Association between blood pressure and intracranial artery stenosis in a Chinese population

Abstract

The association between blood pressure and intracranial artery stenosis (ICAS) in different age groups has not been elucidated. Using data from the "China Hypertension Survey," we conducted a cross-sectional analysis of the association between blood pressure parameters and ICAS. In this study, participants older than 35 years were selected by stratified, multistage random sampling. Blood pressure was measured repeatedly at rest, and ICAS was assessed by transcranial doppler ultrasound. Binary logistic regression analysis was used to demonstrate the association between different blood pressure indicators and ICAS. Of the 3640 participants included (mean age 63 ± 13 years old, 57.8% female), systolic blood pressure (SBP) and pulse pressure (PP) were associated with ICAS in the general population; the multivariable adjusted odds ratio (OR) and corresponding 95% confidence interval (95% CI) of ICAS and multivessel stenosis were 1.32 (1.21, 1.45) and 1.29 (1.14, 1.46) per standard deviation (SD) increase in SBP and 1.44 (1.30, 1.59) and 1.52 (1.33, 1.74) for PP, respectively.Further analysis of this association in different age groups revealed inconsistent results between SBP and ICAS. Prehypertension (120 ≤ SBP < 140) could predict ICAS in the older group but not in the younger group, and the positive association between SBP and multivessel stenosis disappeared in the younger age group (P > .05 in all SBP subgroups). In conclusion, SBP and PP could not only identify ICAS in the middleaged and elderly population but could also provide some information about ICAS burden; however, these associations need to be interpreted differentially based on age subgroup.

Characteristics of intracranial atherosclerosis disease in stroke cases in Indonesia utilizing cerebral digital subtraction angiography

“…This relationship was particularly notable in the SBP ≥160 mmHg group. 10 Our findings corroborate and extend this earlier research, given that HHD is a consequence of chronic blood pressure elevation. Similarly, those with dyslipidaemia and coronary artery disease (CAD) in isolation from heart disturbances were also limited to 1.9%.…”

Percutaneous transluminal angioplasty and stenting vs aggressive medical management on stroke or intracranial atherosclerotic stenosis: a systematic review and meta-analysis

“…Furthermore, there was a significant increase in the burden of ICAS for every 10 mmHg increase in systolic and pulse pressure. Similarly, several studies have reported similar findings 40 , 41 . Besides, Wang et al 42 demonstrated that stress hyperglycemia is associated with ICAS and increases the risk of recurrent stroke.…”

Longitudinal real world correlation study of blood pressure and novel features of cerebral magnetic resonance angiography by artificial intelligence analysis on elderly cognitive impairment

“…In this study, there was no significant correlation between BP and the posterior circulatory artery stenosis scores by Spearman correlation analysis. A cross-sectional study recruited 3640 participants and found similar association between DBP and intracranial artery stenosis with us (Song et al, 2020). The DBP in this elderly population was relatively lower than that in the previous study and the predictive value of DBP decreased with the aging (Wang et al, 2015).…”

“…Abnormal BP is also one of the important causes of CI associated with a greater risk of cerebral artery stenosis (Maarten et al, 2020). Higher systolic blood pressure (SBP) and pulse pressure (PP) are associated with arterial stenosis in elderly individuals (Song et al, 2020). Some studies have reported that posterior cerebral arterial lesions are independent risk factors for dementia and MCI (Casado-Naranjo et al, 2016;Suri et al, 2018).…”