Elaeagnus L gum polysaccharides alleviate the impairment of barrier function in the dry skin model mice

Abstract

Background Dry skin is a common skin condition caused by reduction of water‐holding capacity, which is regulated by skin barrier function. Dry skin can also be a symptom that indicates a more serious diagnosis. There are a number of moisturizers on the market, which play an important role in dermatologic and cosmetic therapies. However, the demand for these products with good and therapeutic efficiency is still growing. Aims It remains necessary to investigate the effects of Elaeagnus L gum polysaccharides (EAP), which are prepared from gum of Elaeagnus angustifolia L. on the epidermal permeability barrier function and their possible underlying mechanisms. Patients/Methods EAP were purified, analyzed, and tested on human keratinocyte cell line (HaCaT) and then on the skin in vivo to evaluate their antiinflammatory activities and their impacts on impaired skin barrier function. Results Histological analyses revealed that topical administration with EAP effectively attenuated dryness‐like skin condition, including less percutaneous water loss rate, less infiltrate inflammation cells, and less epidermal thickening. Moreover, EAP inhibited the production of various inflammatory mediators and increased AQP‐3, FLG, and LOR expression. Conclusion Our results indicated that EAP enhances epidermal permeability barrier function, and they can be used as a promising adjuvant agent in skin care cosmetics and in treating some skin disorders characterized by cutaneous inflammation and abnormal barrier function.

Oryza Ceramide®, a rice-derived extract consisting of glucosylceramides and β-sitosterol glucoside, improves facial skin dehydration in Japanese subjects

“…The loss of epidermal moisture causes dry, itchy, sensitive skin [35]. Epidermal moisture levels are lower in patients with dry skin than in normal subjects [36].…”

Expression analysis of genes important for maintaining skin function in a senescence‐accelerated mouse prone model

“…Normally, in the skin, water is transported from the blood vessel side to the stratum corneum side, and moisture is retained in the stratum corneum. However, when the stratum corneum barrier function breaks down and the amount of water loss increases, the dermal water content decreases, and the skin becomes dry 31,32 . From the results of this study, it was considered unlikely that skin dryness in the SAMP mice was caused by a decrease in barrier function.…”

“…However, when the stratum corneum barrier function breaks down and the amount of water loss increases, the dermal water content decreases, and the skin becomes dry. 31,32 From the results of this study, it was considered unlikely that skin dryness in the SAMP mice was caused by a decrease in barrier function.…”

Cux1+ proliferative basal cells promote epidermal hyperplasia in chronic dry skin disease identified by single-cell RNA transcriptomics

“…The acetone/ether/water (AEW) treatment induces increased transepidermal water loss, reduced stratum corneum hydration, hyperkeratosis, and elevated scratch behavior, which is a well-established chronic dry skin model and accurately mimics the clinical manifestations in humans [ 3 ]. Recently, decreased expression of filaggrin, loricrin, and aquaporin 3 has been suggested to participate in the impaired barrier and moisturizing function of the skin in an AEW model [ 4 ]. However, a systematic and comprehensive study of the pathogenic mechanisms of the AEW model is still lacking.…”