BACKGROUND AND PURPOSE:Noninvasive grading of gliomas remains a challenge despite its important role in the prognosis and management of patients with intracranial neoplasms. In this study, we evaluated the ability of cerebral blood flow (CBF)-guided voxel-by-voxel analysis of multivoxel proton MR spectroscopic imaging ( 1 H-MRSI) to differentiate low-grade from high-grade gliomas.

BACKGROUND AND PURPOSE:Oligodendrogliomas with 1p/19q chromosome LOH are more sensitive to chemoradiation therapy than those with intact alleles. The usefulness of dynamic susceptibility contrast-PWI-guided 1 H-MRS in differentiating these 2 genotypes was