Arterial Spin-Labeling and MR Spectroscopy in the Differentiation of Gliomas

Abstract

BACKGROUND AND PURPOSE:Noninvasive grading of gliomas remains a challenge despite its important role in the prognosis and management of patients with intracranial neoplasms. In this study, we evaluated the ability of cerebral blood flow (CBF)-guided voxel-by-voxel analysis of multivoxel proton MR spectroscopic imaging ( 1 H-MRSI) to differentiate low-grade from high-grade gliomas.

MRI Grading versus Histology: Predicting Survival of World Health Organization Grade II-IV Astrocytomas

“…10,11,13,14,[21][22][23][24] The results for DWI have been conflicting, 13,21 as they have for the presence of magnetic susceptibility suggestive of hemorrhage. 25,26 A practical difficulty with the advanced sequences is that they are generally continuous variables, with at least some overlap between tumors of different grades.…”

Using magnetic resonance imaging and spectroscopy in cancer diagnostics and monitoring

“…51 ASL studies of human brain tumors, however, show heterogeneous perfusion patterns. [52][53][54] This is not unexpected in the light of known heterogeneity of oxygenation in many brain tumor types. Interestingly, ASL perfusion measurements indicate that astrocytic tumors can be graded as low or high grade tumors by means of quantitative perfusion.…”

“…Interestingly, ASL perfusion measurements indicate that astrocytic tumors can be graded as low or high grade tumors by means of quantitative perfusion. Low grade gliomas show lower maximum perfusion than high grade gliomas, [52][53][54] yet the global perfusion in all glioma classes does not differ. 54 High grade gliomas show higher blood flow than CNS lymphomas.…”

“…Low grade gliomas show lower maximum perfusion than high grade gliomas, [52][53][54] yet the global perfusion in all glioma classes does not differ. 54 High grade gliomas show higher blood flow than CNS lymphomas. 52 These studies are very promising toward the use of ASL MRI for both presurgical brain tumor grading as well as for monitoring treatment responses, for instance in the case of anti-angiogenic drugs.…”

Brain Tumour Disease Pattern Identification from Metabolites in Magnetic Resonance Spectroscopy Graph using Data Mining Techniques

“…MRS is an important technique widely used by all radiologists as one of the method for diagnosing and evaluating common brain tumours.MRS can show abnormal findings in nearly 100% of brain tumors and in some instances it can be used for differential diagnosis of brain tumours [1] [2].…”