Arterial pre‐hypertension and hypertension in intracranial versus extracranial cerebrovascular stenosis

Wang, D.; Zhou, Yong; Lee, Hyewon; Wang, C.; Wang, Anxin; Jin, Zening; Gao, Xiang; Wu, Shouling; Wang, Wenjuan; Jonas, Jost B.

doi:10.1111/ene.12611

Cited by 16 publications

(16 citation statements)

References 41 publications

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“…Smoking or drinking cessation was considered only if it lasted for at least 1 year. Body weight and body height were measured, and the body mass index (BMI) was calculated as body weight (kg) divided by the square of height (m 2 ) [11]. Arterial hypertension was defined as self- reported history of hypertension, taking antihypertensive medication or by a systolic blood pressure of ≥140 mm Hg or a diastolic blood pressure of ≥90 mm Hg.…”

Section: Methodsmentioning

confidence: 99%

Asymptomatic carotid artery stenosis and retinal nerve fiber layer thickness. A community-based, observational study

Wang

Zhou

et al. 2017

PLoS ONE

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PurposeTo examine whether an abnormally thin retinal nerve fiber layer (RNFL) is associated with cerebrovascular insufficiency.DesignCommunity-based study.MethodsThe Asymptomatic Polyvascular Abnormalities in Community Study included Chinese aged 40+ years and without histories of cerebrovascular incidents or coronary heart disease. Using transcranial Doppler and carotid duplex ultrasound examination, we assessed presence and degree of an intracranial arterial stenosis (ICAS) and extracranial carotid arterial stenosis (ECAS) and we measured the RNFL thickness by spectral-domain optical coherence tomography.ResultsThe study included 3,376 participants with a mean age of 54.3±10.3 years. Thinner RNFL was significantly correlated with a higher prevalence of ECAS (P = 0.035; standardized regression coefficient beta:-0.04; non-standardized regression coefficient B:-0.99; 95% confidence intervals(CI):-1.90,-0.07), after adjusting for age (P<0.001;beta:-0.25;B:-0.26;95%CI:-0.30,-0.22), gender (P = 0.001;beta:-0.07;B:-1.36;95%CI:-2.14,-0.58) and blood concentration of low-density lipoproteins (P = 0.03;beta:0.04;B:0.52;95%CI:0.05,0.98). In a reverse manner, prevalence of ECAS was associated with a thinner RNFL thickness (P = 0.007; odds ratio (OR):0.99; 95%CI:0.98,0.99) after adjusting for older age (P<0.001;OR:1.06;95%CI:10.05,10.7), higher prevalence of ICAS (P = 0.01;OR:1.34;95%CI:1.07,1.69) and higher prevalence of carotid artery plaques (P<0.001;OR:9.18;95%CI:6.93,12.2), and higher blood concentration of total cholesterol (P = 0.03;OR:1.12;95%CI:1.01,1.23). In univariate analysis, an increasing degree of ECAS was significantly correlated with a thinner RNFL.ConclusionsHigher prevalence and degree of ECAS were correlated with thinner RNFL and vice versa. Patients with abnormally thin RNFL without ocular disease may undergo carotid artery examination to detect asymptomatic carotid artery stenosis. Examination of the RNFL is useful for the diagnosis of cerebrovascular disease.

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Section: Methodsmentioning

confidence: 99%

Asymptomatic carotid artery stenosis and retinal nerve fiber layer thickness. A community-based, observational study

Wang

Zhou

et al. 2017

PLoS ONE

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“…Participants were regarded as having an occlusive disease if at least one of the studied arteries showed evidence of stenosis or occlusion. The neurologists were blinded to the blood pressure and other laboratory results of the participants [6].…”

Section: Methodsmentioning

confidence: 99%

“…A meta-analysis of 61 prospective studies reported that high blood pressure is strongly and directly related to vascular mortality in one million middle-aged and elderly people. This holds true in particular for cardiovascular and cerebrovascular diseases [1][2][3][4][5][6]. The Eighth Joint National Committee's 2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults reported the new blood pressure targets to treat people of different ages and with different diseases.…”

Section: Introductionmentioning

confidence: 99%

Different blood pressure indexes on intracranial arterial stenosis in Asymptomatic Polyvascular Abnormalities in Community study in China

Wang

Zhou

et al. 2015

Journal of Hypertension

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“…Hypertension is a major risk factor for cardiovascular and cerebrovascular diseases and mortality, [1][2][3][4] affecting approximately 1 billion individuals worldwide. 5 It is estimated that this number will escalate to more than 1.56 billion by the year 2025, 6 putting a tremendous burden on our health care systems.…”

Section: Introductionmentioning

confidence: 99%

“…42 Therefore, it would be of interest to see whether exercise still has some adjunctive effect in reducing BP in patients already treated with medication. Therefore, given the current limited and inconsistent results, we aimed in the present study (1) to investigate the acute effect of one single walking session at moderate intensity on PEH and (2) to test whether polymorphisms of the ACE gene contribute to the variation in PEH response in medicated patients.…”

Section: Introductionmentioning

confidence: 99%

ACE polymorphisms and the acute response of blood pressure to a walk in medicated hypertensive patients

Goessler

Cornelissen

Oliveira

et al. 2015

J Renin Angiotensin Aldosterone Syst

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Hypothesis/Introduction: Polymorphisms of the angiotensin converting enzyme (ACE) gene can interfere with exercise-induced acute blood pressure (BP) reduction. This cross-over study investigated the acute effect of a single walk on BP and tested whether polymorphisms of the ACE gene might explain the variation in BP responses. Materials and methods: Thirty-four healthy medicated individuals were randomized to one control and one walking session at 60-75% of heart rate reserve. Subjects left the laboratory wearing an ambulatory BP monitor until waking the next morning. Results: Overall, systolic BP was somewhat lower following the walking session (p=.06), which could be attributed to a consistently lower systolic BP for 5 h after exercise (p-interaction<.04) compared with control rest. Similarly, II/ID individuals had a lower systolic BP (p-interaction=.02) and diastolic BP (p-interaction<.01) for 5 h after walking compared with control rest. Among DD individuals, a single walk did not induce a reduction in BP (p-interaction>.05). Conclusions: Our results showed that postexercise hypotension can occur after a walk at moderate intensity in carriers of the I allele; we were not able to demonstrate this in DD individuals. Our results suggest that genetic variation in the ACE gene might affect the BP response to exercise, although more research is needed to confirm these findings.

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Arterial pre‐hypertension and hypertension in intracranial versus extracranial cerebrovascular stenosis

Abstract: The results suggest that arterial pre-hypertension in addition to hypertension is associated with a higher prevalence of asymptomatic ICAS, more in men.

Cited by 16 publications

References 41 publications

Asymptomatic carotid artery stenosis and retinal nerve fiber layer thickness. A community-based, observational study

Asymptomatic carotid artery stenosis and retinal nerve fiber layer thickness. A community-based, observational study

Different blood pressure indexes on intracranial arterial stenosis in Asymptomatic Polyvascular Abnormalities in Community study in China

ACE polymorphisms and the acute response of blood pressure to a walk in medicated hypertensive patients

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