Release 2.5 of the International Comprehensive Ocean-Atmosphere Data Set (ICOADS) is a major update (covering 1662-2007) of the world's most extensive surface marine meteorological data collection. Building on extensive national and international partnerships, many new and improved contributing datasets have been processed into a uniform format and combined with the previous Release 2.4. The new data range from early non-instrumental ship observations to measurements initiated in the twentieth century from buoys and other automated platform types. Improvements to existing data include replacing preliminary Global Telecommunication System (GTS) receipts with more reliable, delayed mode reports for post-1997 data, and in the processing and quality control (QC) of humidity observations. Over the entire period of record, spatial and temporal coverage has been enriched and data and metadata quality has been improved. Along with the observations, now updated monthly in near real time, Release 2.5 includes quality-controlled monthly summary products for 2°latitude × 2°longitude (since 1800) and 1°× 1°boxes (since 1960), together with multiple options for access to the data and products. The measured and estimated data in Release 2.5 are subject to many technical changes, multiple archive sources, and historical events throughout the more than three-century record. Some of these data characteristics are highlighted, including known unresolved errors and inhomogeneities, which may impact climate and other research applications. Anticipated future directions for ICOADS aim to continue adding scientific value to the observations, products, and metadata, as well as strengthen the cooperative enterprise through expanded linkages to international initiatives and organisations.

Background:Patients with pancreatic cancer have a poor prognosis apart from the few suitable for surgery. Photodynamic therapy (PDT) produces localised tissue necrosis but previous studies using the photosensitiser meso-tetrahydroxyphenylchlorin (mTHPC) caused prolonged skin photosensitivity. This study assessed a shorter acting photosensitiser, verteporfin.Methods:Fifteen inoperable patients with locally advanced cancers were sensitised with 0.4 mg kg−1 verteporfin. After 60–90 min, laser light (690 nm) was delivered via single (13 patients) or multiple (2 patients) fibres positioned percutaneously under computed tomography (CT) guidance, the light dose escalating (initially 5 J, doubling after each three patients) until 12 mm of necrosis was achieved consistently.Results:In all, 12 mm lesions were seen consistently at 40 J, but with considerable variation in necrosis volume (mean volume 3.5 cm3 at 40 J). Minor, self-limiting extrapancreatic effects were seen in multifibre patients. No adverse interactions were seen in patients given chemotherapy or radiotherapy before or after PDT. After PDT, one patient underwent an R0 Whipple's pancreaticoduodenectomy.Conclusions:Verteporfin PDT-induced tumour necrosis in locally advanced pancreatic cancer is feasible and safe. It can be delivered with a much shorter drug light interval and with less photosensitivity than with older compounds.

ABSTRACT:We highlight improvements to the International Comprehensive Ocean-Atmosphere Data Set (ICOADS) in the latest Release 3.0 (R3.0; covering . ICOADS is the most widely used freely available collection of surface marine observations, providing data for the construction of gridded analyses of sea surface temperature, estimates of air-sea interaction and other meteorological variables. ICOADS observations are assimilated into all major atmospheric, oceanic and coupled reanalyses, further widening its impact. R3.0 therefore includes changes designed to enable effective exchange of information describing data quality between ICOADS, reanalysis centres, data set developers, scientists and the public. These user-driven innovations include the assignment of a unique identifier (UID) to each marine report -to enable tracing of observations, linking with reports and improved data sharing. Other revisions and extensions of the ICOADS' International Maritime Meteorological Archive common data format incorporate new near-surface oceanographic data elements and cloud parameters. Many new input data sources have been assembled, and updates and improvements to existing data sources, or removal of erroneous data, made. Coupled with enhanced 'preliminary' monthly data and product extensions past 2014, R3.0 provides improved support of climate assessment and monitoring, reanalyses and near-real-time applications.

No abstract

A new method of analyzing weather reports from merchant ships leads to improved in situ air-sea heat flux datasets and information about the uncertainty of the flux estimates.T he ocean surface heat budget comprises radiative and turbulent components: the radiative components are solar shortwave and thermal longwave, both of which are strongly affected by cloud; the turbulent heat flux components are the direct transfer of sensible heat and the evaporative transfer of latent heat. Although direct measurements of the turbulent fluxes are possible, they remain a research activity due to the high cost of the measurements. Measurement of the radiative components is easier but still challenging on long-term deployments. As a result, global marine flux datasets are typically constructed using bulk estimates of the mean meteorological parameters and flux parameterizations, known as "bulk formulas."Various sources exist for the bulk meteorological parameters, ranging from model output and satellite observations to •