community-based cohort study

Fan

et al. 2017

BMC Geriatr

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“…Some studies have reported a positive correlation between PWV and increased LVMI and LVH [35]–[37]. Arterial stiffness is associated with hypertrophy and atherosclerosis within the capacitance arteries that result in an increase in PWV and consequent alterations in the pressure waveform and increases in systolic and pulse pressure.…”

Section: Discussionmentioning

confidence: 99%

Association of Bilateral Brachial-Ankle Pulse Wave Velocity Difference with Peripheral Vascular Disease and Left Ventricular Mass Index

Lin

Hsu

et al. 2014

PLoS ONE

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Unequal arterial stiffness had been associated with cardiovascular risks. We investigated whether an association existed between unequal arterial stiffness indicated by bilateral brachial-ankle pulse wave velocity (baPWV) difference and ankle-brachial index (ABI), baPWV, echocardiographic parameters and interarm and interankle systolic blood pressure (BP) differences. A total of 1111 patients referred for echocardiographic examination were included in this study. The BPs, ABI and baPWV were measured simultaneously by an ABI-form device. The ΔbaPWV was defined as absolute value of difference between bilateral baPWV. We performed three multivariate analyses for determining the factors associated with a ΔbaPWV ≧ 185 cm/s (90 percentile of ΔbaPWV) (model 1: significant variables in univariate analysis and ABI <0.9 and baPWV; model 2: significant variables in univariate analysis and left ventricular mass index [LVMI]; model 3: significant variables in univariate analysis and interankle systolic BP difference ≧ 15 mmHg). The ABI <0.9 and high baPWV (both P<0.001) in model 1, high LVMI (P = 0.021) in model 2 and an interankle systolic BP difference ≧ 15 mmHg (P = 0.026) in model 3 were associated with a ΔbaPWV ≧ 185 cm/s, but the interarm systolic BP difference ≧ 10 mmHg was not (P = NS). Our study demonstrated ABI <0.9, high baPWV, high LVMI and an interankle systolic BP difference ≧ 15 mmHg were associated with unequal arterial stiffness.

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“…Changes in wave reflections and increased stiffness have also been reported to contribute to LVH [91]. Moreover, previous studies have reported a positive correlation between PWV, a marker of arterial stiffness, and increases in LVMI and LVH [100][101][102].…”

Section: Pwvmentioning

confidence: 91%

Prognostic Cardiovascular Markers in Chronic Kidney Disease

Chen

Huang

et al. 2018

Kidney Blood Press Res

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Chronic kidney disease (CKD), including end-stage renal disease (ESRD), is a public health issue worldwide, and is associated with high rates of morbidity and mortality. In addition, cardiovascular disease is a major cause of mortality in these patients. Both traditional and nontraditional risk factors associated with CKD can lead to remodeling of the myocardium and blood vessels, thereby resulting in cardiomyopathy, atherosclerosis and arterial stiffness. This can subsequently lead to ischemic heart disease, heart failure, cardiovascular death, rapid renal progression and progression to ESRD. Identifying these risk factors to allow for aggressive preventive and interventional strategies is important for the management of patients with CKD. This aim of this review was to survey the clinical outcomes of CKD using cardiac and vascular markers including echocardiographic parameters, systolic time intervals, electrocardiography, heart rate variability, ankle-brachial index, pulse wave velocity, differences between interarm and interankle blood pressure, and vascular calcification.

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Arterial Stiffness Is the Independent Factor of Left Ventricular Hypertrophy Determined by Electrocardiogram

Cited by 34 publications

References 23 publications

Incidence and predictors of left ventricular remodeling among elderly Asian women: a community-based cohort study

Incidence and predictors of left ventricular remodeling among elderly Asian women: a community-based cohort study

Association of Bilateral Brachial-Ankle Pulse Wave Velocity Difference with Peripheral Vascular Disease and Left Ventricular Mass Index

Prognostic Cardiovascular Markers in Chronic Kidney Disease

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