Arterial occlusion of pelvic bone tumors

Wallace, Sidney; Granmayeh, Masood; Desantos, Luis Alonso; Murray, John A.; Romsdahl, Marvin M.; Bracken, R. Bruce; Jonsson, Kjell

doi:10.1002/1097-0142(197901)43:1<322::aid-cncr2820430147>3.0.co;2-q

Cited by 76 publications

(37 citation statements)

References 18 publications

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“…According to this review, a satisfactory decrease of pain was observed in most cases, but duration of pain relief did not exceed 6 months in most cases in the two largest series [14,15], but a longer response was observed by Wallace and Soo in primary tumors [4,8].…”

Section: Discussionmentioning

confidence: 74%

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Selective intra-arterial chemoembolization of pelvic and spine bone metastases

et al. 2004

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The purpose of this study was to determine the effect of interventional palliative therapy by using chemoembolization on metastatic bone pain and tumor bulk in inoperable metastases where chemotherapy and radiotherapy had failed. Twenty-five patients (mean age: 59 years) underwent chemoembolization of symptomatic lytic lesions involving the spinal column (n=10), iliac bone and sacrum (n=15). The study design consisted of at least three procedures based on combined chemoembolization performed under analog-sedation. Therapeutic agents were carboplatin for selective chemotherapy and pirarubicin mixed with polyvinyl alcohol foam for chemoembolization. Fifteen of 18 (83%) patients had significant pain relief, as shown by the decrease of analgesic drug use. Mean clinical response duration was 12 months. Radiologically, ten patients were stable. A partial response was observed in four patients, while a complete response was seen in two others. Selective intra-arterial chemoembolization gives longer pain relief than embolization, compared to the literature data, probably because of partial response with local anti-cancer drugs.

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Section: Discussionmentioning

confidence: 74%

“…However, in some cases where large or predominant involvement of soft tissue or anatomical sites such as the sacrum are seen, this technique cannot be performed [1,2]. Some reports of palliative embolization showed temporary pain relief, but no effective tumoral response [3][4][5][6][7][8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Selective intra-arterial chemoembolization of pelvic and spine bone metastases

et al. 2004

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“…These report subjective improvement or relief of symptoms ranging from one to 9 months duration [16 Á19]. The majority of these patients were embolized with a combination of gelfoam and metallic coils [16,17,19]. Transcatheter embolization techniques have also successfully been applied to bony metastases from other hypervascular neoplasms such as thyroid [20] and hepatoma [21].…”

Section: Discussionmentioning

confidence: 99%

Selective palliative transcatheter embolization of bony metastases from renal cell carcinoma

et al. 2007

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“…The clinical data of all patients are shown comprehensively (please see the Appendix) 9,[21][22][23][24][25][26][27] . For the location of lesions, 41 (93.2%) patients' lesions were detected in the sacrum, while only 4 patients' lesions (1 had GCTB of sacrum and pelvis) were found in the ilium.…”

Section: Description Of Patients' Clinical Featuresmentioning

confidence: 99%

Selective Arterial Embolization for the Treatment of Sacral and Pelvic Giant Cell Tumor: A Systematic Review

Sun

et al. 2017

Orthopaedic Surgery

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Giant cell tumor of the bone (GCTB) is a locally aggressive tumor with a certain distant metastatic rate. For sacral GCT (SGCT) and pelvic GCT (PGCT), surgery has its limitations, especially for unresectable or recurrent tumors. Selective arterial embolization (SAE) is reported to be an option for treatment in several cases, but there are few systematic reviews on the effects of SAE on SGCT and/or PGCT. Medline and Embase databases were searched for eligible English articles. Inclusion and exclusion criteria were conducted before searching. All the clinical factors were measured by SPSS software, with P-values ≤0.05 considered statistically significant. A total of 9 articles were retrieved, including 44 patients receiving SAE ranging from 1 to 10 times. During the mean follow-up period of 85.8 months, the radiographic response rate was 81.8%, with a local control and overall survival rate of 75% and 81.8%, respectively. No bowel, bladder, or sexual dysfunction was observed. Three patients developed distant metastases and finally died. Patients with primary tumors tended to have better prognosis than those with recurrence (P = 0.039). The favorable outcomes of SAE suggest that it may be an alternative treatment for SGCT and PGCT patients for whom surgery is not appropriate.Key words: Local control; Overall survival; Pelvis; Sacral giant cell tumor; Selective arterial embolization Introduction G iant cell tumor of bone (GCTB) is defined as a potential locally aggressive tumor with a distant metastatic rate of approximately 6.6% [1][2][3][4][5][6] . It occurs most in the second to fourth decades of young adults, but also can be found in patients at any other period. Morbidities between men and women are almost equal. Epiphysis and metaphysis of long bones are the most prevalent sites among the GCT occurrence sites, especially at the distal femur and proximal tibia. Sacral giant cell tumor (SGCT) is the third most common GCTB. SGCT accounts for 2%-8% of all GCTB cases, while pelvic giant cell tumors (PGCT) are less frequent [7][8][9][10][11] . Pain is the most common complaint due to the osteolytic destruction. Other clinical manifestations include pathological fracture, losing control of bladder and bowel, as well as sexual dysfunction. Pathological fracture is generally considered as a potential predictor of higher local recurrence and distant metastases rate. GCTB are usually a solid brown mass. Histologically, they contain substantial multinucleated osteoclastlike giant cells and mononuclear stromal cells. According to their radiological appearance, GCTB are classified by Campanacci et al. 5 into three grades: Stage I, latent; Stage II, active; and Stage III, aggressive.Although surgery remains the treatment of choice for local SGCT, it is limited by a high recurrence rate and heavy surgical bleeding due to the complex anatomic structures, regardless of wide excision or intralesional curretage 8,12 . In addition, neurological dysfunction at the expense of incontinence and sexual dysfunction could lead to psychol...

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Arterial occlusion of pelvic bone tumors

Cited by 76 publications

References 18 publications

Selective intra-arterial chemoembolization of pelvic and spine bone metastases

Selective intra-arterial chemoembolization of pelvic and spine bone metastases

Selective palliative transcatheter embolization of bony metastases from renal cell carcinoma

Selective Arterial Embolization for the Treatment of Sacral and Pelvic Giant Cell Tumor: A Systematic Review

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