Glucocorticoid-Induced Skin Atrophy: The Old and the New

Niculeț, Elena; Bobeică, Carmen; Tatu, Alin Laurențiu

doi:10.2147/ccid.s224211

Cited by 45 publications

(22 citation statements)

References 60 publications

(162 reference statements)

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“…In the continuous fight against such Gram-negative pathogens, interleukin-6 (IL-6) seems to have an inhibiting effect, expressing antibacterial properties, an intriguing subject which summons further research. [14][15][16][17][18] The development of new antibiotics is far from keeping the pace with MDR progression rate. Thus, preserving the available antibiotics' actions through the rational use of antibiotics is a measure adopted as an objective within the programs of antibiotic stewardship and it is mandatory concerning the quality standards of hospital activity, in accordance with Global Action Plan on Antimicrobial Resistance developed by the World Health Organization (WHO) and also with the regulations of the European Antimicrobial Resistance Surveillance Network (EARS-Net), which has Romania as a member.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Antibiotic Resistance of ESKAPE Pathogens Over Five Years in an Infectious Diseases Hospital from South-East of Romania

Arbune¹,

Gurău²,

Niculeț³

et al. 2021

IDR

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Purpose This study aimed at identifying the main antimicrobial resistance of ESKAPE ( Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Escherichia coli ) pathogens in a Romanian infectious diseases hospital. This antimicrobial resistance is a global threat, having high rates of multidrug resistance and limited treatment options. Patients and Methods This retrospective study (2016–2020) assessed the antimicrobial resistance of ESKAPE pathogens isolated from the patient’s biological samples. The microbiological diagnosis was performed by classical culture methods. The antimicrobial susceptibility analysis used the Kirby–Bauer disk-diffusion method and the method of minimum inhibiting concentration with the automated Vitek, according to the CLSI (Clinical and Laboratory Standards Institute) standards. Results Included in this study were 4293 bacterial isolates: 67% Gram-negative bacilli, 31% Gram-positive cocci and 2% other morphotinctorial bacteria. ESKAPE pathogens were found in 97% of the bacterial isolates strains; E. coli (38.26%) and Staphylococcus aureus (26%) were the most prevalent. Most bacterial strains were isolated from urine cultures (45.6%), skin and soft tissue secretions/collections (35.9%) and also blood cultures (4.2%). Increased antimicrobial resistance was observed for methicillin-resistant Staphylococcus aureus (MRSA)s, extended spectrum beta-lactamase producing (ESBL) Enterobacterales, carbapenem-resistant (CR) Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae . No vancomycin resistance was found for Enterococcus faecium . The highest prevalence rates of multidrug resistance were found in methicillin-resistant Staphylococcus aureus (86.6%), Acinetobacter baumannii (36.8%), Pseudomonas aeruginosa (29.1%) and Klebsiella pneumoniae (24.4%). Conclusion ESKAPE pathogens are frequently isolated in the infectious diseases hospital, with main antimicrobial resistance: ESBL, MRSA and CR. The local antimicrobial resistance pattern is essential in updating the local protocols and for appropriately prescribing antibiotics. Streamlining microbiological diagnosis and aligning with the European standards for antimicrobial susceptibility testing are necessary steps in harmonizing the regional network for good antimicrobial resistance control practices.

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Section: Introductionmentioning

confidence: 99%

Prevalence of Antibiotic Resistance of ESKAPE Pathogens Over Five Years in an Infectious Diseases Hospital from South-East of Romania

Arbune¹,

Gurău²,

Niculeț³

et al. 2021

IDR

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“…Steroid cream should be applied for no more than 7 days, and a long-term use should be avoided because of potential thinning of perianal and anal mucosa and increasing risk of injury [122,123]. There are no scientific data evaluating either NSAIDS, cortisone, and its derivates or injection of local anesthetics for the treatment of complicated hemorrhoids.…”

Section: C -In Patients With Complicated Hemorrhoids What Is the Role Of Endoscopy?mentioning

confidence: 99%

Anorectal emergencies: WSES-AAST guidelines

et al. 2021

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Anorectal emergencies comprise a wide variety of diseases that share common symptoms, i.e., anorectal pain or bleeding and might require immediate management. While most of the underlying conditions do not need inpatient management, some of them could be life-threatening and need prompt recognition and treatment. It is well known that an incorrect diagnosis is frequent for anorectal diseases and that a delayed diagnosis is related to an impaired outcome. This paper aims to improve the knowledge and the awareness on this specific topic and to provide a useful tool for every physician dealing with anorectal emergencies.The present guidelines have been developed according to the GRADE methodology. To create these guidelines, a panel of experts was designed and charged by the boards of the World Society of Emergency Surgery (WSES) and American Association for the Surgery of Trauma (AAST) to perform a systematic review of the available literature and to provide evidence-based statements with immediate practical application. All the statements were presented and discussed during the WSES-AAST-WJES Consensus Conference on Anorectal Emergencies, and for each statement, a consensus among the WSES-AAST panel of experts was reached. We structured our work into seven main topics to cover the entire management of patients with anorectal emergencies and to provide an up-to-date, easy-to-use tool that can help physicians and surgeons during the decision-making process.

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“…In addition to reduced keratinocyte proliferation [ 9 ], fibroblast proliferation is suppressed, and there is decreased production of mucopolysaccharides (e.g., hyaluronic acid), elastin, matrix metalloproteases, and collagen 1 and 3. Mast cell numbers are reduced, dermal support is lost, and skin becomes thinned and loses elasticity [ 49 ].…”

Section: Taz and Hp: Mechanisms Of Action In Psoriasismentioning

confidence: 99%

Fixed-Combination Halobetasol Propionate and Tazarotene in the Treatment of Psoriasis: Narrative Review of Mechanisms of Action and Therapeutic Benefits

Lebwohl

Tanghetti

Gold

et al. 2021

Dermatol Ther (Heidelb)

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Psoriasis is a lifelong disease associated with cycles of remission and relapse. Topical treatments are the front line of psoriasis therapy for most patients and have antiproliferative, antiinflammatory, and immunosuppressive mechanisms of action. Novel fixed-dose combinations of topical therapeutic agents are becoming increasingly available, leveraging multiple mechanisms of action to improve safety and efficacy with formulations that are easier to use and may allow for the use of lower doses of active ingredients. A fixed-combination lotion containing the potent-to-superpotent corticosteroid halobetasol propionate (HP) and the retinoid tazarotene (HP 0.01%/TAZ 0.045%) was recently developed using polymeric emulsion technology. This new formulation technology allows for more uniform and efficient delivery of the active ingredients at lower doses than conventional monotherapy formulations of either ingredient while providing enhanced hydration and moisturization. This review provides an up-to-date overview of the therapeutic mechanisms of action of HP and TAZ, the rationale behind the development of HP 0.01%/ TAZ 0.045% lotion, and clinical trials data on the efficacy, safety and tolerability, and maintenance of therapeutic effect with HP 0.01%/ TAZ 0.045% lotion in the treatment of moderate-to-severe plaque psoriasis.

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Glucocorticoid-Induced Skin Atrophy: The Old and the New

Cited by 45 publications

References 60 publications

Prevalence of Antibiotic Resistance of ESKAPE Pathogens Over Five Years in an Infectious Diseases Hospital from South-East of Romania

Prevalence of Antibiotic Resistance of ESKAPE Pathogens Over Five Years in an Infectious Diseases Hospital from South-East of Romania

Anorectal emergencies: WSES-AAST guidelines

Fixed-Combination Halobetasol Propionate and Tazarotene in the Treatment of Psoriasis: Narrative Review of Mechanisms of Action and Therapeutic Benefits

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