Different blood pressure indexes on intracranial arterial stenosis in Asymptomatic Polyvascular Abnormalities in Community study in China

Wang, Dandan; Wang, Chunxue; Zhou, Yong; Wang, Anxin; Gao, Xiang; Wu, Shouling; Zhao, Xingquan

doi:10.1097/hjh.0000000000000577

Cited by 9 publications

(8 citation statements)

References 26 publications

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“…Contradictory to a previous study on DBP and ICAS or cardiovascular disease, 14,26 we did not find any association between DBP and ICAS in this study. The negative findings in our study can be explained as follows.…”

Section: Association Between Dbp and Icascontrasting

confidence: 77%

“…27 The Systolic Blood Pressure Intervention Trial (SPRINT) subgroup analysis also suggested that lower DBP is not related to the first episode of stroke risk in the high-risk population. 28 Second, the DBP in this population was relatively lower than that in the previous study, 14…”

Section: Association Between Dbp and Icasmentioning

confidence: 52%

“…Basic characteristics of participants with and without ICAS abnormalities in a community-based study investigating different blood pressure indexes for predicting ICAS,14 and further demonstrated their association in different age subgroups, which has not been shown before. A Korean study indicated that stage 1 hypertension (SBP 130-139 mm Hg or DBP 80-89 mm Hg based on the 2017 ACC/AHA hypertension guidelines23 ) can be used as a predictor of ICAS by retrospectively analyzing the association between different blood pressure levels and ICAS in health checkup participants 24.…”

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confidence: 63%

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Association between blood pressure and intracranial artery stenosis in a Chinese population

Song

Zhao

Yang

et al. 2019

J of Clinical Hypertension

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The association between blood pressure and intracranial artery stenosis (ICAS) in different age groups has not been elucidated. Using data from the "China Hypertension Survey," we conducted a cross-sectional analysis of the association between blood pressure parameters and ICAS. In this study, participants older than 35 years were selected by stratified, multistage random sampling. Blood pressure was measured repeatedly at rest, and ICAS was assessed by transcranial doppler ultrasound. Binary logistic regression analysis was used to demonstrate the association between different blood pressure indicators and ICAS. Of the 3640 participants included (mean age 63 ± 13 years old, 57.8% female), systolic blood pressure (SBP) and pulse pressure (PP) were associated with ICAS in the general population; the multivariable adjusted odds ratio (OR) and corresponding 95% confidence interval (95% CI) of ICAS and multivessel stenosis were 1.32 (1.21, 1.45) and 1.29 (1.14, 1.46) per standard deviation (SD) increase in SBP and 1.44 (1.30, 1.59) and 1.52 (1.33, 1.74) for PP, respectively.Further analysis of this association in different age groups revealed inconsistent results between SBP and ICAS. Prehypertension (120 ≤ SBP < 140) could predict ICAS in the older group but not in the younger group, and the positive association between SBP and multivessel stenosis disappeared in the younger age group (P > .05 in all SBP subgroups). In conclusion, SBP and PP could not only identify ICAS in the middleaged and elderly population but could also provide some information about ICAS burden; however, these associations need to be interpreted differentially based on age subgroup.

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Section: Association Between Dbp and Icascontrasting

confidence: 77%

Section: Association Between Dbp and Icasmentioning

confidence: 52%

mentioning

confidence: 63%

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Association between blood pressure and intracranial artery stenosis in a Chinese population

Song

Zhao

Yang

et al. 2019

J of Clinical Hypertension

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“…IS patients, diagnosed according to the International Classification of Disease (9th revision, codes 430 to 438) on the basis of history, clinical symptoms, physical examination, and cranial computed tomography (CT) or magnetic resonance imaging (MRI) [ 31 ], were included in this study. CAS was diagnosed based on the level of the vessel stenosis according to the established criteria [ 30 , 32 ]. The age- and sex-matched controls were defined as no history of CAS and stroke and no family history of stroke.…”

Section: Methodsmentioning

confidence: 99%

Ischemic stroke is associated with the pro-inflammatory potential of N-glycosylated immunoglobulin G

Liu

Zhao

Wang

et al. 2018

J Neuroinflammation

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BackgroundGlycosylation significantly affects protein structure and function and thus participates in multiple physiologic and pathologic processes. Studies demonstrated that immunoglobulin G (IgG) N-glycosylation associates with the risk factors of ischemic stroke (IS), such as aging, obesity, dyslipidemia, type 2 diabetes, and hypertension.MethodsThe study aimed to investigate the association between IgG N-glycosylation and IS in a Chinese population. IgG glycome composition in patients with IS (n = 78) and cerebral arterial stenosis (CAS) (n = 75) and controls (n = 77) were analyzed by ultra-performance liquid chromatography.ResultsEleven initial glycans and 10 derived glycans in IgG glycome representing galactosylation, sialylation, and bisecting GlcNAc significantly differed between IS patients and CAS and healthy controls after controlling for gender, age, obesity, diabetes, hypertension, and dyslipidemia. Logistic regression models incorporating IgG glycan traits were able to distinguish IS from CAS (area under receiver–operator characteristic curves (AUC), 0.802; 95% confidence interval (CI), 0.732–0.872) and controls (AUC, 0.740; 95% CI, 0.661–0.819). The canonical correlation analysis indicated that initial N-glycan structures are significantly correlated with inflammation markers (r = 0.566, p < 0.001).ConclusionOur findings indicated that loss of galactose and sialic acid, as well as addition of bisecting GlcNAc, might involve in pro- or anti-inflammatory IgG functionality and further contribute to the pathogenesis of IS. IgG glycan profiles may be developed as clinical useful biomarkers for chronic disease in the future.Electronic supplementary materialThe online version of this article (10.1186/s12974-018-1161-1) contains supplementary material, which is available to authorized users.

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“…A number of studies indicate that hypertension, even pre-hypertension, is associated with a high prevalence of both asymptomatic and symptomatic ICAS. 54 , 55 , 56 , 57 , 58 , 59 , 60 However, relevant studies on blood pressure management in ICAS are limited. Although some trials, such as WASID and SAMMPRIS, suggest that blood pressure control is safe and beneficial in patients with ICAS, there is research indicating that over dose of hypotensive drugs increases the risk of stroke in patients with MCA stenosis.…”

Section: Treatmentmentioning

confidence: 99%

Intracranial artery stenosis: Current status of evaluation and treatment in China

Cai¹,

Peng²

2017

Chronic Diseases and Translational Medicine

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Intracranial artery stenosis (ICAS), a common cause of ischemic stroke, is a growing cause of concern in China. Recently, many epidemiological, etiological, pathophysiological, therapy, and diagnostic imaging studies have focused on ICAS, and guidelines and consensus on the diagnosis and treatment of ICAS have been published and updated by domestic experts. Such work is pivotal to our enhanced comprehension, diagnosis, and treatment of ICAS. In this review, we summarize the latest progress in the evaluation and treatment of ICAS in China.

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Different blood pressure indexes on intracranial arterial stenosis in Asymptomatic Polyvascular Abnormalities in Community study in China

Abstract: The current study results suggest that SBP, MAP, and PP are all associated with asymptomatic ICAS. PP may be the most sensitive index to predict ICAS.

Cited by 9 publications

References 26 publications

Association between blood pressure and intracranial artery stenosis in a Chinese population

Association between blood pressure and intracranial artery stenosis in a Chinese population

Ischemic stroke is associated with the pro-inflammatory potential of N-glycosylated immunoglobulin G

Intracranial artery stenosis: Current status of evaluation and treatment in China

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