Arterial Stiffness Is Significantly Associated With Left Ventricular Diastolic Dysfunction in Patients With Cardiovascular Disease

Abstract

SummaryLeft ventricular (LV) diastolic dysfunction is considered the main cause of heart failure with preserved ejection fraction (HFpEF). There have been few reports on the correlation between LV diastolic dysfunction and arterial stiffness in patients with clinical cardiovascular disease.This cross-sectional study enrolled 100 patients (67 men, 33 women; mean age, 70 years). All participants were diagnosed with cardiovascular disease. A total of 89 (89%) patients had coronary artery disease or HF. Patients with reduced EF and valvular disease were excluded. Arterial stiffness was assessed by the cardio-ankle vascular index (CAVI), and LV diastolic dysfunction was estimated using echocardiography. The patients were divided into two groups based on the median value of CAVI. In all patients the ratio of early diastolic transmitral flow velocity to early diastolic mitral annular velocity (E/e') was significantly higher in the high CAVI group than in the low CAVI group (15.5 ± 6.4 versus 12.5 ± 2.9, P = 0.003). In the HF subgroup, E/e' was also significantly higher in the high CAVI group than in the low CAVI group (17.2 ± 5.9 versus 13.0 ± 3.1, P = 0.026). In univariate regression analysis, CAVI was significantly associated with E/e' in all patients (β = 0.28, P = 0.004) and in HF patients (β = 0.4, P = 0.028). Also in multivariate analysis, CAVI remained as an independent predictive factor of E/e' (β = 0.252, P = 0.037).A high CAVI was independently associated with LV diastolic dysfunction in patients with clinical cardiovascular disease. These results suggested that arterial stiffness contributed to the development of LV diastolic dysfunction. (Int Heart J 2016; 57: 729-735)

Detection of Apolipoprotein E Gene Polymorphism and Blood Lipid Level in Hemodialysis Patients

“…Decrease of HDLC levels is mainly related to inadequate dialysis and malnutrition. It has been reported that 50-70% of hemodialysis patients had increased plasma Lp(a) levels, higher than 0.3 g/L, inconsistent with the results of this article [8, 23], perhaps due to different conditions, different ways, different time to start doing hemodialysis and treatment course, and all the above factors can affect the metabolism of Lp(a) [22]; Lp(a) level was increased significantly in diabetic patients; however, it was found irrelevant to diabetes in this study. In addition, variability of Lp(a) levels is huge dependent on the size of samples.…”

Early Diastolic Left Ventricular Relaxation in Normal Neonates is Influenced by Ventricular Stiffness and Longitudinal Systolic Function

“…E, A, E/ A, and E/e' are known as other Doppler indices for evaluating left ventricular diastolic function. 5,6) However, E, A, and E/A need careful interpretation, since these show a 'pseudonormal or restrictive filling pattern' in advanced diastolic dysfunction. E and A are combined in one component in increased heart rate, which is likely to occur in neonates.…”

Factors Associated With Pathological Cardio-Ankle Vascular Index in Patients With Acute Ischemic Stroke

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