Aromatic-turmerone ameliorates imiquimod-induced psoriasis-like inflammation of BALB/c mice

Li, Yongliang; Du, Zhiyun; Li, Penghui; Yan, Longjia; Zhou, Wei; Tang, Yadong; Liu, Guangrong; Fang, Yanxiong; Zhang, Kun; Dong, Chang‐Zhi; Chen, Hui-Xiong

doi:10.1016/j.intimp.2018.09.015

Cited by 45 publications

(25 citation statements)

References 32 publications

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“…The preparation of skin tissue lysates of mice and the experimental procedure of Western blot were performed as described in previous studies. 20 A BCA kit was used for the quantification of protein contents in lysates. Antibodies against FLG and AQP3 were purchased from ABcam.…”

Section: Western Blot Analysismentioning

confidence: 99%

Elaeagnus L gum polysaccharides alleviate the impairment of barrier function in the dry skin model mice

Wang

Tai

Zhang

et al. 2020

J of Cosmetic Dermatology

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Background Dry skin is a common skin condition caused by reduction of water‐holding capacity, which is regulated by skin barrier function. Dry skin can also be a symptom that indicates a more serious diagnosis. There are a number of moisturizers on the market, which play an important role in dermatologic and cosmetic therapies. However, the demand for these products with good and therapeutic efficiency is still growing. Aims It remains necessary to investigate the effects of Elaeagnus L gum polysaccharides (EAP), which are prepared from gum of Elaeagnus angustifolia L. on the epidermal permeability barrier function and their possible underlying mechanisms. Patients/Methods EAP were purified, analyzed, and tested on human keratinocyte cell line (HaCaT) and then on the skin in vivo to evaluate their antiinflammatory activities and their impacts on impaired skin barrier function. Results Histological analyses revealed that topical administration with EAP effectively attenuated dryness‐like skin condition, including less percutaneous water loss rate, less infiltrate inflammation cells, and less epidermal thickening. Moreover, EAP inhibited the production of various inflammatory mediators and increased AQP‐3, FLG, and LOR expression. Conclusion Our results indicated that EAP enhances epidermal permeability barrier function, and they can be used as a promising adjuvant agent in skin care cosmetics and in treating some skin disorders characterized by cutaneous inflammation and abnormal barrier function.

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Section: Western Blot Analysismentioning

confidence: 99%

Elaeagnus L gum polysaccharides alleviate the impairment of barrier function in the dry skin model mice

Wang

Tai

Zhang

et al. 2020

J of Cosmetic Dermatology

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“…The cellular background for the inhibition of inflammation and that of keratinocyte abnormal proliferation resides on nuclear factor-κB (NF-κB) suppression, TNF-α, IL-1β and IL-6 downregulation and inactivation of JNK, p38 MAPK and STAT-3 pathways. It modulates dendritic cells and also reduces the levels of IL-2 and interferon-γ (27,31).…”

Section: Resultsmentioning

confidence: 99%

“…Materials and methods used in the studies had common grounds: many used BALB/c mice, had several days of imiquimod 5% applied on the hairless back skin and ear followed by topical curcumin ointments or gel applications. The evolution and involution of psoriatic lesions were evaluated by the PASI Score, Psoriasis Area and Severity Index which follows the erythema, scales and thickness of the affected skin (26,(31)(32)(33)(34).…”

Section: Resultsmentioning

confidence: 99%

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Influence of phytochemicals in induced psoriasis (Review)

Niculeț

Radaschin

Năstase³

et al. 2020

Exp Ther Med

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“…The IL-23/IL-17 axis has been reported to be a critical regulator for psoriasis and psoriatic arthritis. Studies have reported that IMQ-induced psoriasis-like skin elicited either protein or mRNA expression of IL-17, IL-23, IL-1β, IL-6, TNF-α, and interferon-γ(INF-γ) in mouse skin [3,[35][36][37] and successful anti-psoriasis treatment inhibited the above-mentioned cytokine expression [35][36][37]. Our study demonstrated a significant increase in IL-23/IL-17 cytokine protein expression after six consecutive days of IMQ application.…”

Section: Discussionmentioning

confidence: 99%

Salvianolic Acid B in Microemulsion Formulation Provided Sufficient Hydration for Dry Skin and Ameliorated the Severity of Imiquimod-induced Psoriasis-like Dermatitis in Mice

et al. 2020

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Psoriasis is a chronic inflammatory skin disorder with a pathogenesis involving the interleukin-23/interleukin-17 axis. Salvianolic acid B exerts several pharmacological effects, such as antioxidation, anti-inflammation, and antitumor effects. The anti-psoriatic effects of salvianolic acid B have not been reported. In this study, we aimed to determine the optimum vehicle for salvianolic acid B, investigate its therapeutic effect on psoriatic-like skin conditions, and explore its underlying mechanisms of action. BALB/c mice were administered topical imiquimod to induce psoriasis-like skin and were then randomly assigned to control, vehicle control, salvianolic acid B in vehicles, and 0.25% desoximetasone ointment treatment groups. Barrier function, cytokine expression, histology assessment, and disease severity were evaluated. The results showed that salvianolic acid B-containing microemulsion alleviated disease severity, reduced acanthosis, and inhibited interleukin-23/interleukin-17 (IL-23/IL-17) cytokines, epidermal proliferation, and increased skin hydration. Our study suggests that salvianolic acid B represents a possible new therapeutic drug for the treatment of psoriasis. In addition, such formulation could obtain high therapeutic efficacy in addition to providing sufficient hydration for dry skin.

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Aromatic-turmerone ameliorates imiquimod-induced psoriasis-like inflammation of BALB/c mice

Cited by 45 publications

References 32 publications

Elaeagnus L gum polysaccharides alleviate the impairment of barrier function in the dry skin model mice

Elaeagnus L gum polysaccharides alleviate the impairment of barrier function in the dry skin model mice

Influence of phytochemicals in induced psoriasis (Review)

Salvianolic Acid B in Microemulsion Formulation Provided Sufficient Hydration for Dry Skin and Ameliorated the Severity of Imiquimod-induced Psoriasis-like Dermatitis in Mice

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