ACE polymorphisms and the acute response of blood pressure to a walk in medicated hypertensive patients

Abstract

Hypothesis/Introduction: Polymorphisms of the angiotensin converting enzyme (ACE) gene can interfere with exercise-induced acute blood pressure (BP) reduction. This cross-over study investigated the acute effect of a single walk on BP and tested whether polymorphisms of the ACE gene might explain the variation in BP responses. Materials and methods: Thirty-four healthy medicated individuals were randomized to one control and one walking session at 60-75% of heart rate reserve. Subjects left the laboratory wearing an ambulatory BP monitor until waking the next morning. Results: Overall, systolic BP was somewhat lower following the walking session (p=.06), which could be attributed to a consistently lower systolic BP for 5 h after exercise (p-interaction<.04) compared with control rest. Similarly, II/ID individuals had a lower systolic BP (p-interaction=.02) and diastolic BP (p-interaction<.01) for 5 h after walking compared with control rest. Among DD individuals, a single walk did not induce a reduction in BP (p-interaction>.05). Conclusions: Our results showed that postexercise hypotension can occur after a walk at moderate intensity in carriers of the I allele; we were not able to demonstrate this in DD individuals. Our results suggest that genetic variation in the ACE gene might affect the BP response to exercise, although more research is needed to confirm these findings.

Angiotensin converting enzyme 2 polymorphisms and postexercise hypotension in hypertensive medicated individuals

“…polymorphism showed higher levels of serum ACE, whereas individuals II homozygous exhibited reduced levels of ACE compared to DD homozygotes (Rigat et al, 1990). In line with Santana et al, (2011), we recently found that hypertensive medicated carriers of the I-allele experienced PEH while DD homozygotes did not (Goessler et al, 2015). Following a single bout of exercise, Santana et al, (2011) observed PEH and increased nitric oxide levels only in carriers of the I allele.…”

“…In brief, volunteers were healthy men or women without known cardiovascular or pulmonary disease, age ≥40 years, non-smokers, clinically diagnosed with hypertension according to the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure (Chobanian et al, 2003) and being treated for at least 3 months with an angiotensin receptor blocker and/or ACE inhibitor. After screening and signing the informed consent, 34 individuals performed one control session and one exercise session (Goessler et al, 2015). The study was approved by the Research Ethics Committee of the State University of Londrina -Brazil (232/2013).…”

“…After the exercise and control sessions, participants were attached to an ambulatory BP monitoring (ABPM) device (Meditech, ABPM04, Budapest, Hungary) until waking the next morning (Goessler et al, 2015). Following pre-intervention measurements, each volunteer performed one of the two sessions in random order following a crossover design: a control session of 55 min of seated rest or one walking session including 45 min of walking at 60-75% of HR reserve and 5 min of warming up and cool down each.…”

“…A detailed description of the study design and methods has been published previously (Goessler et al, 2015). In brief, volunteers were healthy men or women without known cardiovascular or pulmonary disease, age ≥40 years, non-smokers, clinically diagnosed with hypertension according to the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure (Chobanian et al, 2003) and being treated for at least 3 months with an angiotensin receptor blocker and/or ACE inhibitor.…”

Prevalência de Hipertensão Arterial Sistêmica em Estudantes de Educação Física de uma Universidade Pública no Rio de Janeiro

“…Gus et al 16 compararam fatores de risco para doenças cardiovasculares no Rio Grande do Sul, em período temporal de 2002 a 2014, e puderam verificar que a prevalência de HAS aumentou a despeito de uma redução na prevalência de sedentarismo. Em verdade, contemporaneamente, alguns olhares da ciência já se propõem a observar pressupostos genéticos, quando da análise entre atividade física e saúde cardiovascular, pormenorizando dessa forma um discurso hegemônico mais grosseiro, que despreza parâmetros que podem estar associados à responsividade individual de cada sujeito ao estímulo do esforço físico 17,18 . É escassa a literatura no que diz respeito à prevalência de HAS em estudantes universitários, porém existem evidências de uma relação inversa entre anos de escolaridade e prevalência de HAS.…”