Influence of phytochemicals in induced psoriasis (Review)

“…The current therapeutic strategy can manage the disease but does not ensure the complete cure. 24 So far no one model can meet all of the research needs for psoriasis. Therefore, the choice of model system will depend on the questions being addressed.…”

Section: Discussionmentioning

confidence: 99%

Differential Psoriatic Effect of Imiquimod on Balb/c and Swiss Mice

Salwa

Badanthadka

D’Souza³

2021

Journal of Health and Allied Sciences NU

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Introduction The influence of animal strain on psoriasis model development by imiquimod (IMQ) has been studied in Balb/c and Swiss mice. Materials and Methods Female mice of either strain were challenged with 5% IMQ (62.5 mg on back skin, 10 mg on right ear). They were observed for the severity of the disease using Psoriasis area severity index (PASI), splenomegaly, and histopathological alterations. To validate the model, well-established antipsoriatic drug clobetasol (0.05%, 120 mg on the back skin, 10 mg on the right ear) was used. Additionally, to study the strain-dependent response to IMQ associated with oxidative stress, various antioxidant factors like superoxide dismutase (SOD), catalase (CT), and glutathione (GSH) were measured. Antioxidant natural product curcumin (1%, 150 mg on back skin, 12.5 mg on right ear) was used to evaluate the alleviation of oxidative stress on distinct mice strain. Results PASI score, body weight, and histopathology indicated the development of disease in both the strains, severity, and stability of which was dependent on the particular strain. Splenomegaly suggested the systemic effect, which was comparable in both the stains. IMQ and its involvement in redox status were confirmed by an alteration in the activity of SOD, CT, and levels of GSH. Conclusion This study demonstrated that, in the IMQ-induced psoriasis model, the genetic background has some impact on the disease severity, stability, and redox imbalance.

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“…In the continuous fight against such Gram-negative pathogens, interleukin-6 (IL-6) seems to have an inhibiting effect, expressing antibacterial properties, an intriguing subject which summons further research. [14][15][16][17][18] The development of new antibiotics is far from keeping the pace with MDR progression rate. Thus, preserving the available antibiotics' actions through the rational use of antibiotics is a measure adopted as an objective within the programs of antibiotic stewardship and it is mandatory concerning the quality standards of hospital activity, in accordance with Global Action Plan on Antimicrobial Resistance developed by the World Health Organization (WHO) and also with the regulations of the European Antimicrobial Resistance Surveillance Network (EARS-Net), which has Romania as a member.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Antibiotic Resistance of ESKAPE Pathogens Over Five Years in an Infectious Diseases Hospital from South-East of Romania

Arbune¹,

Gurău²,

Niculeț³

et al. 2021

IDR

Self Cite

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Purpose This study aimed at identifying the main antimicrobial resistance of ESKAPE ( Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Escherichia coli ) pathogens in a Romanian infectious diseases hospital. This antimicrobial resistance is a global threat, having high rates of multidrug resistance and limited treatment options. Patients and Methods This retrospective study (2016–2020) assessed the antimicrobial resistance of ESKAPE pathogens isolated from the patient’s biological samples. The microbiological diagnosis was performed by classical culture methods. The antimicrobial susceptibility analysis used the Kirby–Bauer disk-diffusion method and the method of minimum inhibiting concentration with the automated Vitek, according to the CLSI (Clinical and Laboratory Standards Institute) standards. Results Included in this study were 4293 bacterial isolates: 67% Gram-negative bacilli, 31% Gram-positive cocci and 2% other morphotinctorial bacteria. ESKAPE pathogens were found in 97% of the bacterial isolates strains; E. coli (38.26%) and Staphylococcus aureus (26%) were the most prevalent. Most bacterial strains were isolated from urine cultures (45.6%), skin and soft tissue secretions/collections (35.9%) and also blood cultures (4.2%). Increased antimicrobial resistance was observed for methicillin-resistant Staphylococcus aureus (MRSA)s, extended spectrum beta-lactamase producing (ESBL) Enterobacterales, carbapenem-resistant (CR) Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae . No vancomycin resistance was found for Enterococcus faecium . The highest prevalence rates of multidrug resistance were found in methicillin-resistant Staphylococcus aureus (86.6%), Acinetobacter baumannii (36.8%), Pseudomonas aeruginosa (29.1%) and Klebsiella pneumoniae (24.4%). Conclusion ESKAPE pathogens are frequently isolated in the infectious diseases hospital, with main antimicrobial resistance: ESBL, MRSA and CR. The local antimicrobial resistance pattern is essential in updating the local protocols and for appropriately prescribing antibiotics. Streamlining microbiological diagnosis and aligning with the European standards for antimicrobial susceptibility testing are necessary steps in harmonizing the regional network for good antimicrobial resistance control practices.

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Influence of phytochemicals in induced psoriasis (Review)

Cited by 16 publications

References 40 publications

Glucocorticoid-Induced Skin Atrophy: The Old and the New

Glucocorticoid-Induced Skin Atrophy: The Old and the New

Differential Psoriatic Effect of Imiquimod on Balb/c and Swiss Mice

Prevalence of Antibiotic Resistance of ESKAPE Pathogens Over Five Years in an Infectious Diseases Hospital from South-East of Romania

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